Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christine Sastri"'
Autor:
Hui-Ling Wang, Kristin L. Andrews, Shon K. Booker, Jude Canon, Victor J. Cee, Frank Chavez, Yuping Chen, Heather Eastwood, Nadia Guerrero, Brad Herberich, Dean Hickman, Brian A. Lanman, Jimmy Laszlo, Matthew R. Lee, J. Russell Lipford, Bethany Mattson, Christopher Mohr, Yen Nguyen, Mark H. Norman, Liping H. Pettus, David Powers, Anthony B. Reed, Karen Rex, Christine Sastri, Nuria Tamayo, Paul Wang, Jeffrey T. Winston, Bin Wu, Qiong Wu, Tian Wu, Ryan P. Wurz, Yang Xu, Yihong Zhou, Andrew S. Tasker
Publikováno v:
Journal of Medicinal Chemistry. 62:1523-1540
Pim kinases are a family of constitutively active serine/threonine kinases that are partially redundant and regulate multiple pathways important for cell growth and survival. In human disease, high expression of the three Pim isoforms has been implic
Autor:
Mercedesz Balazs, Christina Krupka, Ryan Case, Dan A. Rock, Brendon Frank, Tara Arvedson, Sascha Haubner, Michael von Bergwelt-Baildon, Rebecca Goldstein, Michael C. Boyle, Christine Sastri, Priya Koppikar, Angela Coxon, Anja Henn, Bettina Brauchle, Klaus H. Metzeler, Tobias Raum, Christoph Dahlhoff, Joachim Wahl, Christine M. Karbowski, Veit Bücklein, Marion Subklewe, Matthias Friedrich, Karsten Spiekermann, Matthew J. Rardin, Chi-Ming Li
Publikováno v:
Molecular cancer therapeutics. 19(9)
Despite advances in the treatment of acute myeloid leukemia (AML), novel therapies are needed to induce deeper and more durable clinical response. Bispecific T-cell Engager (BiTE) molecules, which redirect patient T cells to lyse tumor cells, are a c
Autor:
Christine Sastri, Noelle Javier, Ryan Wurz, J. Russell Lipford, Hannah Dou, Mei-Chu Lo, Victor J. Cee, John McCarter, Ken Dellamaggiore, Dane Mohl
Publikováno v:
Journal of Medicinal Chemistry. 61:453-461
Proteolysis targeting chimeras (PROTACs) are bispecific molecules containing a target protein binder and an ubiquitin ligase binder connected by a linker. By recruiting an ubiquitin ligase to a target protein, PROTACs promote ubiquitination and prote
Autor:
Heather Eastwood, Andrew Tasker, Yuping Chen, David Powers, Nadia Guerrero, Christopher Mohr, Anthony B. Reed, Jimmy Laszlo, Paul Wang, Yihong Zhou, Ryan Wurz, Mark H. Norman, Karen Rex, Jeffrey T. Winston, Liping H. Pettus, Dean Hickman, Yang Xu, Brian A. Lanman, Tian Wu, Yen Nguyen, Kristin L. Andrews, J. Russell Lipford, Frank Chavez, Hui-Ling Wang, Christine Sastri, Matthew R. Lee, Bethany Mattson, Nuria A. Tamayo, Victor J. Cee, Jie Chen, Bradley J. Herberich, Bin Wu, Shon Booker
Publikováno v:
Journal of Medicinal Chemistry. 59:6407-6430
The high expression of proviral insertion site of Moloney murine leukemia virus kinases (Pim-1, -2, and -3) in cancers, particularly the hematopoietic malignancies, is believed to play a role in promoting cell survival and proliferation while suppres
Autor:
Bettina Brauchle, Tara Arvedson, K. Spiekermann, Sascha Haubner, Christina Krupka, Christine Sastri, Dan A. Rock, M. Subklewe, L. Chi-Ming, Klaus H. Metzeler, K. Cooke, Rebecca Goldstein, M. von Bergwelt-Baildon, Priya Koppikar, Veit Buecklein, O. Thomas
Publikováno v:
HemaSphere. 3:60-61
Autor:
Kristin L. Andrews, Christine Sastri, Victor J. Cee, Bin Wu, Yihong Zhou, Anthony B. Reed, Hui-Ling Wang, Nadia Guerrero, Brian A. Lanman, Yang Xu, Andrew Tasker, J. Russell Lipford, Matthew R. Lee, Frank Chavez, Jeff Winston, Christopher Mohr, Xin Huang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:834-840
The three Pim kinases are a small family of serine/threonine kinases regulating several signaling pathways that are fundamental to tumorigenesis. As such, the Pim kinases are a very attractive target for pharmacological inhibition in cancer therapy.
