Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christine Pien"'
Autor:
Walid Kamoun, Elden Swindell, Christine Pien, Lia Luus, Jason Cain, Minh Pham, Irawati Kandela, Zhaohua Richard Huang, Suresh K. Tipparaju, Alexander Koshkaryev, Vasileios Askoxylakis, Dmitri B. Kirpotin, Troy Bloom, Mari Mino-Kenudson, James D. Marks, Alena Zalutskaya, Wiam Bshara, Carl Morrison, Daryl C. Drummond
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 996 (2020)
Ephrin receptor A2 (EphA2) is a member of the Ephrin/Eph receptor cell-to-cell signaling family of molecules, and it plays a key role in cell proliferation, differentiation, and migration. EphA2 is overexpressed in a broad range of cancers, and its e
Externí odkaz:
https://doaj.org/article/8d1191f930f84ed890aae26feb4148ee
Autor:
Lia Luus, Vasileios Askoxylakis, John Wilton, Alexey Lugovskoy, Kenneth J. Olivier, Stephanie Grabow, Jaeyeon Kim, Christine Pien, Geoffrey Kuesters, Suresh K. Tipparaju, Melissa Geddie, Nancy Dumont, Mark E. Hayes, Alexander Koshkaryev, Sarah A Schihl, C. Patrick Reynolds, Rachel Blaydes, Andrew J. Sawyer, James D. Marks, Tad Kornaga, James Suchy, Charles O. Noble, Dmitri B. Kirpotin, Shinji Oyama, Neeraj Kohli, Zhaohua Richard Huang, Walid S. Kamoun, Daryl C. Drummond, Yu Zhou
Publikováno v:
Nature Biomedical Engineering. 3:264-280
Antibody-mediated tumour targeting and nanoparticle-mediated encapsulation can reduce the toxicity of antitumour drugs and improve their efficacy. Here, we describe the performance of a nanotherapeutic encapsulating a hydrolytically sensitive docetax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d8e94f819de7e7f6ccdf49b01d0fee2
https://doi.org/10.1038/s41551-019-0385-4
https://doi.org/10.1038/s41551-019-0385-4
Autor:
Alexander Koshkaryev, Wiam Bshara, Jason E. Cain, Dmitri B. Kirpotin, Walid S. Kamoun, Elden P. Swindell, Troy Bloom, Daryl C. Drummond, Carl Morrison, Suresh K. Tipparaju, Zhaohua Richard Huang, Mari Mino-Kenudson, Minh T. Pham, Irawati Kandela, Vasileios Askoxylakis, Christine Pien, Alena Zalutskaya, Lia Luus, James D. Marks
Publikováno v:
Pharmaceutics, vol 12, iss 10
Pharmaceutics
Pharmaceutics, Vol 12, Iss 996, p 996 (2020)
Volume 12
Issue 10
Pharmaceutics
Pharmaceutics, Vol 12, Iss 996, p 996 (2020)
Volume 12
Issue 10
Ephrin receptor A2 (EphA2) is a member of the Ephrin/Eph receptor cell-to-cell signaling family of molecules, and it plays a key role in cell proliferation, differentiation, and migration. EphA2 is overexpressed in a broad range of cancers, and its e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d27d2b12f3a023adf89e3b13500e33
https://escholarship.org/uc/item/8b46q0tm
https://escholarship.org/uc/item/8b46q0tm
Autor:
Suresh K. Tipparaju, Charles O. Noble, Alexander Koshkaryev, Walid S. Kamoun, Jimmy Tran, Tad Kornaga, Daryl C. Drummond, Zhaohua Richard Huang, Christine Pien, Dmitri B. Kirpotin
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 310
Ephrin A2 targeted immunoliposomes incorporating pH-sensitive taxane prodrugs were developed for sustained delivery of active drug to solid tumors. Here we describe the systematic formulation development and characterization of these immunoliposomes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8518d6c9b5dbb65c54db1d72e289f2ed
https://pubmed.ncbi.nlm.nih.gov/31400383
https://pubmed.ncbi.nlm.nih.gov/31400383
Autor:
Charles A. Omer, Ken Thress, Lizhi Zeng, Patrick A. Zweidler Mckay, Peter E. Zage, Timothy Graham, Wendy Fang, Christine Pien, Jeffrey L. Brown
Publikováno v:
Cancer. 117(6)
BACKGROUND: TrkB expression is associated with poor prognosis for patients with neuroblastoma. AZ623 is a novel potent and selective inhibitor of the Trk family of tyrosine kinases. The authors hypothesized that AZ623 would inhibit TrkB-mediated sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a247c6aef3f9cc4ebaec85f401746f3e
