Výsledky vyhledávání - "Christine Petzel"

HEMA-induced oxidative stress inhibits NF-κB nuclear translocation and TNF release from LTA- and LPS-stimulated immunocompetent cells

Autor: Claudia Waha, Christine Petzel, Wolfgang Buchalla, Helmut Schweikl, Carola Bolay, Marialucia Gallorini, Margaritha Birke, Karl-Anton Hiller

Publikováno v: Dental Materials. 37:175-190

Objective: The release of inflammatory cytokines from antigen-stimulated cells of the immune system is inhibited by resin monomers such as 2-hydroxyethyl methacrylate (HEMA). Although the formation of oxidative stress in cells exposed to HEMA is firm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a5f2d954fbee2b2cea0e2895274f92f
https://doi.org/10.1016/j.dental.2020.10.029

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Flavin-containing enzymes as a source of reactive oxygen species in HEMA-induced apoptosis

Autor: Markus Forstner, Helmut Schweikl, Christine Petzel, Karl-Anton Hiller, Wolfgang Buchalla, Stephanie Krifka, Carola Bolay, Marialucia Gallorini, Amelia Cataldi

Publikováno v: Dental Materials. 33:e255-e271

Objective Oxidative stress induced by compounds of dental composites like 2-hydroxyethyl methacrylate (HEMA) due to excess formation of reactive oxygen species (ROS) disturbs vital cell functions leading to apoptosis. The sources of ROS in cells expo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2cdb97b6db7a408aeb97fe37bc70f6
https://doi.org/10.1016/j.dental.2017.01.014

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Critical role of superoxide anions and hydroxyl radicals in HEMA-induced apoptosis

Autor: Carola Bolay, Christine Petzel, Helmut Schweikl, K-A Hiller, M. Godula, Wolfgang Buchalla

Publikováno v: Dental Materials. 33:110-118

Objective Resin monomers such as 2-hydroxyethyl methacrylate (HEMA) induce apoptosis because of the excess formation of reactive oxygen species (ROS). The portion of ROS including superoxide anions, hydrogen peroxide or hydroxyl radicals in monomer-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::491a6c64b83dbf86e95fc51fe5120067
https://doi.org/10.1016/j.dental.2016.11.003

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Functions of transcription factors NF-κB and Nrf2 in the inhibition of LPS-stimulated cytokine release by the resin monomer HEMA

Autor: Vera Urmann, Christine Petzel, Karl-Anton Hiller, Gerd Pöschl, Amelia Cataldi, Helmut Schweikl, Wolfgang Buchalla, Carola Bolay, Marialucia Gallorini

Publikováno v: Dental materials : official publication of the Academy of Dental Materials. 34(11)

Objective Resin monomers like 2-hydroxyethyl methacrylate (HEMA) interfere with effects induced by stressors such as lipopolysaccharide (LPS) released from cariogenic microorganisms. In this study, mechanisms underlying monomer-induced inhibition of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9158c432f9c3e216232ae7fc178bfd9f
https://pubmed.ncbi.nlm.nih.gov/30196988

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Resin monomer-induced differential activation of MAP kinases and apoptosis in mouse macrophages and human pulp cells

Autor: Gottfried Schmalz, Christine Petzel, Claudi A. Bosl, Gianrico Spagnuolo, Eva-Maria Frank, Karl-Anton Hiller, Helmut Schweikl, Franz-Xaver Reichl, Stephanie Krifka

Publikováno v: Biomaterials. 31:2964-2975

Triethylene glycol dimethacrylate (TEGDMA) is a resin monomer which is released from polymerized dental composite materials. It induced apoptosis in various target cells or inhibition of LPS-induced cytokine production in cells of the immune system a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925239bf192beb6cd1af83d5ae990dfd
https://doi.org/10.1016/j.biomaterials.2010.01.005

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Interaction between LPS and a dental resin monomer on cell viability in mouse macrophages

Autor: Wolfgang Buchalla, Stephanie Krifka, Karl-Anton Hiller, Christine Petzel, Helmut Schweikl, Johannes Klement, Matthias Widbiller, Carola Bolay

Publikováno v: Dental materials : official publication of the Academy of Dental Materials. 32(12)

Objective Lipopolysaccharide (LPS) from cariogenic microorganisms and resin monomers like HEMA (2-hydroxyethyl methacrylate) included in dentin adhesive are present in a clinical situation in deep dentinal cavity preparations. Here, cell survival, ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36543d7a4523b8a4389ca29ef6ebd600
https://pubmed.ncbi.nlm.nih.gov/27671463

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Activation of the Nrf2-regulated antioxidant cell response inhibits HEMA-induced oxidative stress and supports cell viability

Autor: Helmut Schweikl, Amelia Cataldi, Wolfgang Buchalla, Carola Bolay, Christine Petzel, Stephanie Krifka, Karl-Anton Hiller, Marialucia Gallorini

Publikováno v: Biomaterials. 56

Oxidative stress due to increased formation of reactive oxygen species (ROS) in target cells of dental resin monomers like 2-hydroxyethyl methacrylate (HEMA) is a major mechanism underlying the disturbance of vital cell functions including mineraliza

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7562d879038e2e01b1dcffadaf157ea9
https://pubmed.ncbi.nlm.nih.gov/25934285

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2-Hydroxyethyl methacrylate-induced apoptosis through the ATM- and p53-dependent intrinsic mitochondrial pathway

Autor: Stephanie Krifka, Helmut Schweikl, Carola Bolay, Wolfgang Buchalla, Christine Petzel, Karl-Anton Hiller

Publikováno v: Biomaterials. 35(9)

Resin monomers of dental composites like 2-hydroxyethyl methacrylate (HEMA) disturb cell functions including responses of the innate immune system, mineralization and differentiation of dental pulp-derived cells, or induce cell death via apoptosis. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55db3a77c2202a1528c67c9bd7940270
https://pubmed.ncbi.nlm.nih.gov/24411679

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Function of MAPK and downstream transcription factors in monomer-induced apoptosis

Autor: Gottfried Schmalz, Carola Bolay, Helmut Schweikl, Karl-Anton Hiller, Franz-Xaver Reichl, Gianrico Spagnuolo, Stephanie Krifka, Christine Petzel

The resin monomer triethylene glycol dimethacrylate (TEGDMA) disrupts vital cell functions, and the production of oxidative stress is considered a common underlying mechanism. The precise signaling pathways, however, that initiate monomer-induced eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b1f262d916473ab7945c11501b70ba0
http://hdl.handle.net/11588/472279

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Activation of stress-regulated transcription factors by triethylene glycol dimethacrylate monomer

Autor: Gottfried Schmalz, Gianrico Spagnuolo, Helmut Schweikl, Stephanie Krifka, Carola Bolay, Karl-Anton Hiller, Christine Petzel

Publikováno v: Biomaterials. 32(7)

Triethylene glycol dimethacrylate (TEGDMA) is a resin monomer available for short exposure scenarios of oral tissues due to incomplete polymerization processes of dental composite materials. The generation of reactive oxygen species (ROS) in the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31782846cefbd1fb61be1158641b5d1
https://pubmed.ncbi.nlm.nih.gov/21145583

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