5-HIAA induces neprilysin to ameliorate pathophysiology and symptoms in a mouse model for Alzheimer’s disease

Autor: Christian Klein, Guy Roussel, Susana Brun, Cristina Rusu, Christine Patte-Mensah, Michel Maitre, Ayikoe-Guy Mensah-Nyagan

Publikováno v: Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)

Abstract Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer’s disease (AD), but the mechanisms involved remain unclear. Because growing evidence suggested that the stimulation of prot

Externí odkaz: https://doaj.org/article/6b1440d4880b423c9621aa30a13480e7

The biological activity of 3α-hydroxysteroid oxido-reductase in the spinal cord regulates thermal and mechanical pain thresholds after sciatic nerve injury

Autor: Laurence Meyer, Christine Venard, Véronique Schaeffer, Christine Patte-Mensah, Ayikoe G. Mensah-Nyagan

Publikováno v: Neurobiology of Disease, Vol 30, Iss 1, Pp 30-41 (2008)

Identification of cellular targets pertinent for the development of effective therapies against pathological pain constitutes a difficult challenge. We combined several approaches to show that 3α-hydroxysteroid oxido-reductase (3α-HSOR), abundantly

Externí odkaz: https://doaj.org/article/5365de7ffa9c40399e4a12203f298c8d

A Narrative Review on Axonal Neuroprotection in Multiple Sclerosis

Autor: Nicolas Collongues, Guillaume Becker, Valérie Jolivel, Estelle Ayme-Dietrich, Jérôme de Seze, Fabien Binamé, Christine Patte-Mensah, Laurent Monassier, Ayikoé Guy Mensah-Nyagan

Publikováno v: Neurology and Therapy. 11:981-1042

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) resulting in demyelination and neurodegeneration. The therapeutic strategy is now largely based on reducing inflammation with immunosuppressive drugs. Unfor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::173f6e906325fda6474cb6ce55b93e1a
https://doi.org/10.1007/s40120-022-00363-7

Novel Use of Home Pulse Oximetry Monitoring in COVID‐19 Patients Discharged From the Emergency Department Identifies Need for Hospitalization

Autor: Joseph Capannari, Nita Gupta, Kaushal Majmudar, Christine Patte, Spencer Suppes, Marina Karamanis, Sanjay Sethi, Amy L. Stein, Sonia Shah

Publikováno v: Academic Emergency Medicine

OBJECTIVES: Our objective was to evaluate patient-reported oxygen saturation (SpO2 ) using pulse oximetry as a home monitoring tool for patients with initially nonsevere COVID-19 to identify need for hospitalization. METHODS: Patients were enrolled a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::942f01e6a598a5094214112915ae8332
https://doi.org/10.1111/acem.14053

Rapid Discrimination of Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis Using Machine Learning on Infrared Spectra of Sera

Autor: Youssef El Khoury, Marie Gebelin, Jérôme de Sèze, Christine Patte-Mensah, Gilles Marcou, Alexandre Varnek, Ayikoé-Guy Mensah-Nyagan, Petra Hellwig, Nicolas Collongues

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, 2022, 23 (5), pp.2791. ⟨10.3390/ijms23052791⟩
International Journal of Molecular Sciences; Volume 23; Issue 5; Pages: 2791

International audience; Neuromyelitis optica spectrum disorder (NMOSD) and multiple sclerosis (MS) are both autoimmune inflammatory and demyelinating diseases of the central nervous system. NMOSD is a highly disabling disease and rapid introduction o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec52a06af282c039a97dab835845be9
https://doi.org/10.3390/ijms23052791