Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christine P, Bono"'
Autor:
Christine P. Bono, Mazin Derzi, Lindsay Tomlinson, Bart Jessen, Anna K. Kopec, James E. Finley, Ikuo Horii, John E. Burkhardt, Shuyan Lu, Carol B. Donovan, Julie Harney, Mark Collinge, Andrew D. Burdick, Ryuji Yokokawa, Ramin Banan Sadeghian, Nasir K. Khan, Jessica Roy
Publikováno v:
The Journal of toxicological sciences. 46(3)
Microphysiological systems (MPS) are making advances to provide more standardized and predictive physiologically relevant responses to test articles in living tissues and organ systems. The excitement surrounding the potential of MPS to better predic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f9e5347e752a79f1985fa87509e7116
https://pubmed.ncbi.nlm.nih.gov/33642521
https://pubmed.ncbi.nlm.nih.gov/33642521
Publikováno v:
Cytometry Part B: Clinical Cytometry. 90:191-198
Background Interleukin-7 receptor α (IL-7Rα) is associated with autoimmune disease. Blocking its activation by interleukin-7 (IL-7) with a therapeutic monoclonal antibody may reduce pathogenic T cells and effectively control the autoimmune response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f198cf4b3e89524f037a561ca0b7124c
https://doi.org/10.1002/cyto.b.21247
https://doi.org/10.1002/cyto.b.21247
Autor:
Barbara A. Schweitzer, Atli Thorarensen, Michael S. Davies, Steve R. Turner, Matthew James Pelc, James R. Kiefer, Brenda L. Case, Christie L. Funckes-Shippy, Jacqueline E. Day, Fengmei Hua, Dice Tom, William M. Abraham, Bradley E. Neal, John I. Trujillo, Joseph B. Moon, Blake Tanisha Danielle Rowe, Wei Huang, Craig D. Wegner, Dean Welsch, Chris P. Carron, Anup Zutshi, Bruce C. Hamper, Chad J. Warren, Rhonda S. Woerndle, Christine M. Kornmeier, Vickie M. Dilworth, Melanie L. Williams, Martin E. Dowty, Olson Kirk Lang, Melissa R. Radabaugh, Becky L. Hood, Jerry Z. Yang, Douglas C. Rohrer, Gina M. Jerome, Christine P. Bono
Publikováno v:
ACS Medicinal Chemistry Letters. 1:59-63
Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH2 into PGD2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6559b7ee90a239bc2255e65f4dd700
https://doi.org/10.1021/ml900025z
https://doi.org/10.1021/ml900025z
Autor:
Gunnar J. Hanson, Susan C. Howard, Michelle L. Zacheis, Christine P. Bono, Joseph K. Welply, Jennifer L. Vuletich, Louis J. Bedell, Neena L. Summers, Benjamin D. Schwartz, Susan L. Woulfe
Publikováno v:
Protein & Peptide Letters. 4:63-68
Abstract: We have synthesized a series of retro-inverso D-peptide analogues and a peptoid analog that mimic potent seven residue L-peptide ligands for DR(a. Pl*0401). The L-peptide ligands compete against binding of a 13 residue biotinylated ligand,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d5f3c4dae482c55fa4d7938953ea4b
https://doi.org/10.2174/092986650401221012144617
https://doi.org/10.2174/092986650401221012144617
Autor:
Susan L. Woulfe, Michelle L. Zacheis, Jennifer L. Vuletich, Louis J. Bedell, Christine P. Bono, Susan C. Howard, Joseph K. Welply, Gunnar J. Hanson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1931-1936
High potency synthetic ligands were designed for rheumatoid arthritis linked Class II MHC, DR4 Dw4. The design strategy utilized isosteric replacements at the p1 and p7 positions and conformational restriction with imino acids pipecolic acid (Pec) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::829a6226851b82e92bf820b086ea583f
https://doi.org/10.1016/0960-894x(96)00348-4
https://doi.org/10.1016/0960-894x(96)00348-4
