Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christine P. Parker"'
Autor:
Marta Vicente-Rodríguez, Renzo Mancuso, Alba Peris-Yague, Camilla Simmons, NIMA Consortium, Diego Gómez-Nicola, V. Hugh Perry, Federico Turkheimer, Simon Lovestone, Christine A. Parker, Diana Cash
Publikováno v:
Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Neuroinflammation is an important component of many neurodegenerative diseases, whether as a primary cause or a secondary outcome. For that reason, either as diagnostic tools or to monitor progression and/or pharmacological interventions, th
Externí odkaz:
https://doaj.org/article/b170cf7515074d439babacd3d3763def
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 9787 (2023)
Targeting neuroinflammation, and in particular, microglial activation and astrocytosis, is a current area of the focus of new treatment interventions for a number of neurodegenerative disorders. Probing the roles of microglia and astrocytes in human
Externí odkaz:
https://doaj.org/article/17c1868452db4846ae91abf61f341fcd
Autor:
Ashwin V. Venkataraman, Nicholas Keat, James F. Myers, Samuel Turton, Inge Mick, Roger N. Gunn, Eugenii A. Rabiner, Jan Passchier, Christine A. Parker, Robin J. Tyacke, David J. Nutt
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-7 (2018)
Abstract Background We measured whole body distribution of 11C-BU99008, a new PET biomarker for non-invasive identification of the imidazoline2 binding site. The purpose of this phase I study was to evaluate the biodistribution and radiation dosimetr
Externí odkaz:
https://doaj.org/article/0063b94551df472fbb9998d94ab821a5
Publikováno v:
Applied Sciences, Vol 11, Iss 9, p 4264 (2021)
Identification of bacteria by mass spectrometry offers the potential of a high-throughput non-targeted method to determine the presence of Salmonella. While MALDI-TOF mass spectrometry can identify Salmonella at the genus and species level, few studi
Externí odkaz:
https://doaj.org/article/625b5941f4bb4c06930af596b34790fe
Autor:
Cary Pirone-Davies, Melinda A. McFarland, Christine H. Parker, Yoko Adachi, Timothy R. Croley
Publikováno v:
Biology, Vol 9, Iss 5, p 104 (2020)
As the apparent incidence of tree nut allergies rises, the development of MS methods that accurately identify tree nuts in food is critical. However, analyses are limited by few available tree nut protein sequences. We assess the utility of translate
Externí odkaz:
https://doaj.org/article/cb51da68b20a47dc84e240da23e2629b
Autor:
David W. Marsan, Stephen M. Conrad, Whitney L. Stutts, Christine H. Parker, Jonathan R. Deeds
Publikováno v:
Heliyon, Vol 4, Iss 3, Pp e00573- (2018)
The cyanobacterium Aphanizomenon flos-aquae (AFA), from Upper-Klamath Lake, Oregon, are used to produce blue-green algal (BGA) dietary supplements. The periodic co-occurrence of hepatotoxin-producing contaminant species prompted the Oregon Health Div
Externí odkaz:
https://doaj.org/article/04f3473f32a24ea98d4059795a3e2245
Autor:
Timothy A. Subashi, Douglas S. Johnson, Christine E. Oborski, Kevin Atchison, Kathleen M. Wood, Christine P. Parker, Rathna Iyer, Bruce A. Maguire, Martin Pettersson, Kelly R. Bales, Nikolay Pozdnyakov, Gary Bora
Publikováno v:
Neuroscience and Medicine. :149-161
γ-Secretase is involved in the final processing of the amyloid precursor protein into a heterogeneous pool of β-amyloid (Aβ) peptides. Current Alzheimer’s disease drug discovery efforts include targeting γ-secretase activity in brain to attenua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60af06540d662be62708d6c734dd860c
https://doi.org/10.4236/nm.2012.32020
https://doi.org/10.4236/nm.2012.32020
Autor:
Douglas E. Wood, Robert B. Nelson, Barbara G. Sahagan, Xingrong Liu, Lei Zhang, Nikolay Pozdnyakov, Jeffrey Van Deusen, Karl E.G. Richter, James E. Finley, Christine P. Parker, Karen J. Coffman, Michael Aaron Brodney, Barbara-Anne Martin, David D. Auperin, Joel B. Schachter, Dane R. Liston, Michael J. Karmilowicz, Tracy M. Brown, Barbara Tate, Christine E. Oborski, Sharon A. Sokolowski, Stacey L. Becker, Bronk Brian Scott, Thomas A. Lanz, Carol D. Hicks, Charles E. Nolan, Kathleen M. Wood
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2637-2640
A novel series of tetralin containing amino imidazoles, derived from modification of the corresponding phenyl acetic acid derivatives is described. Replacement of the amide led to identification of a potent series of tetralin-amino imidazoles with ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecedc3d6dd0ae90f3f64245736a002bc
https://doi.org/10.1016/j.bmcl.2010.12.118
https://doi.org/10.1016/j.bmcl.2010.12.118
Autor:
Nikolay Pozdnyakov, Karen J. Coffman, Bronk Brian Scott, Douglas E. Wood, Xingrong Liu, Karl E.G. Richter, Dane R. Liston, James E. Finley, Sharon A. Sokolowski, Barbara Tate, Thomas A. Lanz, Michael Aaron Brodney, Christine E. Oborski, Jeffrey Van Deusen, Stacey L. Becker, Carol D. Hicks, Charles E. Nolan, Kathleen M. Wood, Michael J. Karmilowicz, Barbara-Anne Martin, Joel B. Schachter, Christine P. Parker, Robert B. Nelson, David D. Auperin, Barbara G. Sahagan, Tracy M. Brown
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(9)
The synthesis and structure–activity relationship (SAR) of a novel series of di-substituted imidazoles, derived from modification of DAPT, are described. Subsequent optimization led to identification of a highly potent series of inhibitors that con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5ef01d39846e8c2950263ae44f3e4b
https://pubmed.ncbi.nlm.nih.gov/21269825
https://pubmed.ncbi.nlm.nih.gov/21269825
Autor:
Kelly R. Bales, Douglas S. Johnson, Martin Pettersson, Rathna Iyer, Christine P. Parker, Christine E. Oborski
Publikováno v:
Alzheimer's & Dementia. 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e79ecfb01901889c2b43ab942f12893a
https://doi.org/10.1016/j.jalz.2010.05.848
https://doi.org/10.1016/j.jalz.2010.05.848