Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christine S. Muli"'
Autor:
Aaron D. Krabill, Hao Chen, Sajjad Hussain, Chad S. Hewitt, Ryan D. Imhoff, Christine S. Muli, Chittaranjan Das, Paul J. Galardy, Michael K. Wendt, Daniel P. Flaherty
Publikováno v:
Molecules, Vol 26, Iss 5, p 1227 (2021)
The deubiquitinating enzyme (DUB) UCHL1 is implicated in various disease states including neurodegenerative disease and cancer. However, there is a lack of quality probe molecules to gain a better understanding on UCHL1 biology. To this end a study w
Externí odkaz:
https://doaj.org/article/61cafbcea7ac477da7a719f874ab958a
Autor:
Darlene Dela Cruz, Mark Merchant, Frances Shanahan, Christopher J. Sneeringer, Paul Gibbons, Shiva Malek, Michael Siu, Matthew R. Durk, Weiru Wang, John Moffat, Jianping Yin, Thomas Hunsaker, Liu Wendy, Dennis Leung, Ivana Yen, Charles Eigenbrot, Joachim Rudolph, Christine S Muli, Hank La, Brendan T. Parr, Antonio G. DiPasquale, Malcolm P. Huestis, Alberto Gobbi, Christine Orr
Publikováno v:
Journal of Medicinal Chemistry. 64:3940-3955
Optimization of a series of aryl urea RAF inhibitors led to the identification of type II pan-RAF inhibitor GNE-0749 (7), which features a fluoroquinazolinone hinge-binding motif. By minimizing reliance on common polar hinge contacts, this hinge bind
Autor:
Christine S. Muli, Darci J. Trader
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 85:129233
Publikováno v:
Molecular Pharmacology. 98:677-685
Regulator of G protein signaling (RGS) proteins are negative modulators of G protein signaling that have emerged as promising drug targets to improve specificity and reduce side effects of G protein-coupled receptor-related therapies. Several small m
Autor:
William L. PistelII, Erin E. Doherty, Rebecca K. Rowe, Christine S. Muli, Katherine R. Matasci, Sean McIntyre, Abbey R. Rickelmann, John P. Hagen, Travis B. Smith, Hasan Palandoken
Publikováno v:
Tenside Surfactants Detergents. 57:6-12
Sugar oxime ether surfactants are a new class of surfactants produced by the reaction of a sugar with a hydrophobic alkoxyamine, producing an oxime ether linkage. We examined nine examples of this class of surfactants. The sugars used were maltose, s
Autor:
Atul Bhardwaj, Darci J. Trader, Yizhou Zhao, Rachel A Coleman, Timothy R. Newhouse, Christine S. Muli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:420-423
Proteasome-mediated degradation of proteins is a vital cellular process and is performed by the ubiquitin-dependent proteasome system (UPS) and the ubiquitin-independent proteasome system (UIPS). While both systems are necessary to maintain healthy c
Autor:
Malcolm P, Huestis, Darlene, Dela Cruz, Antonio G, DiPasquale, Matthew R, Durk, Charles, Eigenbrot, Paul, Gibbons, Alberto, Gobbi, Thomas L, Hunsaker, Hank, La, Dennis H, Leung, Wendy, Liu, Shiva, Malek, Mark, Merchant, John G, Moffat, Christine S, Muli, Christine J, Orr, Brendan T, Parr, Frances, Shanahan, Christopher J, Sneeringer, Weiru, Wang, Ivana, Yen, Jianping, Yin, Michael, Siu, Joachim, Rudolph
Publikováno v:
Journal of medicinal chemistry. 64(7)
Optimization of a series of aryl urea RAF inhibitors led to the identification of type II pan-RAF inhibitor GNE-0749 (
Autor:
Ryan D Imhoff, Aaron D Krabill, Chad S. Hewitt, Daniel P. Flaherty, Christine S Muli, Paul J. Galardy, Hao Chen, Sajjad Hussain, Chittaranjan Das, Michael K. Wendt
Publikováno v:
Molecules
Volume 26
Issue 5
Molecules, Vol 26, Iss 1227, p 1227 (2021)
Volume 26
Issue 5
Molecules, Vol 26, Iss 1227, p 1227 (2021)
The deubiquitinating enzyme (DUB) UCHL1 is implicated in various disease states including neurodegenerative disease and cancer. However, there is a lack of quality probe molecules to gain a better understanding on UCHL1 biology. To this end a study w
Publikováno v:
Chembiochem
Cells need to synthesize and degrade proteins consistently. Maintaining a balanced level of protein in the cell requires a carefully controlled system and significant energy. Degradation of unwanted or damaged proteins into smaller peptide units can
Dissertation/ Thesis
Autor:
Christine S Muli (14227157)
The proteasome is a multi-catalytic, multiprotein enzymatic machinery that is responsible for most of the protein degradation in the cell. Cellular protein homeostasis through the proteasome is regulated through the ubiquitin-independent or ubiquitin