Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Christine Sturchler-Pierrat"'
Publikováno v:
Annals of the New York Academy of Sciences. 920:134-139
APP23 transgenic mice overexpress human APP with the Swedish double mutation. The mice start to develop amyloid plaque pathology at about six months of age, followed somewhat later by vascular amyloid deposits. Plaques are mostly of the compact type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4433bf649e0c75b2205109400861d52
https://doi.org/10.1111/j.1749-6632.2000.tb06915.x
https://doi.org/10.1111/j.1749-6632.2000.tb06915.x
Autor:
Stephen D. Schmidt, Dorothee Abramowski, Marion L.C. Maat-Schieman, Simone Danner, Paul M. Mathews, Patrick Burgermeister, Esther Kohler, David T. Winkler, Mathias Jucker, Sjoerd G. van Duinen, Matthias Staufenbiel, Kurt Bürki, Christine Sturchler-Pierrat, Michelle Pfeifer, Martin C. Herzig
Publikováno v:
Nature Neuroscience. 7:954-960
The E693Q mutation in the amyloid beta precursor protein (APP) leads to cerebral amyloid angiopathy (CAA), with recurrent cerebral hemorrhagic strokes and dementia. In contrast to Alzheimer disease (AD), the brains of those affected by hereditary cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89d27edd3d2af5bd665d7aa827e2a29d
https://doi.org/10.1038/nn1302
https://doi.org/10.1038/nn1302
Autor:
Stephanie Schäfer, Thomas Kamer, Thomas A. Bayer, Dorothee Abramowski, Matthias Staufenbiel, Gerd Multhaup, Christine Sturchler-Pierrat, Katrin Schüssel, Andreas Simons, Ralf Tepest, Oliver Eikenberg, André Kemmling, Anne Eckert
Publikováno v:
Proceedings of the National Academy of Sciences. 100:14187-14192
The Cu-binding β-amyloid precursor protein (APP), and the amyloid Aβ peptide have been proposed to play a role in physiological metal regulation. There is accumulating evidence of an unbalanced Cu homeostasis with a causative or diagnostic link to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48a297b0d2ece64c76bcacd46cc40adc
https://doi.org/10.1073/pnas.2332818100
https://doi.org/10.1073/pnas.2332818100
Autor:
Luca Bondolfi, Michelle Pfeifer, Peter H. Kelly, Martina Stalder, Sonia Boncristiano, Mathias Jucker, Michael E. Calhoun, Matthias Staufenbiel, Amie L. Phinney, Bernd Sommer, Dorothee Abramowski, Albert Enz, Christine Sturchler-Pierrat
Publikováno v:
The Journal of Neuroscience. 22:3234-3243
Alzheimer's Disease (AD) is a neurodegenerative disorder that is characterized by extracellular deposits of amyloid-beta peptide (Abeta) and a severe depletion of the cholinergic system, although the relationship between these two events is poorly un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a69a891d213f9023d905fa6fab2083
https://doi.org/10.1523/jneurosci.22-08-03234.2002
https://doi.org/10.1523/jneurosci.22-08-03234.2002
Autor:
Yu Min Kuo, Walter M. Kalback, Tyler A. Kokjohn, Dean C. Luehrs, Matthias Staufenbiel, Christine Sturchler-Pierrat, Roy O. Weller, Dorothee Abramowski, Tatiana A. Vishnivetskaya, Lucia I. Sue, Alex E. Roher, Sarah Scott, Kathryn J. Layne, Thomas G. Beach
Publikováno v:
Molecular Medicine. 7:609-618
High levels of Aβ in the cerebral cortex distinguish demented Alzheimer’s disease (AD) from nondemented elderly individuals, suggesting that decreased amyloid-beta (Aβ) peptide clearance from the brain is a key precipitating factor in AD. The lev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::185dbaa8af6df53b14020ad099e4f9c5
https://doi.org/10.1007/bf03401867
https://doi.org/10.1007/bf03401867
Autor:
Henrike Hartmann, Hans Clevers, Viet Minh Do, Bernd Sommer, Matthias Staufenbiel, Christine Sturchler-Pierrat, Paul Saftig, Zhuohua Zhang, Xi He, M. Van De Wetering, B. De Strooper, Dorothee Abramowski, Bruce A. Yankner
Publikováno v:
Nature. 395:698-702
Mutations of the presenilin-1 gene are a major cause of familial early-onset Alzheimer's disease. Presenilin-1 can associate with members of the catenin family of signalling proteins, but the significance of this association is unknown. Here we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adc611d29df9169e7110d1f61d32562
https://doi.org/10.1038/27208
https://doi.org/10.1038/27208
Autor:
Matthias Staufenbiel, Christine Sturchler-Pierrat, Birgit Ledermann, Dorothee Abramowski, Claudia Mistl, Michael E. Calhoun, Paolo Paganetti, Kurt Bürki, Karl-Heinz Wiederhold, Caroline Waridel, Mathias Jucker, Mairead Duke, Sabin Rothacher, Bernd Sommer, Alphonse Probst, Peter Frey
Publikováno v:
Proceedings of the National Academy of Sciences. 94:13287-13292
Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer disease (AD) by affecting the formation of the amyloid β (Aβ) peptide, the major constituent of AD plaques. We expressed human APP 751 containing these mutat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786858b5a6db5710cfe8f7417e131aba
https://doi.org/10.1073/pnas.94.24.13287
https://doi.org/10.1073/pnas.94.24.13287
Autor:
Takaharu Mizutani, Alain Krol, Philippe Carbon, Christine Sturchler-Pierrat, Nadia Hubert, Tsuyoshi Totsuka
Publikováno v:
Journal of Biological Chemistry. 270:18570-18574
Selenocysteine synthesis is achieved on a specific tRNA, tRNA(Sec), which is first charged with serine to yield seryl-tRNA(Sec). Eukaryotic tRNA(Sec) exhibits an aminoacyl acceptor stem with a unique length of 9 base pairs. Within this stem, two base
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e80ed6473a096a509808db1af37673
https://doi.org/10.1074/jbc.270.31.18570
https://doi.org/10.1074/jbc.270.31.18570
Autor:
Karl-Heinz Wiederhold, E Maguire, D Hunziker, Christine Sturchler-Pierrat, K Carver, H.-P Schlecht, Mathias Jucker, Matthias Staufenbiel, Bernd Sommer, R Bergmann, Dorothee Abramowski, Peter H. Kelly, Luca Bondolfi
Publikováno v:
Neurobiology of aging. 24(2)
Transgenic APP23 mice expressing human APP(751) with the K670N/M671L mutation, were compared at ages 3, 18 or 25 months to non-transgenic littermates in passive avoidance and in a small and large Morris maze. The task in the smaller pool habituated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc9f65fb43c2d40339de46fb6f73dd12
https://pubmed.ncbi.nlm.nih.gov/12498971
https://pubmed.ncbi.nlm.nih.gov/12498971
Autor:
Matthias Staufenbiel, Diana Baumann, Markus Rudin, Thomas Mueggler, Martin Rausch, Christine Sturchler-Pierrat
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(16)
APP23 transgenic mice overexpressing amyloid precursor protein (APP(751)) reproduce neuropathological changes associated with Alzheimer's disease such as high levels of amyloid plaques, cerebral amyloid angiopathy, and associated vascular pathologies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b1f58f59a2035edb75e2ccc1348486
https://pubmed.ncbi.nlm.nih.gov/12177216
https://pubmed.ncbi.nlm.nih.gov/12177216