Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christine Ralf"'
Autor:
Isabel E. Wassing, Emily Graham, Xanita Saayman, Lucia Rampazzo, Christine Ralf, Andrew Bassett, Fumiko Esashi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
RAD51 is a well known player of DNA repair and homologous recombination. Here the authors reveal a function for RAD51 in protecting under-replicated DNA in mitotic human cells, promoting mitotic DNA synthesis (MiDAS) and successful chromosome segrega
Externí odkaz:
https://doaj.org/article/edc529610cfe4e3884a66076ba7caeea
Autor:
Keiko Yata, Jean-Yves Bleuyard, Ryuichiro Nakato, Christine Ralf, Yuki Katou, Rebekka A. Schwab, Wojciech Niedzwiedz, Katsuhiko Shirahige, Fumiko Esashi
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1547-1559 (2014)
Numerous human genome instability syndromes, including cancer, are closely associated with events arising from malfunction of the essential recombinase Rad51. However, little is known about how Rad51 is dynamically regulated in human cells. Here, we
Externí odkaz:
https://doaj.org/article/b74b4e6518364c7ea181813928cbc69e
Autor:
Christine Ralf, Emily Graham, Isabel E. Wassing, Lucia Rampazzo, Andrew R. Bassett, Xanita Saayman, Fumiko Esashi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The RAD51 recombinase plays critical roles in safeguarding genome integrity, which is fundamentally important for all living cells. While interphase functions of RAD51 in maintaining genome stability are well-characterised, its role in mitosis remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9969e0a3cfdf190971e8247af2890f2
https://doi.org/10.1038/s41467-021-25643-y
https://doi.org/10.1038/s41467-021-25643-y
Autor:
Andrew R. Bassett, Lucia Rampazzo, Xanita Saayman, Fumiko Esashi, Isabel E. Wassing, Christine Ralf
The RAD51 recombinase plays critical roles in safeguarding genome integrity, which is fundamentally important for all living cells. While interphase functions of RAD51 in repairing broken DNA and protecting stalled replication forks are well characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd632ccac3e6b52f8e390230ea1e74e8
https://doi.org/10.1101/2020.08.11.246231
https://doi.org/10.1101/2020.08.11.246231
Autor:
Daniela Rhodes, Yuki Katou, Jean-Yves Bleuyard, Katsuhiko Shirahige, Anthony M. Couturier, Ryuichiro Nakato, Fumiko Esashi, Timothy C. Humphrey, Christine Ralf, Svenja Hester, Daniel Dominguez, Marjorie Fournier
The partner and localiser of BRCA2 (PALB2) plays important roles in the maintenance of genome integrity and protection against cancer. Although PALB2 is commonly described as a repair factor recruited to sites of DNA breaks, recent studies provide ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674acffb3465190c23cc49c97f4644a8
https://ora.ox.ac.uk/objects/uuid:d28909c5-02f6-4415-9e85-7cb1629b2840
https://ora.ox.ac.uk/objects/uuid:d28909c5-02f6-4415-9e85-7cb1629b2840
Publikováno v:
The Journal of biological chemistry. 281(32)
Homozygous inactivation of BLM gives rise to Bloom's syndrome, a disorder associated with genomic instability and cancer predisposition. BLM encodes a member of the RecQ DNA helicase family that is required for the maintenance of genome stability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35462ada5317892665780724ca9a6aea
https://pubmed.ncbi.nlm.nih.gov/16766518
https://pubmed.ncbi.nlm.nih.gov/16766518
Autor:
Vilhelm A. Bohr, Christine Ralf, James L. Keck, Pavel Janscak, Kok-Lung Chan, Douglas A. Bernstein, Leonard Wu, Alessandro Vindigni, Ian D. Hickson, Patrick L. Garcia
Bloom's syndrome is a hereditary cancer-predisposition disorder resulting from mutations in the BLM gene. In humans, BLM encodes one of five members of the RecQ helicase family. One function of BLM is to act in concert with topoisomerase IIIalpha (TO
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f066d7e915ecbee2d8cf1ef233775c62
https://europepmc.org/articles/PMC1176466/
https://europepmc.org/articles/PMC1176466/
Autor:
Fournier, Marjorie, Rodrigue, Amélie, Milano, Larissa, Bleuyard, Jean-Yves, Couturier, Anthony M., Wall, Jacob, Ellins, Jessica, Hester, Svenja, Smerdon, Stephen J., Tora, László, Masson, Jean-Yves, Esashi, Fumiko
Publikováno v:
eLife; 11/17/2022, p1-34, 34p
Autor:
Wassing, Isabel E., Graham, Emily, Saayman, Xanita, Rampazzo, Lucia, Ralf, Christine, Bassett, Andrew, Esashi, Fumiko
Publikováno v:
Nature Communications; 9/10/2021, Vol. 12 Issue 1, p1-17, 17p
Autor:
Jonas Radl
The monograph disseminates the very topical issue of retirement and its timing as the key to one of the greatest challenges facing ageing societies. Postponing retirement is now almost universally regarded as indispensable in order to relieve Europea