Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Christine Mauck"'
Autor:
Raina N. Fichorova, Pai-Lien Chen, Charles S. Morrison, Gustavo F. Doncel, Kevin Mendonca, Cynthia Kwok, Tsungai Chipato, Robert Salata, Christine Mauck
Publikováno v:
mBio, Vol 6, Iss 5 (2015)
ABSTRACT Particular types of hormonal contraceptives (HCs) and genital tract infections have been independently associated with risk of HIV-1 acquisition. We examined whether immunity in women using injectable depot medroxyprogesterone acetate (DMPA)
Externí odkaz:
https://doaj.org/article/319867ed50f64d4bba24e692fc874259
Autor:
Ian Mcgowan, Ross D Cranston, Kathryn Duffill, Aaron Siegel, Jarret C Engstrom, Alexyi Nikiforov, Cindy Jacobson, Khaja K Rehman, Julie Elliott, Elena Khanukhova, Kaleab Abebe, Christine Mauck, Hans M L Spiegel, Charlene S Dezzutti, Lisa C Rohan, Mark A Marzinke, Hiwot Hiruy, Craig W Hendrix, Nicola Richardson-Harman, Peter A Anton
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125363 (2015)
The CHARM-01 study characterized the safety, acceptability, pharmacokinetics (PK), and pharmacodynamics (PD) of three tenofovir (TFV) gels for rectal application. The vaginal formulation (VF) gel was previously used in the CAPRISA 004 and VOICE vagin
Externí odkaz:
https://doaj.org/article/2b34f4f71e194ee9b4595419b03dbb92
Autor:
Nicola Richardson-Harman, Craig W Hendrix, Namandjé N Bumpus, Christine Mauck, Ross D Cranston, Kuo Yang, Julie Elliott, Karen Tanner, Ian McGowan, Angela Kashuba, Peter A Anton
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111507 (2014)
This study was designed to assess the dose-response relationship between tissue, blood, vaginal and rectal compartment concentrations of tenofovir (TFV) and tenofovir diphosphate (TFVdp) and ex vivo rectal HIV suppression following oral tenofovir dis
Externí odkaz:
https://doaj.org/article/f70bae59fc544b72b18cb743db316f16
Autor:
Kuo-Hsiung Yang, Craig Hendrix, Namandje Bumpus, Julie Elliott, Karen Tanner, Christine Mauck, Ross Cranston, Ian McGowan, Nicola Richardson-Harman, Peter A Anton, Angela D M Kashuba
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e106196 (2014)
This Phase 1, randomized, two-site (United States), double-blind, placebo-controlled study enrolled 18 sexually abstinent men and women. All received a single 300-mg dose of oral tenofovir disoproxil fumarate (TDF) and were then randomized 2:1 to rec
Externí odkaz:
https://doaj.org/article/9f2b358de802411cacb2075532cf09b7
Autor:
Peter A Anton, Terry Saunders, Julie Elliott, Elena Khanukhova, Robert Dennis, Amy Adler, Galen Cortina, Karen Tanner, John Boscardin, William G Cumberland, Ying Zhou, Ana Ventuneac, Alex Carballo-Diéguez, Lorna Rabe, Timothy McCormick, Henry Gabelnick, Christine Mauck, Ian McGowan
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e23243 (2011)
Successful control of the HIV/AIDS pandemic requires reduction of HIV-1 transmission at sexually-exposed mucosae. No prevention studies of the higher-risk rectal compartment exist. We report the first-in-field Phase 1 trial of a rectally-applied, vag
Externí odkaz:
https://doaj.org/article/1fb606f9536c4d42a9fae0b13f7e6ffe
Autor:
Christine Mauck, Sharon L. Hillier, Judy Gendreau, Clint Dart, Hongsheng Wu, Steven Chavoustie, Valerie Sorkin-Wells, Clifton Scott Nicholson-Uhl, Brandon Perez, Mark Jacobs, Nadene Zack, David Friend
Publikováno v:
Clinical Therapeutics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10588d203092317e0ffb89e9400e50ef
https://doi.org/10.1016/j.clinthera.2023.04.001
https://doi.org/10.1016/j.clinthera.2023.04.001
Autor:
Christine Mauck, Sharon L. Hillier, Judy Gendreau, Clint Dart, Steven Chavoustie, Valerie Sorkin-Wells, Clifton Nicholson-Uhl, Brandon Perez, Mark Jacobs, Nadene Zack, David Friend
Publikováno v:
Obstetrics and gynecology. 139(6)
To assess efficacy and safety of a single-dose vaginal clindamycin gel for bacterial vaginosis treatment.We conducted a double-blind, placebo-controlled, randomized study comparing clindamycin gel with placebo (2:1 ratio). Entry required clinical dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d9ac494936661a7cc6a79d323c2418
https://pubmed.ncbi.nlm.nih.gov/35675606
https://pubmed.ncbi.nlm.nih.gov/35675606
Autor:
Judith Absalon, Antonia Kwiecien, Jessica Justman, Christine Mauck, Wafaa El-Sadr, Craig J. Hoesley, Fang Gai, Benoît Mâsse, Lisa Maslankowski, Lydia Soto-Torres, Kenneth H. Mayer, Kathleen M. Morrow
Publikováno v:
AIDS. 20:1109-1116
Objectives: Few studies of topical microbicides have assessed their safety in HIV-infected women. We conducted this study to evaluate the safety and acceptability of 6% cellulose sulfate (CS) gel as a vaginal microbicide in sexually abstinent and act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da0d6b0c38402e3fe21a1ffb12f74a62
https://doi.org/10.1097/01.aids.0000226950.72223.5f
https://doi.org/10.1097/01.aids.0000226950.72223.5f
Publikováno v:
Current topics in microbiology and immunology. 383
Guidelines for establishing clinical safety of microbicides in early clinical studies have evolved significantly since the first trials. In addition, because of the difficulty of establishing efficacy of a microbicide prior to Phase III testing, ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5780657e1ce1f65727688c317c16f4c1
https://pubmed.ncbi.nlm.nih.gov/24173586
https://pubmed.ncbi.nlm.nih.gov/24173586