Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Christine Spee"'
Autor:
Parameswaran Gangadharan Sreekumar, Feng Su, Christine Spee, Elise Hong, Ravikiran Komirisetty, Eduardo Araujo, Steven Nusinowitz, Srinivasa T. Reddy, Ram Kannan
Publikováno v:
Antioxidants, Vol 12, Iss 10, p 1820 (2023)
Although AMD is a complex disease, oxidative stress is a crucial contributor to its development, especially in view of the higher oxygen demand of the retina. Paraoxonase 2 (PON2) is a ubiquitously and constitutively expressed antioxidant protein tha
Externí odkaz:
https://doaj.org/article/517053e86c7a4954b05dceae92c78720
Autor:
Parameswaran Gangadharan Sreekumar, Feng Su, Christine Spee, Eduardo Araujo, Steven Nusinowitz, Srinivasa T Reddy, Ram Kannan
Publikováno v:
Cells, Vol 12, Iss 1, p 43 (2022)
Lipid peroxidation from oxidative stress is considered a major contributor to age-related macular degeneration (AMD). The retina is abundant with circulating low-density lipoproteins (LDL), which are taken up by LDL receptor (LDLR) in the RPE and Mü
Externí odkaz:
https://doaj.org/article/8ccc4a6d0b534aeb9e23b988d724b30e
Publikováno v:
Antioxidants, Vol 11, Iss 10, p 2080 (2022)
Proliferative Vitreoretinopathy (PVR) is a refractory retinal disease whose primary pathogenesis involves the epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells. At present, there is no effective treatment other than su
Externí odkaz:
https://doaj.org/article/27098dc2ac4a4c2eb84e41720ccd89fd
Publikováno v:
Antioxidants, Vol 9, Iss 5, p 411 (2020)
Mitochondrial glutathione (mGSH) is critical for cell survival. We recently reported the localization of OGC (SLC25A11) and DIC (SLC25A10) in hRPE. Herein, we investigated the suppression of OGC and DIC and the effect of αB crystallin chaperone pept
Externí odkaz:
https://doaj.org/article/35d1c5b78c7c4f6a9f8712e3a6ca76c9
Autor:
Feng Su, Christine Spee, Eduardo Araujo, Eric Barron, Mo Wang, Caleb Ghione, David R. Hinton, Steven Nusinowitz, Ram Kannan, Srinivasa T. Reddy, Robin Farias-Eisner
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4807 (2019)
Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD. Oxidative stress plays a key role in the development of AMD. We generated a ch
Externí odkaz:
https://doaj.org/article/5a644b11b8554cfdaa9bac3458da1c6b
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e98275 (2014)
Age-related macular degeneration (AMD) is a leading cause of blindness in the developed world. The retinal pigment epithelium (RPE) is a critical site of pathology in AMD and αB crystallin expression is increased in RPE and associated drusen in AMD.
Externí odkaz:
https://doaj.org/article/62f3fe593fbc47c9ab034115b3320fb7
Autor:
Parameswaran G Sreekumar, Christine Spee, Stephen J Ryan, Susan P C Cole, Ram Kannan, David R Hinton
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33420 (2012)
Absence of α-crystallins (αA and αB) in retinal pigment epithelial (RPE) cells renders them susceptible to oxidant-induced cell death. We tested the hypothesis that the protective effect of α-crystallin is mediated by changes in cellular glutathi
Externí odkaz:
https://doaj.org/article/322fccd70f4c4e4c91e0bbbe39ccaacb
Autor:
Parameswaran G Sreekumar, Ram Kannan, Mizuki Kitamura, Christine Spee, Ernesto Barron, Stephen J Ryan, David R Hinton
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e12578 (2010)
αB crystallin is a chaperone protein with anti-apoptotic and anti-inflammatory functions and has been identified as a biomarker in age-related macular degeneration. The purpose of this study was to determine whether αB crystallin is secreted from r
Externí odkaz:
https://doaj.org/article/abae292a0023439cb331d940bb7b2b15
Autor:
Shikun He, Dean Eliott, Elliott H. Sohn, Chunhua Jiao, Christine Spee, Kai Wang, Robert F. Mullins, David R. Hinton
Publikováno v:
Retina. 39:265-273
We sought to characterize the angiofibrotic and apoptotic effects of vascular endothelial growth factor (VEGF)-inhibition on fibrovascular epiretinal membranes in eyes with traction retinal detachment because of proliferative diabetic retinopathy.Mem
Autor:
Parameswaran G. Sreekumar, David R. Hinton, Zhe Li, J. Andrew MacKay, Christine Spee, Ram Kannan, Wan Wang
Publikováno v:
Journal of Controlled Release. 283:94-104
Age-related macular degeneration (AMD) is the leading cause of severe and irreversible central vision loss, and the primary site of AMD pathology is the retinal pigment epithelium (RPE). Geographic atrophy (GA) is an advanced form of AMD characterize