Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christine Meck"'
Autor:
John A. Beutler, Takashi Masaoka, Baofeng Zhang, Rajat K. Pal, Michael P. D'Erasmo, Christine Meck, Jennifer A. Wilson, Danielle R. Hirsch, Stuart F.J. Le Grice, Emilio Gallicchio, Ryan P. Murelli
Publikováno v:
MedChemComm. 7:1783-1788
HIV Reverse Transcriptase-associated ribonuclease H activity is a promising enzymatic target for drug development that has not been successfully targeted in the clinic. While the α-hydroxytropolone-containing natural products β-thujaplicinol and ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ea992066e20109c2362f02ab54c9f6e
https://doi.org/10.1039/c6md00238b
https://doi.org/10.1039/c6md00238b
Autor:
Gerard D. Wright, Noushad Mohd, Michael P. D'Erasmo, Christine Meck, Danielle R. Hirsch, Georgina Cox, Tushar Shakya, Ryan P. Murelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4943-4947
Aminoglycoside-2″-O-nucleotidyltransferase ANT(2″)-Ia is an aminoglycoside resistance enzyme prevalent among Gram-negative bacteria, and is one of the most common determinants of enzyme-dependant aminoglycoside-resistance. The following report ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c8ff965dad490bbf7b3ee2e92e07dd4
https://doi.org/10.1016/j.bmcl.2014.09.037
https://doi.org/10.1016/j.bmcl.2014.09.037
Publikováno v:
Med. Chem. Commun.. 5:842-852
α-Hydroxytropolones are a subclass of the troponoid family of natural products that are of high interest due to their broad biological activity and potential as treatment options for several diseases. Despite this promise, there have been scarce syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427caa84fea3740f0144f8dce81443a2
https://doi.org/10.1039/c4md00055b
https://doi.org/10.1039/c4md00055b
Publikováno v:
ChemInform. 47
α-Hydroxy-γ-pyrone-based oxidopyrylium cycloaddition reactions are useful methods for accessing a highly diverse range of oxabicyclo[3.2.1]octane products. Intermolecular variants of the reaction require the formation of a methyl triflate-based pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb70ca575d0bd804ed64d3b82f6fe5c2
https://doi.org/10.1002/chin.201638116
https://doi.org/10.1002/chin.201638116
Publikováno v:
ChemInform. 46
α-Hydroxytropolones are a subclass of the troponoid family of natural products that are of high interest due to their broad biological activity and potential as treatment options for several diseases. Despite this promise, there have been scarce syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4462c4f1984bc2ff4aa9049371db6c4
https://doi.org/10.1002/chin.201506281
https://doi.org/10.1002/chin.201506281
Autor:
John E. Tavis, Michael P. D'Erasmo, Elena Lomonosova, Jian-kang Jiang, Christine Meck, Eileen A. Moran, Xiaohong Cheng, Marvin J. Meyers, Danielle R. Hirsch, Duygu M. Suyabatmaz, Craig J. Thomas, Gaofeng Lu, Ryan P. Murelli, Stuart F.J. Le Grice
Publikováno v:
Antimicrobial agents and chemotherapy. 59(2)
Hepatitis B virus (HBV) remains a major human pathogen despite the development of both antiviral drugs and a vaccine, in part because the current therapies do not suppress HBV replication far enough to eradicate the virus. Here, we screened 51 tropon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993eae938d0ba2c3a6fe1d84a8e1b621
https://pubmed.ncbi.nlm.nih.gov/25451058
https://pubmed.ncbi.nlm.nih.gov/25451058
Publikováno v:
ChemInform. 45
Methoxytropolones are useful scaffolds for therapeutic development because of their known biological activity and established value in the synthesis of α-hydroxytropolones. Upon treatment with triflic acid, a series of 3-methoxy-8-oxabicyclo[3.2.1]o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6cdfe08e2e8fb9010a919c89c67e310
https://doi.org/10.1002/chin.201419034
https://doi.org/10.1002/chin.201419034
Methoxytropolones are useful scaffolds for therapeutic development because of their known biological activity and established value in the synthesis of α-hydroxytropolones. Upon treatment with triflic acid, a series of 3-methoxy-8-oxabicyclo[3.2.1]o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f236dbaea81ef6032560fe3408623b28
https://europepmc.org/articles/PMC3909939/
https://europepmc.org/articles/PMC3909939/
Publikováno v:
ChemInform. 44
Title compounds are generated by a BCl3-mediated ring-opening/aromatization/demethylation process of oxabicyclo[3.2.1]octenes which are obtained from the cycloaddition of oxidopyrylium triflates (I) with various alkynes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ec1898e1a521df736d30689cae0c492
https://doi.org/10.1002/chin.201320069
https://doi.org/10.1002/chin.201320069
α-Hydroxytropolones are a class of molecules with therapeutic potential against several human diseases. However, structure-activity relationship studies on these molecules have been limited due to a scarcity of efficient synthetic methods to access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7610baa53f3e21a52e567371dfff136f
https://europepmc.org/articles/PMC3518617/
https://europepmc.org/articles/PMC3518617/