Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christine S. Fuchs"'
Autor:
Mathias Pickl, Johann H. Sattler, Georg Steinkellner, Karl Gruber, Ferdinand Zepeck, Robert C. Simon, Christine S. Fuchs, Wolfgang Kroutil, Judith E. Farnberger
Publikováno v:
Advanced Synthesis & Catalysis. 360:768-778
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35bea8305c0942a02194c5b329213049
https://doi.org/10.1002/adsc.201701449
https://doi.org/10.1002/adsc.201701449
Autor:
Johann H. Sattler, Ferdinand Zepeck, Nina Richter, Wolfgang Kroutil, Judith E. Farnberger, Christine S. Fuchs, Robert C. Simon
Publikováno v:
Tetrahedron: Asymmetry. 25:284-288
Various enantiocomplementary ω-transaminases (ωTAs) were investigated in kinetic resolution and asymmetric reductive amination reactions to prepare silodosin amine. Whilst the enzymatic kinetic resolution gave moderate to good results with respect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbb5d7f485713fcb0c3bb5eab7c36d3c
https://doi.org/10.1016/j.tetasy.2013.12.012
https://doi.org/10.1016/j.tetasy.2013.12.012
Autor:
Christine S. Fuchs, Wolfgang Kroutil, Joost N. H. Reek, Ferdinand Zepeck, Robert C. Simon, Tatiana Besset, Manuel Hollauf, Maximilian Meissner, Waander Riethorst
Publikováno v:
Advanced Synthesis and Catalysis
Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2014, 356 (10), pp.2257-2265. ⟨10.1002/adsc.201400217⟩
Advanced Synthesis & Catalysis, 356(10), 2257-2265. Wiley-VCH Verlag
Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2014, 356 (10), pp.2257-2265. ⟨10.1002/adsc.201400217⟩
Advanced Synthesis & Catalysis, 356(10), 2257-2265. Wiley-VCH Verlag
The amination of racemic alpha-chiral aldehydes, 2-phenylpropanal derivatives, was investigated employing omega-transaminases. By medium and substrate engineering the optical purity of the resulting β-chiral chiral amine could be enhanced to reach o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702ea1eacc4c67c023ca70d4deafc38b
https://dare.uva.nl/personal/pure/en/publications/dynamic-kinetic-resolution-of-2phenylpropanal-derivatives-to-yield-chiral-primary-amines-via-bioamination(6f7d27b4-c82b-4cdf-a3dd-3301c2e08aa6).html
https://dare.uva.nl/personal/pure/en/publications/dynamic-kinetic-resolution-of-2phenylpropanal-derivatives-to-yield-chiral-primary-amines-via-bioamination(6f7d27b4-c82b-4cdf-a3dd-3301c2e08aa6).html
Autor:
Wolfgang Kroutil, Tanja Knaus, Desiree Pressnitz, Johann H. Sattler, Francesco G. Mutti, Peter Macheroux, Christine S. Fuchs
Publikováno v:
ACS Catalysis
Various (S)-selective and (R)-selective ω-transaminases were investigated for the amination of 1- and 2-tetralone and derivatives as well as of 3- and 4-chromanone. All ketones tested were aminated to give the corresponding enantiopure amines (ee >
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86aa04cdf8ca409b1f3d8df11651ba6c
https://doi.org/10.1021/cs400002d
https://doi.org/10.1021/cs400002d
Autor:
Simon Willies, Matthew D. Truppo, Christopher K. Savile, Jacob M. Janey, Jeffrey C. Moore, Gjalt W. Huisman, Gregory J. Hughes, Francesco G. Mutti, Christine S. Fuchs, Wolfgang Kroutil, Jennifer Hopwood, Richard Lloyd, Nicholas J. Turner, Eun Young Hong, Minho Cha, Hyungdon Yun, Byung‐Gee Kim, S. Stella, Anju Chadha
Publikováno v:
Practical Methods for Biocatalysis and Biotransformations 2. :61-86
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::154fb5d1371241943b18e938cbbf4f5b
https://doi.org/10.1002/9781119943426.ch2
https://doi.org/10.1002/9781119943426.ch2
Autor:
Christine S. Fuchs, Johann H. Sattler, Francesco G. Mutti, Wolfgang Kroutil, Desiree Pressnitz
Publikováno v:
Advanced Synthesis & Catalysis
Four (R)-ω-transaminases originating from Hyphomonas neptunium (HN-ωTA), Aspergillus terreus (AT-ωTA) and Arthrobacter sp. (ArR-ωTA), as well as an evolved transaminase (ArRmut11-ωTA) were successfully employed for the amination of prochiral ket
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6d8aa3e83af7305f6d8cb6c3742dbf
Publikováno v:
European Journal of Organic Chemistry
A short and efficient total synthesis of the alkaloid isosolenopsin and its enantiomer has been achieved. The key step was a ω-transaminase-catalysed regioselective monoamination of the diketone pentadecane-2,6-dione, which was obtained in a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6fb8cd083b1e3e575326b381e0a92204
https://pubmed.ncbi.nlm.nih.gov/25191103
https://pubmed.ncbi.nlm.nih.gov/25191103
Publikováno v:
Bioorganicmedicinal chemistry. 22(20)
Valinol is part of numerous pharmaceuticals and has various other important applications. Optically pure valinol (ee >99%) was prepared employing different ω-transaminases from the corresponding prochiral hydroxy ketone. By the choice of the enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2eb13f0173eb7baa2a344f25a9dc54
https://pubmed.ncbi.nlm.nih.gov/24951100
https://pubmed.ncbi.nlm.nih.gov/24951100
Autor:
Wolfgang Kroutil, Robert C. Simon, Eduardo Busto, Nina Richter, Katharina Tauber, Christine S. Fuchs, Desiree Pressnitz, Eva-Maria Fischereder, Horst Lechner, Ferdinand Zepeck
Publikováno v:
Proceedings of the 15th Brazilian Meeting on Organic Synthesis Proceedings.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca6ed0b8f19b1baaa7adefe60173284e
https://doi.org/10.5151/chempro-15bmos-speech5
https://doi.org/10.5151/chempro-15bmos-speech5
Autor:
Wolfgang, Kroutil, Eva-Maria, Fischereder, Christine S, Fuchs, Horst, Lechner, Francesco G, Mutti, Desiree, Pressnitz, Aashrita, Rajagopalan, Johann H, Sattler, Robert C, Simon, Elina, Siirola
Publikováno v:
Organic Process Research & Development
This account focuses on the application of ω-transaminases, lyases, and oxidases for the preparation of amines considering mainly work from our own lab. Examples are given to access α-chiral primary amines from the corresponding ketones as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9b6ab59cd8c631d3183ca21aaa34b547
https://pubmed.ncbi.nlm.nih.gov/23794796
https://pubmed.ncbi.nlm.nih.gov/23794796