Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Christine M. Smyth"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Protein colocalisation is often studied using pixel intensity-based coefficients such as Pearson, Manders, Li or Costes. However, these methods cannot be used to study object-based colocalisations in biological systems. Therefore, a novel me
Externí odkaz:
https://doaj.org/article/2faddc290bb648358aa38548d73e9b1a
Autor:
Helen Doyle, Mawj Mandwie, Peter J. Lachmann, Talat H. Malik, Ian E. Alexander, Matthew C. Pickering, Amina Ahmad, Christine M. Smyth, Grant J Logan, Anna K. Dreismann
Publikováno v:
Human Gene Therapy.
The complement system is a key component of innate immunity, but impaired regulation influences disease susceptibility, including age-related macular degeneration and some kidney diseases. While complete complement inhibition has been used successful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77551bbc36e282ee491dfaf4ab15c440
https://doi.org/10.1089/hum.2021.022
https://doi.org/10.1089/hum.2021.022
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Protein colocalisation is often studied using pixel intensity-based coefficients such as Pearson, Manders, Li or Costes. However, these methods cannot be used to study object-based colocalisations in biological systems. Therefore, a novel method is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc3c8b3f8035f74c640694cbaefb284b
http://europepmc.org/articles/PMC5566543
http://europepmc.org/articles/PMC5566543
Autor:
Emilie E. Wilkie, Christine M. Smyth, Grant J Logan, Claus V. Hallwirth, Anais K. Amaya, Neeta Khandekar, Sophia H.Y. Liao, Allison P Dane, Leszek Lisowski, Sharon C. Cunningham, David W. Russell, Patrick P.L. Tam, Marti Cabanes-Creus, Ian E. Alexander, Samantha L. Ginn, Erhua Zhu, Natsuki Sasaki
Publikováno v:
Nature genetics. 49(8)
Vectors based on adeno-associated virus type 2 (AAV2) are powerful tools for gene transfer and genome editing applications. The level of interest in this system has recently surged in response to reports of therapeutic efficacy in human clinical tria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89c42d12f92cc091f041a3d030cec81
https://pubmed.ncbi.nlm.nih.gov/28628105
https://pubmed.ncbi.nlm.nih.gov/28628105
Publikováno v:
Blood. 110:91-98
X-linked severe combined immunodeficiency (SCID-X1) results from mutations in the IL2RG gene, which encodes the common gamma chain (gammac) of the receptors for interleukin (IL)-2, 4, 7, 9, 15, and 21. Affected infants typically lack T and natural ki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a31eb69c88ba10d71ecf83b230bcab0
https://doi.org/10.1182/blood-2006-11-055442
https://doi.org/10.1182/blood-2006-11-055442
Autor:
Christine M. Smyth, Ken H. Woo, Grant J. Logan, George C.T. Yeoh, Sharon C. Cunningham, Ian E. Alexander, Jessica R. Trippit, Gustavo de Alencastro
Publikováno v:
Molecular Therapy. 23
Liver progenitor cells (LPC) possess significant potential as a cellular therapy as they are easily isolated, can differentiate into hepatocytes and cholangiocytes and maintain stable phenotype in long-term culture. However, their use to correct rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20bbd68b22deed5d73111aa44168b28
Autor:
Maolin Zheng, Peter B. Rowe, Christine M. Smyth, Belinda Kramer, Sharon C. Cunningham, Alain Fischer, Margot Latham, Ian E. Alexander, Debbie Watson, Alyson Kakakios, Julie Curtin, Geoffrey McCowage, Stephen I. Alexander, Linda Hobson, Samantha L. Ginn, Melanie Wong, Marina Cavazzana-Calvo, Salima Hacein-Bey-Abina
Publikováno v:
Medical Journal of Australia. 182:458-463
OBJECTIVE To report the outcome of gene therapy in an infant with X-linked severe combined immunodeficiency (SCID-X1), which typically causes a lack of T and natural killer (NK) cells. DESIGN AND SETTING Ex-vivo culture and gene transfer procedures w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9975df271ad1c780aad42c4c7a2c7489
https://doi.org/10.5694/j.1326-5377.2005.tb06785.x
https://doi.org/10.5694/j.1326-5377.2005.tb06785.x
Autor:
Peter B. Rowe, Jason A. Smythe, Ross Boadle, Grant J Logan, Ian E. Alexander, Christine M. Smyth
Publikováno v:
International Immunology. 17:123-132
We have previously reported the presence of a discrete reservoir of the costimulatory molecule CD86 in the cytoplasm of human monocytes freshly isolated from peripheral blood mononuclear cells (PBMC). In the current study, we have extended analysis o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6de956734c14cd12cbab6526f5d8a21
https://doi.org/10.1093/intimm/dxh193
https://doi.org/10.1093/intimm/dxh193
Autor:
Allison P Dane, Ian E. Alexander, Christine M. Smyth, Grant J Logan, Claus V. Hallwirth, Sophia Laio, Samantha L. Ginn, Neeta Khandekar
Publikováno v:
Molecular Therapy. 24:S119-S120
We have discovered a novel anti-sense promoter element in nucleotides proximal to the right ITR of AAV serotype 2. Presence of the element was initially detected using vector derived from psub201, a widely-used plasmid for AAV vectorization which car
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ff94366ad4c095d386769e2531c8784
https://doi.org/10.1016/s1525-0016(16)33107-0
https://doi.org/10.1016/s1525-0016(16)33107-0
Publikováno v:
Pathology. 25:388-393
Cell ploidy and proliferative activity may be useful to clinicians in treating children with solid tumors. Frozen specimens from children with malignant solid tumors were tested at the time of diagnosis for ploidy and proliferative activity. The flow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7df6daae73cea5aedec073737e18af7
https://doi.org/10.3109/00313029309090865
https://doi.org/10.3109/00313029309090865