https://pubmed.ncbi.nlm.nih.gov/20960503
https://pubmed.ncbi.nlm.nih.gov/20960503
Autor:
Joseph Pye, Julian Adams, Albert S. Baldwin, Dwight A. Bellinger, Timothy C. Nichols, Arlene S. McCain, Thomas Fischer, Peter J. Elliott, Christine Pien, Farhad Ardeshirpour, Elizabeth P. Merricks
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 284(3)
Both acute coronary occlusion and reperfusion of an infarct-related artery lead to significant myocardial cell death. Recent evidence has been presented that activation of the transcription factor nuclear factor-kappaB (NF-kappaB) plays a critical ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd00e0726328ee6eaed4e6b94fb1d235
https://pubmed.ncbi.nlm.nih.gov/12424098
https://pubmed.ncbi.nlm.nih.gov/12424098
Autor:
Thomas M. Zollner, Maurizio Podda, Christine Pien, Peter J. Elliott, Roland Kaufmann, Wolf-Henning Boehncke
Publikováno v:
Journal of Clinical Investigation, Vol. 109, No 5 (2002) pp. 671-679
There is increasing evidence that bacterial superantigens contribute to inflammation and T cell responses in psoriasis. Psoriatic inflammation entails a complex series of inductive and effector processes that require the regulated expression of vario
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d0da7dcc99253b2210cfb11add67f3
https://archive-ouverte.unige.ch/unige:29738
https://archive-ouverte.unige.ch/unige:29738
Autor:
Lizhi Zeng, Jeffrey L. Brown, Patrick A. Zweidler-McKay, Alejandro G. Levy, Riitta Nolo, Timothy C Graham, Wendy Fang, Sankaranarayanan Kannan, Maurizio L. Ghisoli, Christine Pien
Publikováno v:
Blood. 112:3789-3789
Background: TRKA (Tropomyosin Receptor Kinase A) is a member of the neurotrophin tyrosine kinase receptor family. Nerve Growth Factor (NGF) binds specifically to TRKA triggering multiple downstream pathways which regulate proliferation and differenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::033f1387f07b08811204036f86906bc8
https://doi.org/10.1182/blood.v112.11.3789.3789
https://doi.org/10.1182/blood.v112.11.3789.3789
Autor:
Vito Palombella, Corey C. Geer, Nikhil C. Munshi, John A. Barrett, Melissa Rooney, Jeffrey K. Tong, Teru Hideshima, Kenneth C. Anderson, Joseph Negri, Paul G. Richardson, Julian Brooklin Adams, Melissa Pink, Nicholas Mitsiades, David Grayzel, Constantine S. Mitsiades, Christine Pien, Dharminder Chauhan
Publikováno v:
Blood. 104:2403-2403
We have previously shown that inhibitors of the hsp90 molecular chaperone (including geldanamycin, 17-allylamino-17-demethoxy-geldanamycin (17-AAG) and other members of the ansamycin family) potently induce growth arrest and apoptosis of a large pane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3337693e6062953943278f87d37c58c8
https://doi.org/10.1182/blood.v104.11.2403.2403
https://doi.org/10.1182/blood.v104.11.2403.2403
Autor:
Jon Patterson, Vito J. Palombella, James H. Porter, David Grayzel, Asimina T. Georges, John P. Barrett, Christine Pien, Adams Julian, Jennie Ge, Jeffrey K. Tong, Kenneth C. Anderson, Kerry Spear, Roger H. Pak, Janid Ali, Jebecka Hudak, Constantine S. Mitsiades, Emmanuel Normant, James Homer Wright, Melissa Pink, Louis Grenier, Jens Sydor, Michael Foley, Yun Gao, Junbiao Sang
Publikováno v:
Blood. 104:4922-4922
IPI-504 is a novel inhibitor of Hsp90 based on the geldanamycin pharmacophore. When placed in rat, monkey, and human blood, IPI-504 rapidly converts to the known and well-studied compound 17-allylamino-17-demethoxy-geldanamycin (17-AAG). 17-AAG is th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd62aefb41f6324e4b5334429ce29775
https://doi.org/10.1182/blood.v104.11.4922.4922
https://doi.org/10.1182/blood.v104.11.4922.4922