Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Christine Rothe"'
Autor:
Martin Siegemund, Prajakta Oak, Eva-Maria Hansbauer, Andrea Allersdorfer, Karoline Utschick, Alexandra Winter, Christina Grasmüller, Gunther Galler, Jan-Peter Mayer, Benjamin Weiche, Josef Prassler, Roland E. Kontermann, Christine Rothe
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Anticalin® proteins have been proven as versatile clinical stage biotherapeutics. Due to their small size (∼20 kDa), they harbor a short intrinsic plasma half-life which can be extended, e.g., by fusion with IgG or Fc. However, for antagonism of c
Externí odkaz:
https://doaj.org/article/b0e0d1dd68aa479293074992f3f52fe4
Autor:
Shane Anthony Olwill, Louis Matis, Christine Rothe, Ulrich Moebius, Julia Schüler, Gabriele Matschiner, Alexander Wiedenmann, Andrea Allersdorfer, Corinna Schlosser, Manuela Carola Dürr, Sven Berger, Thomas J. Jaquin, Rachida Siham Bel Aiba, Marlon J. Hinner
Figure S1: PRS-343 specificity for 4-1BB within TNF receptor superfamily. Seven recombinant human TNF receptor superfamily proteins were purchased from Sino Biological (4-1BB: 10041-H08H, RANK: 16078-H08H, GITR: 13643-H08H, Ox40: 10481-H08H) or R&D S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83ec8707cf57011c6e9caa7b6236ec00
https://doi.org/10.1158/1078-0432.22474368
https://doi.org/10.1158/1078-0432.22474368
Autor:
Shane A. Olwill, Veronique Blanc, Christine Rothe, Rachida S. Bel Aiba, Markus Zettl, Maximilien Grandclaudon, Matthieu Riviere, Celine Sancerne, Birgit Bossenmaier, Alix Scholer-Dahirel, Helene Lelievre, Marleen Richter, Eva-Maria Hansbauer, Catherine Gallou, Thomas J. Jaquin, Aizea Morales-Kastresana, Lucia Pattarini, Marina Pavlidou, Janet K. Peper-Gabriel
Supplementary Table from The PD-L1/4-1BB Bispecific Antibody–Anticalin Fusion Protein PRS-344/S095012 Elicits Strong T-Cell Stimulation in a Tumor-Localized Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09683939ca1968a7429fc3bd2a7978ed
https://doi.org/10.1158/1078-0432.22482120.v1
https://doi.org/10.1158/1078-0432.22482120.v1
Autor:
Shane A. Olwill, Veronique Blanc, Christine Rothe, Rachida S. Bel Aiba, Markus Zettl, Maximilien Grandclaudon, Matthieu Riviere, Celine Sancerne, Birgit Bossenmaier, Alix Scholer-Dahirel, Helene Lelievre, Marleen Richter, Eva-Maria Hansbauer, Catherine Gallou, Thomas J. Jaquin, Aizea Morales-Kastresana, Lucia Pattarini, Marina Pavlidou, Janet K. Peper-Gabriel
Supplementary Figure from The PD-L1/4-1BB Bispecific Antibody–Anticalin Fusion Protein PRS-344/S095012 Elicits Strong T-Cell Stimulation in a Tumor-Localized Manner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03beeeee9f6afdb49943e64a9999656f
https://doi.org/10.1158/1078-0432.22482126
https://doi.org/10.1158/1078-0432.22482126
Autor:
Shane Anthony Olwill, Louis Matis, Christine Rothe, Ulrich Moebius, Julia Schüler, Gabriele Matschiner, Alexander Wiedenmann, Andrea Allersdorfer, Corinna Schlosser, Manuela Carola Dürr, Sven Berger, Thomas J. Jaquin, Rachida Siham Bel Aiba, Marlon J. Hinner
Supplementary Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3495ff05e7ee566eb27ac20741bac6e0
https://doi.org/10.1158/1078-0432.22474365.v1
https://doi.org/10.1158/1078-0432.22474365.v1
Autor:
