Výsledky vyhledávání - "Christine Petzoldt"

An example of how to handle amorphous fractions in API during early pharmaceutical development: SAR114137--a successful approach

Autor: Martin Feth, Bruno Baumgartner, Doris Andert, Stephen Byard, Norbert Nagel, Oliver Bley, Christoph Tappertzhofen, Christine Petzoldt

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 86(3)

The so-called pharmaceutical solid chain, which encompasses drug substance micronisation to the final tablet production, at pilot plant scale is presented as a case study for a novel, highly potent, pharmaceutical compound: SAR114137. Various solid-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4092ae2af1957f6ebc52088307e41a
https://pubmed.ncbi.nlm.nih.gov/24075979

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From laboratory to pilot plant: the solid-state process development of a highly potent cathepsin S/K inhibitor

Autor: Jörg Jurascheck, Christine Petzoldt, Thomas Olpp, Lydia Helmdach, Bruno Baumgartner, Martin P. Feth, Joachim Ulrich, Christoph Tappertzhofen, Norbert Nagel, Winfried Heyse

Publikováno v: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 83(3)

The solid-state development for the low dose drug molecule SAR114137, a selective and reversible inhibitor of cysteine cathepsin S/K, is reported. Six polymorphic forms as well as various solvate phases were discovered by an extensive polymorphism sc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f777b985a3fb2be27a370a88712370f6
https://pubmed.ncbi.nlm.nih.gov/23201054

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