Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Christine P. Donahue"'
Autor:
Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and anti
Externí odkaz:
https://doaj.org/article/a0c4424f2eeb46a689586e4828ae7887
Autor:
Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 8: Article number: 16081 (2017); Published: 17 July 2017, Updated: 13 July 2018 The original version of this Article omitted the following from the Acknowledgements: ‘We thank Robert Kirkpatrick for implementing the high throu
Externí odkaz:
https://doaj.org/article/ee8d0f7b2ad14f48b638c180d558c296
Autor:
Ankit Chhoda, Anup Sharma, Bethsebie Sailo, Haoyu Tang, Nensi Ruzgar, Wan Ying Tan, Lee Ying, Rishabh Khatri, Anand Narayanan, Shrikant Mane, Bony De Kumar, Laura D. Wood, Christine Iacobuzio-Donahue, Christopher L. Wolfgang, John W. Kunstman, Ronald R. Salem, James J. Farrell, Nita Ahuja
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-8 (2023)
Abstract Background Intraductal papillary mucinous neoplasms (IPMNs), a type of cystic pancreatic cancer (PC) precursors, are increasingly identified on cross-sectional imaging and present a significant diagnostic challenge. While surgical resection
Externí odkaz:
https://doaj.org/article/546ba8af962b49deaa4afd35f88e5578
Autor:
Yang Liu, Suxin Zheng, Eleanor Peacey, Christine P. Donahue, Michael S. Wolfe, Gabriele Varani, John R. Dickson
Publikováno v:
Journal of Medicinal Chemistry. 52:6523-6526
A series of mitoxantrone (MTX) analogues have been designed, synthesized, and evaluated for binding to and stabilizing a stem-loop structure that serves as a splicing regulatory element in the pre-mRNA of tau, which is involved in Alzheimer's and oth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185c0ec7a016ac6742cefe72f3c09d40
https://doi.org/10.1021/jm9013407
https://doi.org/10.1021/jm9013407
Publikováno v:
SLAS Discovery. 12:789-799
Alternative splicing of tau exon 10 produces tau isoforms with either 3 (3R) or 4 (4R) repeated microtubule-binding domains. Increased ratios of 4R to 3R tau expression, above the physiological 1:1, leads to neurofibrillary tangles and causes neurode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb267f0a137b7182add02e135b621296
https://doi.org/10.1177/1087057107302676
https://doi.org/10.1177/1087057107302676
Publikováno v:
Journal of Biological Chemistry. 281:23302-23306
Neurofibrillary tangles containing filaments of the microtubule-associated protein tau are found in a variety of neurodegenerative diseases. Mutations in the tau gene itself cause frontotemporal dementia with parkinsonism, demonstrating the critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff17be064c06ba87594d239af56c936b
https://doi.org/10.1074/jbc.c600143200
https://doi.org/10.1074/jbc.c600143200
Publikováno v:
Proceedings of the National Academy of Sciences. 103:6031-6036
Recent studies by our group and others have demonstrated that growth hormone (GH) is produced endogenously within the hippocampal formation, a brain structure associated with learning and aspects of emotional experience. Here, we demonstrate that thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9820a65c463a1fcff5d0df8dbceaed85
https://doi.org/10.1073/pnas.0507776103
https://doi.org/10.1073/pnas.0507776103
Autor:
Erik Fung, Peter Libby, Min Liu, Masanori Aikawa, Diane C. Darland, Patricia A. D'Amore, Raajit Rampal, Robert S. Haltiwanger, Christine P. Donahue, Maria Cruz Martinez, Manuel F. Navarro-Gonzalez, Joseph F. Arboleda-Velasquez, Kenneth S. Kosik
Publikováno v:
Human Molecular Genetics. 14:1631-1639
Mutations in the NOTCH3 gene trigger adult-onset stroke and vascular dementia in patients with CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). All CADASIL mutations described to date affect the ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386d403ea4682a33238ffb04828c5e00
https://doi.org/10.1093/hmg/ddi171
https://doi.org/10.1093/hmg/ddi171
Publikováno v:
Trends in Cell Biology. 15:172-178
δ-catenin belongs to the p120-catenin (p120 ctn ) protein family, which is characterized by ten, characteristically spaced Armadillo repeats that bind to the juxtamembrane segment of the classical cadherins. δ-catenin is the only member of this fam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c7242e9ba16177b41ae866ceb0278c1
https://doi.org/10.1016/j.tcb.2005.01.004
https://doi.org/10.1016/j.tcb.2005.01.004
Autor:
Christine P. Donahue, Kenneth S. Kosik
Publikováno v:
Genomics. 83:59-65
Mutations in Notch3 cause the syndrome CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). The mechanism by which these mutations result in a CADASIL phenotype has been widely speculated upon. A first
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e38e044f39e8021032b4f4c52ce49bda
https://doi.org/10.1016/s0888-7543(03)00206-4
https://doi.org/10.1016/s0888-7543(03)00206-4