Zobrazeno 1 - 10
of 181
pro vyhledávání: '"Christine S Moravec"'
Autor:
Drew M Nassal, Xiaoping Wan, Haiyan Liu, Danielle Maleski, Angelina Ramirez-Navarro, Christine S Moravec, Eckhard Ficker, Kenneth R Laurita, Isabelle Deschênes
Publikováno v:
eLife, Vol 6 (2017)
Arrhythmogenesis from aberrant electrical remodeling is a primary cause of death among patients with heart disease. Amongst a multitude of remodeling events, reduced expression of the ion channel subunit KChIP2 is consistently observed in numerous ca
Externí odkaz:
https://doaj.org/article/b6bb4391289341408afd11106adb8d98
Autor:
Sathyamangla V Naga Prasad, Manveen K Gupta, Zhong-Hui Duan, Venkata Suresh K Surampudi, Chang-Gong Liu, Ashwin Kotwal, Christine S Moravec, Randall C Starling, Dianne M Perez, Subha Sen, Qingyu Wu, Edward F Plow, Sadashiva Karnik
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0170456 (2017)
It is well established that the gene expression patterns are substantially altered in cardiac hypertrophy and heart failure, however, less is known about the reasons behind such global differences. MicroRNAs (miRNAs) are short non-coding RNAs that ca
Externí odkaz:
https://doaj.org/article/f99d93ba38734e5bb17bbf22a96381fb
Autor:
Prasenjit Prasad Saha, Valentin Gogonea, Wendy Sweet, Maradumane L. Mohan, Khuraijam Dhanachandra Singh, James T. Anderson, Deepthi Mallela, Conner Witherow, Niladri Kar, Kate Stenson, Terri Harford, Michael A. Fischbach, J. Mark Brown, Sadashiva S. Karnik, Christine S. Moravec, Joseph A. DiDonato, Sathyamangla Venkata Naga Prasad, Stanley L. Hazen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Allosteric modulation is a central mechanism for metabolic regulation but has yet to be described for a gut microbiota-host interaction. Phenylacetylglutamine (PAGln), a gut microbiota-derived metabolite, has previously been clinically assoc
Externí odkaz:
https://doaj.org/article/135a6fb0bc4149b78a90558a91ecc051
Autor:
J Gustav Smith, Janine F Felix, Alanna C Morrison, Andreas Kalogeropoulos, Stella Trompet, Jemma B Wilk, Olof Gidlöf, Xinchen Wang, Michael Morley, Michael Mendelson, Roby Joehanes, Symen Ligthart, Xiaoyin Shan, Joshua C Bis, Ying A Wang, Marketa Sjögren, Julius Ngwa, Jeffrey Brandimarto, David J Stott, David Aguilar, Kenneth M Rice, Howard D Sesso, Serkalem Demissie, Brendan M Buckley, Kent D Taylor, Ian Ford, Chen Yao, Chunyu Liu, CHARGE-SCD consortium, EchoGen consortium, QT-IGC consortium, CHARGE-QRS consortium, Nona Sotoodehnia, Pim van der Harst, Bruno H Ch Stricker, Stephen B Kritchevsky, Yongmei Liu, J Michael Gaziano, Albert Hofman, Christine S Moravec, André G Uitterlinden, Manolis Kellis, Joyce B van Meurs, Kenneth B Margulies, Abbas Dehghan, Daniel Levy, Björn Olde, Bruce M Psaty, L Adrienne Cupples, J Wouter Jukema, Luc Djousse, Oscar H Franco, Eric Boerwinkle, Laurie A Boyer, Christopher Newton-Cheh, Javed Butler, Ramachandran S Vasan, Thomas P Cappola, Nicholas L Smith
Publikováno v:
PLoS Genetics, Vol 12, Iss 5, p e1006034 (2016)
Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in pati
Externí odkaz:
https://doaj.org/article/a9d75c26c69d4565b9910119307e9517
Autor:
Shamone R Gore-Panter, Jeffery Hsu, Peter Hanna, A Marc Gillinov, Gosta Pettersson, David W Newton, Christine S Moravec, David R Van Wagoner, Mina K Chung, John Barnard, Jonathan D Smith
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86245 (2014)
