Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christine S. Pien"'
Autor:
Lia Luus, Richard S.P. Huang, Irawati Kandela, Elden P. Swindell, Wiam Bshara, Walid S. Kamoun, Vasileios Askoxylakis, Jason E. Cain, Dmitri B. Kirpotin, Christine S. Pien, Suresh K. Tipparaju, Carl Morrison, Daryl C. Drummond
Publikováno v:
Cancer Research. 78:5771-5771
Ephrin receptor A2 (EphA2) is a member of the Ephrin-Ephrin receptors cell to cell signaling family of molecules and plays a key role in proliferation, differentiation, and migration. EphA2 is overexpressed in a broad range of cancers, including blad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba8bb00805a40a79dc5cbbce36a49ea4
https://doi.org/10.1158/1538-7445.am2018-5771
https://doi.org/10.1158/1538-7445.am2018-5771
Autor:
Ta-Hsiang Chao, Lijun Xia, Saskia T. C. Neuteboom, Vito J. Palombella, James C. Cusack, Wei Niu, Michael A. Palladino, Rong Liu, Christine S. Pien
Publikováno v:
Clinical Cancer Research. 12:6758-6764
Purpose: In the current study, we examine the effects of a novel proteasome inhibitor, NPI-0052 (salinosporamide A), on proteasome function and nuclear factor-κB activation and evaluate its ability to enhance treatment response in colon cancer xenog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a53ac781391ec9c7ff10e2e4bb416f5
https://doi.org/10.1158/1078-0432.ccr-06-1151
https://doi.org/10.1158/1078-0432.ccr-06-1151
Autor:
Roger H. Pak, Louis Grenier, Julian Adams, Jeffrey K. Tong, James D. Wright, Janid A. Ali, Courtney Penders, Emmanuel Normant, Jens R. Sydor, Jon S. Patterson, Melissa Pink, Jie Ge, Jebecka Hudak, Marlene Dembski, Yilong Zhang, Jim Sang, Christine S. Pien, Caroline N. Woodward, James R. Porter, Margaret Read, John A. Barrett, David Grayzel, Vito J. Palombella
Publikováno v:
Proceedings of the National Academy of Sciences. 103:17408-17413
Heat shock protein 90 (Hsp90) is an emerging therapeutic target of interest for the treatment of cancer. Its role in protein homeostasis and the selective chaperoning of key signaling proteins in cancer survival and proliferation pathways has made it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f11c8483df52f90a7ab65229a46a8d6
https://doi.org/10.1073/pnas.0608372103
https://doi.org/10.1073/pnas.0608372103
Autor:
Peter J. Elliott, Owen A. O'Connor, Stephanie Stahl, Steven L. Soignet, Robert Z. Orlowski, Julian Adams, Natalie D. Depcik-Smith, Roberto Guerciolini, Steven C. Novick, Mary Jo Lehman, Jessica K. Anderson, Christine S. Pien, Thomas E. Stinchcombe, Beverly S. Mitchell, Albert S. Baldwin, Dixie Lee Esseltine, Thomas C. Shea, Rita Bhagat
Publikováno v:
Journal of Clinical Oncology. 20:4420-4427
PURPOSE: To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), and pharmacodynamics (PD) of the proteasome inhibitor bortezomib (previously known as PS-341) in patients with refractory hematologic malignancies. PATIENTS AND MET
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f17e103047888bf8c484868879fdb90e
https://doi.org/10.1200/jco.2002.01.133
https://doi.org/10.1200/jco.2002.01.133
Publikováno v:
Journal of Experimental Animal Science. 42:65-83
Summary We characterized atherosclerotic lesions in Syrian F 1 B hamsters fed a diet high in saturated fat and cholesterol. Total cholesterol, non-high-density lipoprotein cholesterol, and triglycerides were significantly higher for treated animals t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fd8453c9adcbe3be3992d0fae385616
https://doi.org/10.1016/s0939-8600(02)80009-8
https://doi.org/10.1016/s0939-8600(02)80009-8
Autor:
Gang Sun, Zhaohua Richard Huang, Andrew J. Sawyer, Walid S. Kamoun, Sergey V. Kozin, Alexander Koshkaryev, Patrick Reynolds, Vasileios Askoxylakis, Suresh K. Tipparaju, Lia Luus, Hannah Xu, Samantha Merrigan, Dmitri B. Kirpotin, Christine S. Pien, Daryl C. Drummond
Publikováno v:
Cancer Research. 77:3096-3096
Platinum-taxane combinations are widely used to treat solid tumors either in first or later lines of therapy. While effective in many settings, platinum-taxane combinatorial regimens are limited by toxicities. We have recently developed an antibody d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e75a5eac8d2015aed081523ec5febd78
https://doi.org/10.1158/1538-7445.am2017-3096
https://doi.org/10.1158/1538-7445.am2017-3096
Autor:
Julian Adams, Eric S. Lightcap, Christine S. Pien, Peter J. Elliott, Vincent Chau, Teresa A. McCormack
Publikováno v:
Clinical Chemistry. 46:673-683
Background: PS-341, a selective inhibitor of the proteasome, currently is under evaluation as an anticancer agent in multiple phase I clinical trials. In animal-model studies, PS-341 was rapidly removed from the vascular compartment and distributed w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::769cfd42760ab306b43815807a3ce89a
https://doi.org/10.1093/clinchem/46.5.673
https://doi.org/10.1093/clinchem/46.5.673
Publikováno v:
Journal of Allergy and Clinical Immunology. 104:294-300
Background: Nuclear factor-κB (NF-κB) is a critical transcription factor required for the regulation of many genes involved in inflammatory responses to noxious stimuli. On activation, NF-κB induces the transcription of numerous proinflammatory cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c693dbaaa2bd764ea84b634588c0d275
https://doi.org/10.1016/s0091-6749(99)70369-6
https://doi.org/10.1016/s0091-6749(99)70369-6
Autor:
Alexander Koshkaryev, Walid S. Kamoun, Birgit Schoeberl, Zhaohua Richard Huang, James D. Marks, Kenneth R. Olivier, Christine S. Pien, Tad Kornaga, Daryl C. Drummond, Gerald J. Fetterly, Dmitri B. Kirpotin, Charles O. Noble, Suresh K. Tipparaju, Shinji Oyama, Sarah S. Schihl, Mark E. Hayes
Publikováno v:
Cancer Research. 76:3912-3912
Taxanes are widely used to treat solid tumors either in the curative or palliative setting, in first or later lines of therapy. Analysis of docetaxel dose-response relationship strongly suggests that a higher dose would lead to high response, however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7f364e758686b143203440947d8c885
https://doi.org/10.1158/1538-7445.am2016-3912
https://doi.org/10.1158/1538-7445.am2016-3912
Autor:
Lihui Xu, James D. Marks, Alexander Koshkaryev, Walid S. Kamoun, Alexey Lugovosky, Zhaohua Richard Huang, Christine S. Pien, Dmitri B. Kirpotin, Melissa Geddie, Suresh K. Tipparaju, Shinji Oyama, Lia Luus, Tad Kornaga, Daryl C. Drummond
Publikováno v:
Cancer Research. 76:871-871
Ephrins receptors are cell to cell adhesion molecules that mediate signaling and are implicated in neuronal repulsion, cell migration and angiogenesis. Ephrin receptor A2 (EphA2) is part of the ephrin family and was shown to be overexpressed in sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd7e57a4fdffe31ddc2f0ae70608918f
https://doi.org/10.1158/1538-7445.am2016-871
https://doi.org/10.1158/1538-7445.am2016-871