Autor:
Robert W. Karr, Christine P. Bono, D.A. Kirschmann, Michelle L. Zacheis, Benjamin D. Schwartz, Troy A. Baudino, Craig Swearingen, Susan L. Woulfe
Publikováno v:
Arthritis & Rheumatism. 38:1744-1753
Objective. To identify critical residues involved in the binding of a selective peptide to DRB1*0401. Methods. The binding of peptides to native or site-directed mutant DR molecules was evaluated using enzyme-linked immunosorbent assay and flow cytom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b526af1d513e5c53e9ab9c2614de2ae8
https://doi.org/10.1002/art.1780381207
https://doi.org/10.1002/art.1780381207
Autor:
Cyrille Kuhn, James R. Kiefer, Christine M. Kornmeier, Joseph B. Moon, John I. Trujillo, Wei Huang, Christine P. Bono, Melanie L. Williams, Gina M. Jerome, Christopher P. Carron, Atli Thorarensen, Jacqueline E. Day, Glen Rennie, Thomas A. Wynn
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(11)
The inhibition of hH-PGDS has been proposed as a potential target for the development of anti-allergic and anti-inflammatory drugs. Herein we describe our investigation of the binding pocket of this important enzyme and our observation that two water
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6318bd90e1b5637c1aac619d04c64413
https://pubmed.ncbi.nlm.nih.gov/22546671
https://pubmed.ncbi.nlm.nih.gov/22546671
Autor:
Wen-Rong Lie, Pegg Jodi Ann, J. Alan Arbuckle, John Elvin, Mark Moffat, Tristan J. Vaughan, Simon N Lennard, Debra M. Meyer, Duo Sun, Michelle L. Evans, Christine E. Smith, Peter J. Nicastro, Gerald Fries Casperson, Karen S. Bailey, Phillip A. Morton, Herbert A. Runnels, Christine P. Bono
Publikováno v:
Advances in therapy. 27(7)
The insulin-like growth factor type 1 (IGF-1) receptor contributes importantly to transformation and survival of tumor cells both in vitro and in vivo, and selective antagonists of the IGF-1 receptor (IGF-1R) activity represent an attractive experime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e443f78e59c96d3ef899939efb4ac2
https://pubmed.ncbi.nlm.nih.gov/20574692
https://pubmed.ncbi.nlm.nih.gov/20574692
Autor:
Larry E, Kahn, Parul D, Doshi, Kelly L, McGarity, Mingfu, Yu, Christine P, Bono, Wen-Rong, Lie, Anne M, Rankin, Mary L, Smidt, Philip R, Streeter, Barbara K, Klein, Joseph K, Welply, Susan L, Woulfe
Publikováno v:
Medical science monitor : international medical journal of experimental and clinical research. 8(12)
Progenipoietin-4 (ProGP-4) is an E. coli derived chimeric growth factor that activates the human Flt3 and G-CSF receptors. ProGP-4 possesses cross-species activity and treatment of mice with ProGP-4 results in increases in the number of WBC and Class
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1205903f8d184d7782765295c60a228c
https://pubmed.ncbi.nlm.nih.gov/12503028
https://pubmed.ncbi.nlm.nih.gov/12503028
Autor:
Daniel L. Dexter, Karen S. Bailey, Beth A. Hollister, Deborah L. Knoerzer, Sudhir Agrawal, Shih-Fong Chen, Terri L. Alford, Brenda Hill, Ekambar R. Kandimalla, Phillip A. Morton, Dong Yu, Christine P. Bono
Publikováno v:
International journal of oncology. 18(5)
Co-administration of synthetic chemically modified oligonucleotides with irinotecan, a selective topoisomerase I inhibitor, provided a significant enhancement in the antitumor activity of irinotecan. The enhancement of antitumor activity of irinoteca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70ab09e2e00ff39eace0967e4972c848
https://pubmed.ncbi.nlm.nih.gov/11295057
https://pubmed.ncbi.nlm.nih.gov/11295057