Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Christine Pierrot"'
Autor:
Aline Fréville, Bénédicte Gnangnon, Annie Z. Tremp, Caroline De Witte, Katia Cailliau, Alain Martoriati, El Moukthar Aliouat, Priyanka Fernandes, Cerina Chhuon, Olivier Silvie, Sabrina Marion, Ida Chiara Guerrera, Johannes T. Dessens, Christine Pierrot, Jamal Khalife
Publikováno v:
Open Biology, Vol 12, Iss 8 (2022)
Protein phosphatase 1 (PP1) is a key enzyme for Plasmodium development. However, the detailed mechanisms underlying its regulation remain to be deciphered. Here, we report the functional characterization of the Plasmodium berghei leucine-rich repeat
Externí odkaz:
https://doaj.org/article/449b50bd714546fb85baee771f03edd7
Autor:
Aline Fréville, Bénédicte Gnangnon, Asma S. Khelifa, Mathieu Gissot, Jamal Khalife, Christine Pierrot
Publikováno v:
Microorganisms, Vol 10, Iss 3, p 585 (2022)
Parasites belonging to the Apicomplexa phylum still represent a major public health and world-wide socioeconomic burden that is greatly amplified by the spread of resistances against known therapeutic drugs. Therefore, it is essential to provide the
Externí odkaz:
https://doaj.org/article/c075578c0b7d4dd8ab1735d3c33ca589
Autor:
Caroline De Witte, El Moukhtar Aliouat, Cerina Chhuon, Ida Chiara Guerrera, Christine Pierrot, Jamal Khalife
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1069 (2022)
Malaria parasites require multiple phosphorylation and dephosphorylation steps to drive signaling pathways for proper differentiation and transformation. Several protein phosphatases, including protein phosphatase 1 (PP1), one of the main dephosphory
Externí odkaz:
https://doaj.org/article/9b83c2c69fa84eeba2478b920354213c
Publikováno v:
Bio-Protocol, Vol 10, Iss 11 (2020)
The study of host/pathogen interactions at the cellular level during Plasmodium intra-erythrocytic cycle requires differential extraction techniques aiming to analyze the different compartments of the infected cell. Various protocols have been propos
Externí odkaz:
https://doaj.org/article/3ecb9056d53d48dbbe12476ba5833b6e
Autor:
Thomas Hollin, Caroline De Witte, Aline Fréville, Ida Chiara Guerrera, Cerina Chhuon, Jean-Michel Saliou, Fabien Herbert, Christine Pierrot, Jamal Khalife
Publikováno v:
PLoS Pathogens, Vol 15, Iss 7, p e1007973 (2019)
The essential and distinct functions of Protein Phosphatase type 1 (PP1) catalytic subunit in eukaryotes are exclusively achieved through its interaction with a myriad of regulatory partners. In this work, we report the molecular and functional chara
Externí odkaz:
https://doaj.org/article/3039ee1299ea489092f6708cca2e5b2d
Autor:
Astrid Lenne, Caroline De Witte, Géraldine Tellier, Thomas Hollin, El Moukhtar Aliouat, Alain Martoriati, Katia Cailliau, Jean-Michel Saliou, Jamal Khalife, Christine Pierrot
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
With its multiple regulatory partners, the conserved Protein Phosphatase type-1 (PP1) plays a central role in many functions of the biology of eukaryotic cells, including Plasmodium falciparum. Here, we characterized a protein named PfRCC-PIP, as a m
Externí odkaz:
https://doaj.org/article/02723b2375b7440ebea155da67df12fe
Autor:
Audrey Vandomme, Aline Fréville, Katia Cailliau, Hadidjatou Kalamou, Jean-François Bodart, Jamal Khalife, Christine Pierrot
Publikováno v:
International Journal of Molecular Sciences, Vol 15, Iss 2, Pp 2431-2453 (2014)
In Plasmodium falciparum (Pf), the causative agent of the deadliest form of malaria, a tight regulation of phosphatase activity is crucial for the development of the parasite. In this study, we have identified and characterized PfPTPA homologous to P
Externí odkaz:
https://doaj.org/article/e083e65af494423ab2843cd4d285ae6d
Autor:
Alejandro Cabezas-Cruz, Miray Tonk, Anne Bouchut, Christine Pierrot, Raymond John Pierce, Michail Kotsyfakis, Mohammad Rahnamaeian, Andreas Vilcinskas, Jamal Khalife, James Jason Valdes
Publikováno v:
Frontiers in Microbiology, Vol 7 (2016)
Ancestral sequence reconstruction has been widely used to test evolution-based hypotheses. The genome of the European tick vector, Ixodes ricinus, encodes for defensin peptides with diverse antimicrobial activities against distantly related pathogens
Externí odkaz:
https://doaj.org/article/1555b98b114c48279b7a9f0a6f6e93e3
Autor:
Natalie Reimers, Arne Homann, Beate Höschler, Kristina Langhans, R Alan Wilson, Christine Pierrot, Jamal Khalife, Christoph G Grevelding, Iain W Chalmers, Maria Yazdanbakhsh, Karl F Hoffmann, Cornelis H Hokke, Helmut Haas, Gabriele Schramm
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003593 (2015)
BACKGROUND: Schistosomiasis is a serious health problem especially in developing countries and affects more than 243 million people. Only few anthelmintic drugs are available up to now. A major obstacle for drug treatment is the different development
Externí odkaz:
https://doaj.org/article/d6dad12c437e4550aed6ea0d973554d9
Autor:
Iain W Chalmers, Colin M Fitzsimmons, Martha Brown, Christine Pierrot, Frances M Jones, Jakub M Wawrzyniak, Narcis Fernandez-Fuentes, Edridah M Tukahebwa, David W Dunne, Jamal Khalife, Karl F Hoffmann
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 9, Iss 7, p e0003920 (2015)
The heptalaminate-covered, syncytial tegument is an important anatomical adaptation that enables schistosome parasites to maintain long-term, intravascular residence in definitive hosts. Investigation of the proteins present in this surface layer and
Externí odkaz:
https://doaj.org/article/056ec1d94ebd4525a82f6f65d1703c45