Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Christine Nicole S. Santos"'
Publikováno v:
Current Opinion in Biotechnology. 69:iii-v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::558c0592ac7a76e0d968e5a2614aac57
https://doi.org/10.1016/j.copbio.2021.06.006
https://doi.org/10.1016/j.copbio.2021.06.006
Autor:
Vikas Patil, Christine Nicole S. Santos, Stephen Sarria, Parayil Kumaran Ajikumar, Ralf Takors
Publikováno v:
Biotechnology and bioengineeringREFERENCES. 118(3)
Amorpha-4,11-diene (AMD4,11) is a precursor to artemisinin, a potent antimalarial drug that is traditionally extracted from the shrubs of Artemisia annua. Despite significant prior efforts to produce artemisinin and its precursors through biotechnolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7635cf034835498e4502ce9dbc239b
https://pubmed.ncbi.nlm.nih.gov/33331668
https://pubmed.ncbi.nlm.nih.gov/33331668
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1927
The goal of strain optimization is to create high-performance strains producing compounds of interest at a high titer, yield, and volumetric productivity. The effectiveness of strain optimization relies on methodologies used to aid optimization of na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cfc733bf312e56d7e401f4b140ae201f
https://pubmed.ncbi.nlm.nih.gov/30788793
https://pubmed.ncbi.nlm.nih.gov/30788793
Publikováno v:
Nature Protocols. 9:1320-1336
Here we describe an advanced paradigm for the design, construction and stable implementation of complex biological systems in microbial organisms. This engineering strategy was previously applied to the development of an Escherichia coli-based platfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df060c44b71e326ce9f7f402cf671ca
https://doi.org/10.1038/nprot.2014.084
https://doi.org/10.1038/nprot.2014.084
Autor:
Yasuo Yoshikuni, Paul Daniel Donohoue, Dennis J. Miller, Preethi Sarvabhowman, Nicholas L. Ohler, Christine Nicole S. Santos, Maria Enquist-Newman, Ryan M. Raisner, Susan Rudd Cooper, Vineet Rajgarhia, Shital A. Tripathi, Carlos J. Paredes, Edward J. Kim, Lily Luo, Brigit E. Lamberson, Ann Marie E. Faust, Richard B. Bailey, Alana Clark, Hans Kristian Kotlar, Yessica Martinez, Padma Karamchedu, Avinash Gill, Pramila Tamrakar, Arthur Hanel, Joshua Goldsmith, Jeffrey Louis Villari, Candace Swimmer, Daniel D. Bravo, Drew D. Regitsky, Lars Peereboom, Chi Le, Min Y. Cho
Publikováno v:
Nature. 505:239-243
Saccharomyces cerevisiae bearing engineered alginate and mannitol catabolic pathways can ferment sugars from brown macroalgae to produce ethanol, potentially allowing the use of brown macroalgae as a viable feedstock for the production of biofuels an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f950a32fb1768442530572ed895348f
https://doi.org/10.1038/nature12771
https://doi.org/10.1038/nature12771
Publikováno v:
Proceedings of the National Academy of Sciences. 109:13538-13543
Although microbial metabolic engineering has traditionally relied on rational and knowledge-driven techniques, significant improvements in strain performance can be further obtained through the use of combinatorial approaches exploiting phenotypic di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a01dfcc0889baa6f8e67fcfdeea195d
https://doi.org/10.1073/pnas.1206346109
https://doi.org/10.1073/pnas.1206346109
Autor:
Yasuo Yoshikuni, David Baker, Ryan M. Raisner, Asael Herman, Yuki Kashiyama, Effendi Leonard, Maung Nyan Win, Alicia B. Sivitz, Peter B Kim, Christine Nicole S. Santos, Drew D. Regitsky, Susan Rudd Cooper, Arun Lakshmanaswamy, Adam J. Wargacki
Publikováno v:
Science. 335:308-313
Prospecting macroalgae (seaweeds) as feedstocks for bioconversion into biofuels and commodity chemical compounds is limited primarily by the availability of tractable microorganisms that can metabolize alginate polysaccharides. Here, we present the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e53c7e3d80826dd1e9a9c411441ba1f
https://doi.org/10.1126/science.1214547
https://doi.org/10.1126/science.1214547
Publikováno v:
Applied and Environmental Microbiology. 75:2705-2711
Combinatorial or random methods for strain engineering have been extensively used for the improvement of multigenic phenotypes and other traits for which the underlying mechanism is not fully understood. Although the preferred method has traditionall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b43beea1a7bac2e4da6e855acefe693f
https://doi.org/10.1128/aem.01888-08
https://doi.org/10.1128/aem.01888-08
Publikováno v:
Current Opinion in Chemical Biology. 12:168-176
Although random mutagenesis and screening and evolutionary engineering have long been the gold standards for strain improvement in industry, the development of more sophisticated recombinant DNA tools has led to the introduction of alternate methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bc91b020f29ae5426ef643a7ce26b73
https://doi.org/10.1016/j.cbpa.2008.01.017
https://doi.org/10.1016/j.cbpa.2008.01.017
Autor:
Brecht De Paepe, Parayil Kumaran Ajikumar, Marjan De Mey, Christine Nicole S. Santos, Bradley W. Biggs
Publikováno v:
Current opinion in biotechnology. 29
Despite the potential in utilizing microbial fermentation for chemical production, the field of industrial biotechnology still lacks a standard, universally applicable principle for strain optimization. A key challenge has been in finding and applyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61acb2f9d5303db02750d0e34266db5a
https://pubmed.ncbi.nlm.nih.gov/24927371
https://pubmed.ncbi.nlm.nih.gov/24927371