Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christine N. Hinko"'
Autor:
Jonathan R. Dimmock, Christine N. Hinko, Puthucode Ramanan Narayan, James P. Stables, Glen B. Baker, John M. Tuchek, Caren L. Steinmiller
Publikováno v:
Drug Development Research. 46:112-125
A series of aryloxyaryl semicarbazones had been shown previously to possess significant anticonvulsant activity in the maximal electroshock screen in both rats and mice as well as in the subcutaneous pentylenetetrazol test in mice. One member of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27a5fc9201eeb375bc4a589cfd75bfcd
https://doi.org/10.1002/(sici)1098-2299(199902)46:2<112::aid-ddr4>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199902)46:2<112::aid-ddr4>3.0.co
Autor:
David S. Roane, Bin Ho, Prabha Venkatarangan, A. M. Crider, Ahmad A. Adloo, Sharon F. Cruse, Christine N. Hinko, James P. Stables, Peter H. Andersen
Publikováno v:
European Journal of Medicinal Chemistry. 33:23-31
A variety of 2-piperidinecarboxamides were synthesized and evaluated for anticonvulsant activity using the MES and sc PTZ tests in mice and rats. Neurotoxicity was determined by the rotorod test. Several N-(benzyl)-2-piperidinecarboxamides exhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81f8cadfd2d9e6d9a23b8eb322eea73b
https://doi.org/10.1016/s0223-5234(99)80072-5
https://doi.org/10.1016/s0223-5234(99)80072-5
Autor:
M. Ciechanowicz-Rutkowska, P. Serda, Afif A. El-Assadi, Vida A. Farrar, J. Grochowski, G. Filippini, Jacqueline A. Moore, T. Pilati, Christine N. Hinko
Publikováno v:
Journal of Medicinal Chemistry. 36:3517-3525
Continuing structure-activity studies on the anticonvulsant activity of analogs of N-(benzyloxy)-2-azaspiro[4.4]nonane-1,3-dione (2a), which displayed anti-electroshock seizure (MES) activity and a protective index (TD50/ED50) of > 4.5 are reported.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17572772dcb65a3afac0eda462dcffd5
https://doi.org/10.1021/jm00075a005
https://doi.org/10.1021/jm00075a005
Autor:
K. R. Scott, Vida A. Farrar, Christine N. Hinko, Hyejung Chang, Jacqueline A. Moore, Elizabeth I. Tietz, Jesse M. Nicholson, Ivan O. Edafiogho, Erica L. Richardson, Afif A. El-Assadi
Publikováno v:
Journal of Medicinal Chemistry. 36:1947-1955
This report continues the in-depth evaluation of methyl 4-[(p-chlorophenyl)amino]-6-methyl-2-oxocyclohex-3-en-1-oate , 1 (ADD 196022), and methyl 4-(benzylamino)-6-methyl-2-oxocyclohex-3-en-1-oate, 2, two potent anticonvulsant enaminones. These compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1898b1c03f445ac7dfb3e2ccdff675af
https://doi.org/10.1021/jm00066a003
https://doi.org/10.1021/jm00066a003
Autor:
K. R. Scott, Hyejung Chang, Ivan O. Edafiogho, Dianna Mulzac, Jesse M. Nicholson, Christine N. Hinko, Jacqueline A. Moore
Publikováno v:
ChemInform. 23
A new series of novel enaminones has been synthesized from cyclic beta-dicarbonyl precursors which were condensed with morpholine, pyrrolidine, phenethylamine, hydrazines, substituted benzyl amines, and substituted anilines. These compounds were subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::877b5f39e598b9ca23408246942be175
https://doi.org/10.1002/chin.199252137
https://doi.org/10.1002/chin.199252137
Autor:
Sharon F. Cruse, Ahmad A. Adloo, James P. Stables, Christine N. Hinko, David S. Roane, Peter H. Andersen, Prabha Venkatarangan, Bin Ho, A. M. Crider
Publikováno v:
ChemInform. 29
A variety of 2-piperidinecarboxamides were synthesized and evaluated for anticonvulsant activity using the MES and sc PTZ tests in mice and rats. Neurotoxicity was determined by the rotorod test. Several N-(benzyl)-2-piperidinecarboxamides exhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef7958269e7b452c4f8584fd63787271
https://doi.org/10.1002/chin.199827162
https://doi.org/10.1002/chin.199827162
Autor:
M.A. Kliem, Bin Ho, H. Klitgaard, Christine N. Hinko, C.M. Burns, C.L. Steinmiller, Afif A. El-Assadi, A. M. Crider, P. Venkatarangan, Peter H. Andersen, T.H. Seo, Hyejung Chang, Elizabeth I. Tietz
Publikováno v:
Neuropharmacology. 35(12)
The relative ability of derivatives of 2-piperidinecarboxylic acid (2-PC; pipecolic acid) and 3-piperidinecarboxylic acid (3-PC; nipecotic acid) to block maximal electroshock (MES)-induced seizures, elevate the threshold for electroshock-induced seiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a493b44f43fccaef3b3f0e5e32487d
https://pubmed.ncbi.nlm.nih.gov/9076751
https://pubmed.ncbi.nlm.nih.gov/9076751
Autor:
Jesse M. Nicholson, Christine N. Hinko, Hyejung Chang, K. R. Scott, Dianna Mulzac, Jacqueline A. Moore, Ivan O. Edafiogho
Publikováno v:
Journal of medicinal chemistry. 35(15)
A new series of novel enaminones has been synthesized from cyclic beta-dicarbonyl precursors which were condensed with morpholine, pyrrolidine, phenethylamine, hydrazines, substituted benzyl amines, and substituted anilines. These compounds were subs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a83be426b045ee7ab6cbddc8532d12
https://pubmed.ncbi.nlm.nih.gov/1495012
https://pubmed.ncbi.nlm.nih.gov/1495012
Autor:
Charmaine Rozanov, Christine N. Hinko
Publikováno v:
European journal of pharmacology. 182(2)
Ethanol's intoxicating effects may result from ethanol-induced changes in central gamma-aminobutyric acid (GABA) mechanisms. To further test this hypothesis, mice were pretreated with bicuculline (1 mg/kg s.c.), aminooxyacetic acid (15, 20, 25 or 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78df14cbda0ea9858dd3924295bf8ff
https://pubmed.ncbi.nlm.nih.gov/2397743
https://pubmed.ncbi.nlm.nih.gov/2397743
Publikováno v:
Neuropharmacology. 23:1009-1014
The nipecotic acid ester, (±)-m-nitrophenyl-3-piperidinecarboxylate hydrochloride (MNPC) is a potent inhibitor of uptake of GABA in vitro and should be able to penetrate into the brain much more readily than the parent compound nipecotic acid. A stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997821f0d53c90bbd272086de64c551a
https://doi.org/10.1016/0028-3908(84)90121-7
https://doi.org/10.1016/0028-3908(84)90121-7