Shane Anthony Olwill, Louis Matis, Christine Rothe, Ulrich Moebius, Julia Schüler, Gabriele Matschiner, Alexander Wiedenmann, Andrea Allersdorfer, Corinna Schlosser, Manuela Carola Dürr, Sven Berger, Thomas J. Jaquin, Rachida Siham Bel Aiba, Marlon J. Hinner
Purpose:4-1BB (CD137) is a key costimulatory immunoreceptor and promising therapeutic target in cancer. To overcome limitations of current 4-1BB–targeting antibodies, we have developed PRS-343, a 4-1BB/HER2 bispecific molecule. PRS-343 is designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390c0f170adb08f2657eceb656261c87
https://doi.org/10.1158/1078-0432.c.6528768
https://doi.org/10.1158/1078-0432.c.6528768
Autor:
Shane A. Olwill, Veronique Blanc, Christine Rothe, Rachida S. Bel Aiba, Markus Zettl, Maximilien Grandclaudon, Matthieu Riviere, Celine Sancerne, Birgit Bossenmaier, Alix Scholer-Dahirel, Helene Lelievre, Marleen Richter, Eva-Maria Hansbauer, Catherine Gallou, Thomas J. Jaquin, Aizea Morales-Kastresana, Lucia Pattarini, Marina Pavlidou, Janet K. Peper-Gabriel
Purpose:While patients responding to checkpoint blockade often achieve remarkable clinical responses, there is still significant unmet need due to resistant or refractory tumors. A combination of checkpoint blockade with further T-cell stimulation me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e18ed00c28b4f873d320cdf7bc8fa20
https://doi.org/10.1158/1078-0432.c.6530826
https://doi.org/10.1158/1078-0432.c.6530826
Autor:
Janet K. Peper-Gabriel, Marina Pavlidou, Lucia Pattarini, Aizea Morales-Kastresana, Thomas J. Jaquin, Catherine Gallou, Eva-Maria Hansbauer, Marleen Richter, Helene Lelievre, Alix Scholer-Dahirel, Birgit Bossenmaier, Celine Sancerne, Matthieu Riviere, Maximilien Grandclaudon, Markus Zettl, Rachida S. Bel Aiba, Christine Rothe, Veronique Blanc, Shane A. Olwill
Publikováno v:
Clinical Cancer Research. 28:3387-3399
Purpose:While patients responding to checkpoint blockade often achieve remarkable clinical responses, there is still significant unmet need due to resistant or refractory tumors. A combination of checkpoint blockade with further T-cell stimulation me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e236f780367f983b00cd12e64e0aed
https://doi.org/10.1158/1078-0432.ccr-21-2762
https://doi.org/10.1158/1078-0432.ccr-21-2762
Autor:
Aizea, Morales-Kastresana, Martin, Siegemund, Stefan, Haak, Janet, Peper-Gabriel, Vanessa, Neiens, Christine, Rothe
Publikováno v:
International review of cell and molecular biology. 369
Anticalin proteins are a novel class of clinical-stage biopharmaceuticals with high potential in various disease areas. Anticalin proteins, derived from extracellular human lipocalins are single-chain proteins, with a highly stable structure that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::173032e600f0769b9de8c7025702f159
https://pubmed.ncbi.nlm.nih.gov/35777866
https://pubmed.ncbi.nlm.nih.gov/35777866
Autor:
Aizea Morales-Kastresana, Martin Siegemund, Stefan Haak, Janet Peper-Gabriel, Vanessa Neiens, Christine Rothe
Publikováno v:
International Review of Cell and Molecular Biology ISBN: 9780323994026
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf9d4d619091b1926dee40362a3db6e9
https://doi.org/10.1016/bs.ircmb.2022.03.009
https://doi.org/10.1016/bs.ircmb.2022.03.009