Autor:
Kristin L. Andrews, J. Russell Lipford, Christine Sastri, Victor J. Cee, Jeff Winston, Andrew Tasker, Liping H. Pettus, Ryan Wurz, Christopher Mohr, Matthew R. Lee, Brian A. Lanman, Bin Wu, Nadia Guerrero, Thomas Nixey, Anthony B. Reed, Hui-Ling Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:775-780
PIM kinases are a family of Ser/Thr kinases that are implicated in tumorigenesis. The discovery of a new class of PIM inhibitors, 5-(1H-indol-5-yl)-1,3,4-thiadiazol-2-amines, is discussed with optimized compounds showing excellent potency against all
Autor:
Christine Sastri, Alice Bakker, Rebecca Goldstein, Yan Zheng, Angela Coxon, Armen Mardiros, Priya Koppikar, Bettina Lindl, Anthony Polverino, Gregor B. Adams, Marion Subklewe, Wu Lawren, Herve Lebrec, Mercedesz Balazs, Dan A. Rock, Chi Ming Li, Tara Arvedson, Mei Gong
Publikováno v:
Cancer Research. 78:2559-2559
Background: FLT3 (CD135) is a receptor tyrosine kinase expressed by hematopoietic progenitor cells, and when activated by ligand binding, FLT3 signaling can induce survival, proliferation and differentiation. Acute myeloid leukemia (AML), an indicati
Autor:
Anthony B. Reed, Christopher Mohr, Jeffrey T. Winston, Yihong Zhou, Tian Wu, Yen Nguyen, Bin Wu, Brian A. Lanman, Victor J. Cee, Ryan Wurz, Liping H. Pettus, Frank Chavez, Karen Rex, Yang Xu, Paul Wang, Kristin L. Andrews, Bradley J. Herberich, Nadia Guerrero, Dean Hickman, Qiong Wu, Andrew Tasker, Jie Chen, Jimmy Laszlo, Christine Sastri, Hui-Ling Wang, Bethany Mattson, J. Russell Lipford, Matthew R. Lee
Publikováno v:
ACS medicinal chemistry letters. 7(4)
The identification of Pim-1/2 kinase overexpression in B-cell malignancies suggests that Pim kinase inhibitors will have utility in the treatment of lymphoma, leukemia, and multiple myeloma. Starting from a moderately potent quinoxaline-dihydropyrrol
Autor:
Claire L. M. Jackson, Thomas Nixey, Jeff Winston, Nadia Guerrero, Christine Sastri, Jimmy Laszlo, Christopher Mohr, Yihong Zhou, Matthew R. Lee, Andrew Tasker, Kristin L. Andrews, Yang Xu, Yen Nguyen, Anthony B. Reed, Frank Chavez, Brad Herberich, J. Russell Lipford, Victor J. Cee, Liping H. Pettus, Ryan Wurz, Brian A. Lanman, Darren L. Reid, Hui-Ling Wang, Bin Wu, Paul Wang
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(4)
High levels of Pim expression have been implicated in several hematopoietic and solid tumor cancers. These findings suggest that inhibition of Pim signaling by a small molecule Pim-1,2 inhibitor could provide patients with therapeutic benefit. Herein