Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christine Spalding"'
Autor:
Michele, Woolbert, Christine, Spalding, Ninet, Sinaii, Brooke K, Decker, Tara N, Palmore, David K, Henderson
Publikováno v:
Infection control and hospital epidemiology.
The objective of this study was to analyze the frequency and rates of community respiratory virus infections detected in NIH Clinical Center (NIHCC) patients from January 2015 through March 2021, comparing the trends before and during the COVID-19 pa
Publikováno v:
Open Forum Infectious Diseases
Background During the first year of the COVID-19 pandemic, nonpharmaceutical interventions had a broad impact on viral transmission apart from SARS-CoV-2. The NIH Clinical Center has used the BioFire FilmArray multiplex PCR respiratory pathogen panel
Autor:
Shamira J. Shallom, Christina M. Kenosky, Seyedmojtaba Syedmoussavi, Tara N. Palmore, Christine Spalding, Zelazny Adrian, Julia A. Segre
Publikováno v:
Infection Control & Hospital Epidemiology. 41:s112-s113
Background:Candida auris is a highly transmissible healthcare-associated pathogen that can cause severe infection as well as long-lasting colonization. C. auris is often resistant to the antifungals that are commonly used to treat Candida infections,
Autor:
Clay Deming, Christine Spalding, John P. Dekker, Shih-Queen Lee-Lin, Karen M. Frank, Sean Conlan, Tara N. Palmore, Morgan Park, Anna F. Lau, Julia A. Segre, Pamela J. Thomas
Publikováno v:
mBio, Vol 10, Iss 5, p e00652-19 (2019)
mBio, Vol 10, Iss 5 (2019)
mBio
mBio, Vol 10, Iss 5 (2019)
mBio
Antibiotic-resistant bacteria are a serious threat to medically fragile patient populations. The spread of antibiotic resistance through plasmid-mediated mechanisms is of grave concern as it can lead to the conversion of endogenous patient-associated
Autor:
Prabha Chandrasekaran, Nilay Kumar, Mary E. Hanks, Christa S. Zerbe, Elizabeth P. Sampaio, Amy P. Hsu, Steven M. Holland, Ricardo M. La Hoz, Jessica S. Merlin, Brian C. Davis, Nicholas Van Wagoner, Christine Spalding
Publikováno v:
Journal of Allergy and Clinical Immunology. 134:236-239
We identified a novel gain of function mutation in STAT1 in a patient with disseminated Apophysomyces trapeziformis infection who had never had mucocutaneous candidiasis or autoimmunity. To our knowledge this is the first report of a genetic predispo
Autor:
Jordan S. Orange, Janine Daub, Adrian M. Zelazny, Emily M. Mace, Gulbu Uzel, Pamela A. Shaw, Kenneth N. Olivier, Amy P. Hsu, Dennis D. Hickstein, Christine M. Gould, Christine Spalding, Blanche P. Alter, Carmen C. Brewer, Edward W. Cowen, Wenjuan Gu, Jennifer Cuellar-Rodriguez, Neelam Giri, Alexandra F. Freeman, Christa S. Zerbe, Michael A. Spinner, Lauren A. Sanchez, Katherine R. Calvo, Steven M. Holland, Diane C. Arthur, Reginald J. Claypool
Publikováno v:
Blood. 123:809-821
Haploinsufficiency of the hematopoietic transcription factor GATA2 underlies monocytopenia and mycobacterial infections; dendritic cell, monocyte, B, and natural killer (NK) lymphoid deficiency; familial myelodysplastic syndromes (MDS)/acute myeloid
Autor:
Alexandra F. Freeman, Hannelore I. Bax, Reginald J. Claypool, Kenneth N. Olivier, Timothy Jancel, Li Ding, Christa S. Zerbe, Joseph Pechacek, Lisa A. Barnhart, B.E. Marciano, Amy P. Hsu, Christine Spalding, Elizabeth P. Sampaio, Ervand Kristosturyan, Cathleen Frein, Victoria L. Anderson, Lisa Boris, S.M. Holland
Publikováno v:
Journal of Clinical Immunology, 33(5), 991-1001. Springer New York
Patients with deficiency in the interferon gamma receptor (IFN-gamma R) are unable to respond properly to IFN-gamma and develop severe infections with nontuberculous mycobacteria (NTM). IFN-gamma and IFN-alpha are known to signal through STAT1 and ac
Autor:
Christine Spalding, Dalton L. Dias, Amy P. Hsu, Steven M. Holland, Elizabeth P. Sampaio, Ervand Kristosturyan, Li Ding, Gulbu Uzel, Michelle L. Paulson, Hannelore I. Bax, Prabha Chandrasekaran, Joseph Pechacek, Elizabeth J. McFarland
Publikováno v:
Journal of Clinical Immunology, 32(4), 681-689. Springer New York
STAT1 is a key component of Interferon (IFN)-gamma and IFN-alpha signaling and mediates protection against mycobacteria, fungal, viral infections, and cancer. Dominant negative inhibitory as well as gain of function heterozygous STAT1 mutations demon
Autor:
Christine Spalding, Ninet Sinaii, John P. Dekker, David K. Henderson, Brooke K. Decker, Tara N. Palmore, Anna Frances Lau, Julia A Segre, Karen M. Frank, Sean Conlan
Publikováno v:
Clinical Microbiology and Infection. 24:82.e1-82.e4
Objectives This study aims to assess the association between patient contact and intestinal carriage of multidrug-resistant organisms (MDRO) by sampling healthcare personnel (HCP) and staff without patient contact. Methods For this observational stud
Autor:
Christine Spalding, Dat Q. Tran, Deborah D. Glass, Gulbu Uzel, Dirk A. Darnell, Ethan M. Shevach, Steven M. Holland
Publikováno v:
The Journal of Immunology. 182:2929-2938
FOXP3+ regulatory T cells (Tregs) are central to the maintenance of self-tolerance and immune homeostasis. The mechanisms of action and cellular targets for Treg-mediated suppression remain controversial. The critical adhesion molecules utilized by T