Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Christine M. Stellrecht"'
Autor:
Aloke Sarkar, Christine M. Stellrecht, Hima V. Vangapandu, Mary Ayres, Benny A. Kaipparettu, Jun Hyoung Park, Kumudha Balakrishnan, Jared K. Burks, Tej K. Pandita, Walter N. Hittelman, Sattva S. Neelapu, Varsha Gandhi
Publikováno v:
Haematologica, Vol 106, Iss 2 (2020)
Ataxia telangiectasia mutated (ATM), a critical DNA damage sensor with protein kinase activity,is frequently altered in human cancers including mantle cell lymphoma (MCL). Loss of ATM protein is linked to accumulation of nonfunctional mitochondria an
Externí odkaz:
https://doaj.org/article/b181e60a525a43df852e14acff5c85e6
Autor:
Hima V. Vangapandu, Mary L. Ayres, Christopher A. Bristow, William G. Wierda, Michael J. Keating, Kumudha Balakrishnan, Christine M. Stellrecht, Varsha Gandhi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 19, Iss 10, Pp 762-771 (2017)
Peripheral blood chronic lymphocytic leukemia (CLL) cells are replicationally quiescent mature B-cells. In short-term cultures, supporting stromal cells provide a survival advantage to CLL cells by inducing transcription and translation without promo
Externí odkaz:
https://doaj.org/article/0f575792f8474370a5f9c493e6bd5062
Autor:
Shadia Zaman, Shujun Shentu, Jing Yang, Jin He, Robert Z. Orlowski, Christine M. Stellrecht, Varsha Gandhi
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 3, Pp 289-300 (2015)
The hepatocyte growth factor (HGF)/MNNG HOS transforming gene (MET) pathway regulates cell growth, survival, and migration. MET is mutated or amplified in several malignancies. In myeloma, MET is not mutated, but patients have high plasma concentrati
Externí odkaz:
https://doaj.org/article/b9b667cf4d444136a96379f6d7509b96
Autor:
Christine M. Stellrecht, Varsha Gandhi
Publikováno v:
BioTechniques, Vol 33, Iss 5, Pp 1122-1124 (2002)
Externí odkaz:
https://doaj.org/article/2564d19a17ad4a3fa594a7d1bb430edd
Autor:
John V. Heymach, Varsha Gandhi, John D. Minna, Ferdinandos Skoulidis, Jing Wang, William G. Wierda, Monique Nilsson, Jayanthi Gudikote, Uma Giri, Jie Ding, Lixia Diao, Pan Tong, Youhong Fan, Mary L. Ayres, Ishita Akhter, Xiao Qu, Yu Qian, Chao Yang, Emrullah Yilmaz, Christine M. Stellrecht, Ana Galan-Cobo
Supplementary Data from Enhanced Vulnerability of LKB1-Deficient NSCLC to Disruption of ATP Pools and Redox Homeostasis by 8-Cl-Ado
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258bef6377c0c92b6a9aa53b41a98b39
https://doi.org/10.1158/1541-7786.22527521.v1
https://doi.org/10.1158/1541-7786.22527521.v1
Autor:
Varsha Gandhi, Christine M. Stellrecht, R. Eric Davis, Michael J. Keating, William G. Wierda, Kumudha Balakrishnan, Benny Abraham Kaipparettu, Mary L. Ayres, Ondrej Havranek, Hima V. Vangapandu
Peripheral blood chronic lymphocytic leukemia (CLL) cells are quiescent but have active transcription and translation processes, suggesting that these lymphocytes are metabolically active. Based on this premise, the metabolic phenotype of CLL lymphoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::38046ccb772f97edfcbe3723f9b905be
https://doi.org/10.1158/1541-7786.c.6541188
https://doi.org/10.1158/1541-7786.c.6541188
Autor:
Varsha Gandhi, Christine M. Stellrecht, R. Eric Davis, Michael J. Keating, William G. Wierda, Kumudha Balakrishnan, Benny Abraham Kaipparettu, Mary L. Ayres, Ondrej Havranek, Hima V. Vangapandu
Supplemental Figure 1. Graphical representation of extracellular flux stress profiles from a CLL patient. Supplemental Figure 2. Sorting BCR knockout cells from Cas9 transfected JeKo-1 cells. Supplemental Figure 3. Sorting PIK3CD knockout cells from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90dfc1e26b1c8dcd303bc5df23531b01
https://doi.org/10.1158/1541-7786.22515804.v1
https://doi.org/10.1158/1541-7786.22515804.v1
Autor:
Varsha Gandhi, Christine M. Stellrecht, R. Eric Davis, Michael J. Keating, William G. Wierda, Kumudha Balakrishnan, Benny Abraham Kaipparettu, Mary L. Ayres, Ondrej Havranek, Hima V. Vangapandu
Supplemental Table 1 showing patient characteristics.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00b9ce3112d4365a6d44445e982cb77
https://doi.org/10.1158/1541-7786.22515801
https://doi.org/10.1158/1541-7786.22515801
Multiple myeloma (MM) is an invariably fatal plasma cell malignancy, primarily due to the therapeutic resistance which ultimately arises. Much of the resistance results from the expression of various survival factors. Despite this, the ribonucleoside
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54a51bf026d9fdb41438b37922ce7b5d
https://doi.org/10.1158/0008-5472.c.6496884
https://doi.org/10.1158/0008-5472.c.6496884
Publikováno v:
Nucleosides, Nucleotides & Nucleic Acids. 41:1359-1374
8-Chloro-adenosine (8-Cl-Ado) is currently in phase I clinical trial. Activation of p53 and transactivation of p21 regulate cell fate after genotoxic insult. Using HCT-116-isogenic-cell-lines, we evaluated the role of p53/p21 after 8-Cl-Ado-mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043fd873f19a1ec07c0bab0561cae795
https://doi.org/10.1080/15257770.2022.2038200
https://doi.org/10.1080/15257770.2022.2038200