Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Christine Milcarek"'
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 201(10)
In the transition from B cells to Ab-secreting cells (ASCs) many genes are induced, such as ELL2, Irf4, Prdm1, Xbp1, whereas other mRNAs do not change in abundance. Nonetheless, using splicing array technology and mouse splenic B cells plus or minus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb61ec960436d17161ffe7620bf00f8
https://pubmed.ncbi.nlm.nih.gov/30297340
https://pubmed.ncbi.nlm.nih.gov/30297340
Autor:
Sandra, Cascio, Thomas A, Medsger, William F, Hawse, Simon C, Watkins, Christine, Milcarek, Larry W, Moreland, Robert A, Lafyatis, Patrizia, Fuschiotti
Publikováno v:
The Journal of allergy and clinical immunology. 142(1)
IL-13-producing CD8We sought to establish the molecular basis of IL-13 overproduction by CD8Biochemical and biophysical methods were used to determine the expression and association of T-bet, GATA-3, and regulatory factors in CD8Interaction of T-bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d9aaa969a1a39dc5ba0a2e44a5b26083
https://pubmed.ncbi.nlm.nih.gov/29155097
https://pubmed.ncbi.nlm.nih.gov/29155097
Autor:
Ian Bayles, June Liu, Christine Milcarek, Julie R. Boiko, Kyung Soo Park, Alec Szlachta-McGinn, Lisa Borghesi, Patricia M. Santos, Zhou Wang, Joshua Paul
Publikováno v:
The Journal of Immunology. 193:4663-4674
Differentiation of B cells into Ab-secreting cells induces changes in gene transcription, IgH RNA processing, the unfolded protein response (UPR), and cell architecture. The transcription elongation factor eleven nineteen lysine-rich leukemia gene (E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::054d59485217a333544fe8e912b22144
https://doi.org/10.4049/jimmunol.1401608
https://doi.org/10.4049/jimmunol.1401608
Autor:
Christine Milcarek, Ian Bayles
Publikováno v:
Critical Reviews in Immunology. 34:481-499
B cells can be activated by cognate antigen, anti-B-cell receptor antibody, complement receptors, or polyclonal stimulators like lipopolysaccharide; the overall result is a large shift in RNA processing to the secretory-specific form of immunoglobuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653ebc466b51eb66e11a18c51b411737
https://doi.org/10.1615/critrevimmunol.2014012168
https://doi.org/10.1615/critrevimmunol.2014012168
Autor:
Christine Milcarek
Publikováno v:
The Journal of Immunology. 202:123.9-123.9
RNA splicing patterns in antibody-secreting cells are shaped by endoplasmic reticulum stress, ELL2 transcription elongation factor induction, and changes in the levels of snRNAs. Endoplasmic reticulum stress induces the unfolded protein response; amo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e233454f794200830517997729fa2a7a
https://doi.org/10.4049/jimmunol.202.supp.123.9
https://doi.org/10.4049/jimmunol.202.supp.123.9
Publikováno v:
Advances in Bioscience and Biotechnology. :774-780
ELL2 (eleven-nineteen lysine-rich leukemia transcription elongation factor), a component of a larger complex with pTEFb (cyclin T and CDK9) and AF4, is up-regulated in plasma cells where it influences mRNA processing by increasing exon skipping and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8e7fcdbd062c800a03819f6cc8751b4
https://doi.org/10.4236/abb.2013.47101
https://doi.org/10.4236/abb.2013.47101
Publikováno v:
Journal of Biological Chemistry. 286:33795-33803
In plasma cells, immunoglobulin heavy chain (IgH) secretory-specific mRNA is made in high abundance as a result of both increased promoter proximal poly(A) site choice and weak splice-site skipping. Ell2, the eleven-nineteen lysine rich leukemia gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86db86ca54b420d365d3f950210032b7
https://doi.org/10.1074/jbc.m111.272096
https://doi.org/10.1074/jbc.m111.272096
Publikováno v:
Immunologic Research. 50:105-112
B cell development starts in the bone marrow where hematopoietic stem cells (HSCs) progress through sequential developmental stages, as it differentiates into a naïve B cell expressing surface immunoglobulin. In the periphery, B cells that encounter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50d311aa044b520dedbe17ab240dd79f
https://doi.org/10.1007/s12026-011-8225-y
https://doi.org/10.1007/s12026-011-8225-y
Autor:
Kathleen Martincic, S.M.L.C. Mendis-Handagama, Brinda Dass, Lisa Borghesi, Christine Milcarek, Clinton C. MacDonald, Kathy Jo Hockert
Publikováno v:
Journal of Reproductive Immunology. 89:26-37
Alternative polyadenylation controls expression of genes in many tissues including immune cells and male germ cells. The τCstF-64 polyadenylation protein is expressed in both cell types, and we previously showed that Cstf2t, the gene encoding τCstF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7f069485f9138760467b153f00eeede
https://doi.org/10.1016/j.jri.2011.01.018
https://doi.org/10.1016/j.jri.2011.01.018
Autor:
Simon C. Watkins, Christine Milcarek, Robert Lafyatis, Thomas A. Medsger, Patrizia Fuschiotti, William F. Hawse, Larry W. Moreland, Sandra Cascio
Publikováno v:
Journal of Allergy and Clinical Immunology. 142:109-119.e6
Background IL-13–producing CD8 + T cells have been implicated in the pathogenesis of type 2–driven inflammatory human conditions. We have shown that CD8 + IL-13 + cells play a critical role in cutaneous fibrosis, the most characteristic feature o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7657809ffe03e5c0cf0f5324d9ac95cd
https://doi.org/10.1016/j.jaci.2017.10.029
https://doi.org/10.1016/j.jaci.2017.10.029