Atrial Fibrillation (AF), the most common sustained arrhythmia, has a strong genetic component, but the mechanism by which common genetic variants lead to increased AF susceptibility is unknown. Genome-wide association studies (GWAS) have identified
Externí odkaz:
https://doaj.org/article/11583adc0628477e880cb0c5ee9acee5
Autor:
Anna P Pilbrow, Lasse Folkersen, John F Pearson, Chris M Brown, Les McNoe, Nancy M Wang, Wendy E Sweet, W H Wilson Tang, Michael A Black, Richard W Troughton, A Mark Richards, Anders Franco-Cereceda, Anders Gabrielsen, Per Eriksson, Christine S Moravec, Vicky A Cameron
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39574 (2012)
Genome-wide association studies have identified a coronary artery disease (CAD) risk locus in a non-coding region at 9p21.3, the nearest genes being CDKN2A and CDKN2B. To understand the pathways by which this locus might influence CAD susceptibility,
Externí odkaz:
https://doaj.org/article/b227e4d2771f4468a9b7acaf2e702444
Autor:
Xiaoqian Wu, Huan Liu, Alan Brooks, Suowen Xu, Jinque Luo, Rebbeca Steiner, Deanne M. Mickelsen, Christine S. Moravec, Alexis D. Jeffrey, Eric M. Small, Zheng Gen Jin
Publikováno v:
Circulation Research. 131:926-943
Background: Heart failure with preserved ejection fraction (HFpEF) is a growing health problem without effective therapies. Epidemiological studies indicate that diabetes is a strong risk factor for HFpEF, and about 45% of patients with HFpEF are suf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d912da49d46e330be851f178f187a0cd
https://doi.org/10.1161/circresaha.121.318988
https://doi.org/10.1161/circresaha.121.318988
Autor:
Maryam Sharifi-Sanjani, Mariah Berman, Dmitry Goncharov, Mohammad Alhamaydeh, Theodore Guy Avolio, Jeffrey Baust, Baojun Chang, Ahasanul Kobir, Mark Ross, Claudette St. Croix, Seyed Mehdi Nouraie, Charles F. McTiernan, Christine S. Moravec, Elena Goncharova, Imad Al Ghouleh
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 6164 (2021)
Left ventricular (LV) heart failure (HF) is a significant and increasing cause of death worldwide. HF is characterized by myocardial remodeling and excessive fibrosis. Transcriptional co-activator Yes-associated protein (Yap), the downstream effector
Externí odkaz:
https://doaj.org/article/dcee4e1c788d48fdb859c3873db78630
Publikováno v:
Am J Physiol Heart Circ Physiol
Mutations to the sarcomere-localized cochaperone protein Bcl2-associated athanogene 3 (BAG3) are associated with dilated cardiomyopathy (DCM) and display greater penetrance in male patients. Decreased protein expression of BAG3 is also associated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99621cd55c11dea09475ba1e98f051c6
https://doi.org/10.1152/ajpheart.00419.2020
https://doi.org/10.1152/ajpheart.00419.2020
Autor:
Armen Abnousi, Christine S. Moravec, Michael Morley, W.H. Wilson Tang, Chia-Feng Liu, Ming Hu, Peter Bazeley, Ying Ni
Publikováno v:
J Mol Cell Cardiol
Background Acetylation and methylation of histones alter the chromatin structure and accessibility that affect transcriptional regulators binding to enhancers and promoters. The binding of transcriptional regulators enables the interaction between en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4524e79a419873899c2636d6325a21cf
https://doi.org/10.1016/j.yjmcc.2020.06.001
https://doi.org/10.1016/j.yjmcc.2020.06.001