Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Christine Moulton Clemson"'
Publikováno v:
The Journal of Cell Biology
Genes on different chromosomes can be spatially associated in the nucleus in several transcriptional and regulatory situations; however, the functional significance of such associations remains unclear. Using human erythropoiesis as a model, we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc5a6a40f91edaa47b6507765f4e24c
https://doi.org/10.1083/jcb.200808121
https://doi.org/10.1083/jcb.200808121
Publikováno v:
Chromosoma. 113:324-335
The inactive X chromosome (Xi) forms a heterochromatic structure in the nucleus that is known to have several modifications to specific histones involving acetylation or methylation. Using three different antibodies in four different cell lines, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0c38d1a3495f75a9f8a2f4567bf399
https://doi.org/10.1007/s00412-004-0325-1
https://doi.org/10.1007/s00412-004-0325-1
Autor:
Jeanne B. Lawrence, Jennifer C. Chow, Christine Moulton Clemson, Lisa L. Hall, Carolyn J. Brown
Publikováno v:
Genomics. 82:309-322
X inactivation requires XIST, a functional RNA that is expressed exclusively from, and localizes to, the inactive X in female somatic cells. In mouse, low-level unstable transcription of Xist is observed prior to the time of inactivation, and an anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf5513fe3b70c69c3a0652ef59b89f0
https://doi.org/10.1016/s0888-7543(03)00170-8
https://doi.org/10.1016/s0888-7543(03)00170-8
Publikováno v:
The Journal of Cell Biology
These studies address whether XIST RNA is properly localized to the X chromosome in somatic cells where human XIST expression is reactivated, but fails to result in X inactivation (Tinker, A.V., and C.J. Brown. 1998. Nucl. Acids Res. 26:2935–2940).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::301d8bbee682b3d06e0ef4e4d896462c
https://doi.org/10.1083/jcb.142.1.13
https://doi.org/10.1083/jcb.142.1.13
Publikováno v:
Journal of Cellular Biochemistry. 62:181-190
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ced5e556e5686c778501e784fba49874
https://doi.org/10.1002/(sici)1097-4644(199608)62:2<181::aid-jcb6>3.0.co
https://doi.org/10.1002/(sici)1097-4644(199608)62:2<181::aid-jcb6>3.0.co
Autor:
John M. Dunn, Andrew P. Miller, Patricia A. Hunt, Christine Moulton Clemson, Laura Carrel, Huntington F. Willard, Jeanne B. Lawrence
Publikováno v:
Human Molecular Genetics. 5:391-401
Previously reported data on the X inactivation status of the ubiquitin activating enzyme E1 (UBE1) gene have been contradictory, and the issue has remained unsettled. Here we present three lines of evidence that UBE1 is expressed from the inactive X
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b380434ff80bf33bcfb493d70d573832
https://doi.org/10.1093/hmg/5.3.391
https://doi.org/10.1093/hmg/5.3.391
Publikováno v:
The Journal of Cell Biology
The XIST gene is implicated in X chromosome inactivation, yet the RNA contains no apparent open reading frame. An accumulation of XIST RNA is observed near its site of transcription, the inactive X chromosome (Xi). A series of molecular cytogenetic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39e6c77fec059ff1433845e1f915232
https://doi.org/10.1083/jcb.132.3.259
https://doi.org/10.1083/jcb.132.3.259
Autor:
Alexander W. Ensminger, John N. Hutchinson, Sergio A. Sara, Jeanne B. Lawrence, Archa H. Fox, Andrew Chess, Christine Moulton Clemson
Publikováno v:
Molecular cell. 33(6)
NEAT1 RNA, a highly abundant 4 kb ncRNA, is retained in nuclei in approximately 10 to 20 large foci that we show are completely coincident with paraspeckles, nuclear domains implicated in mRNA nuclear retention. Depletion of NEAT1 RNA via RNAi eradic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a49fd419eb325c35558fa3d8313dfe49
https://pubmed.ncbi.nlm.nih.gov/19217333
https://pubmed.ncbi.nlm.nih.gov/19217333
Autor:
Christine Moulton Clemson, Christopher R. Lynch, John N. Hutchinson, Jeanne B. Lawrence, Alexander W. Ensminger, Andrew Chess
Publikováno v:
BMC Genomics, Vol 8, Iss 1, p 39 (2007)
BMC Genomics
BMC Genomics
Background Noncoding RNA species play a diverse set of roles in the eukaryotic cell. While much recent attention has focused on smaller RNA species, larger noncoding transcripts are also thought to be highly abundant in mammalian cells. To search for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f367f1f4292441b43eab610c4d4da7
https://doi.org/10.1186/1471-2164-8-39
https://doi.org/10.1186/1471-2164-8-39
We investigated whether genes escape X chromosome inactivation by positioning outside of the territory defined by XIST RNA. Results reveal an unanticipated higher order organization of genes and noncoding sequences. All 15 X-linked genes, regardless
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4abe78f1f7fd7ee43934f1af73d721
https://europepmc.org/articles/PMC1472506/
https://europepmc.org/articles/PMC1472506/
