Výsledky vyhledávání - "Christine M. Perella"

Data from Dominant-Negative Activator Protein 1 (TAM67) Targets Cyclooxygenase-2 and Osteopontin under Conditions in which It Specifically Inhibits Tumorigenesis

Autor: Nancy H. Colburn, Matthew R. Young, George R. Beck, Christine M. Perella, Alyson R. Baker, Alysia M. Birkholz, Connie P. Matthews

Activation of activator protein 1 (AP-1) and nuclear factor κB (NFκB)–dependent transcription is required for tumor promotion in cell culture models and transgenic mice. Dominant-negative c-Jun (TAM67) blocks AP-1 activation by dimerizing with Ju

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47217f02b39d0d866db4ba50c2f351b3
https://doi.org/10.1158/0008-5472.c.6494877.v1

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Akademický článek

Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFα.

Autor: Mohamed E Moustafa, Bradley A Carlson, Miriam R Anver, Gerd Bobe, Nianxin Zhong, Jerrold M Ward, Christine M Perella, Victoria J Hoffmann, Keith Rogers, Gerald F Combs, Ulrich Schweizer, Glenn Merlino, Vadim N Gladyshev, Dolph L Hatfield

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57389 (2013)

Changes in dietary selenium and selenoprotein status may influence both anti- and pro-cancer pathways, making the outcome of interventions different from one study to another. To characterize such outcomes in a defined setting, we undertook a control

Externí odkaz: https://doaj.org/article/d0eb1189879c4990a6bcca0f73d4e755

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Retrovirus-transformed erythroleukemia cells induce central nervous system failure in a new syngeneic mouse model of meningeal leukemia

Autor: Charlotte Hanson, Sandra K. Ruscetti, Joan L. Cmarik, Christine M. Perella, Gordon R. Macpherson, Delores Thompson

Publikováno v: Leukemia Research. 36:369-376

Lack of suitable mouse models for central nervous system (CNS)-associated leukemias has hindered mechanism-guided development of therapeutics. By transplanting retrovirus-transformed mouse erythroleukemia cells into syngeneic mice, we developed a new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4461411ff4635f7ad6cf7f4da00a0b5
https://doi.org/10.1016/j.leukres.2011.08.019

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The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice

Autor: Svetlana Speransky, Dolph L. Hatfield, Lionel Feigenbaum, Thomas Floss, Vadim N. Gladyshev, Christine M. Perella, Rajeev K. Shrimali, Gerald F. Combs, Liya Shen, Victoria Hoffmann, Bradley A. Carlson, Soon Jeong Jeong, Jennifer C Watts, Ulrich Schweizer

Publikováno v: Biochemical Journal. 418:61-71

STAF [Sec (selenocysteine) tRNA gene transcription activating factor] is a transcription activating factor for a number of RNA Pol III- and RNA Pol II-dependent genes including the Trsp [Sec tRNA gene], which in turn controls the expression of all se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde0e092473751a247e159257b6be9ab
https://doi.org/10.1042/bj20081304

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Decreased Selenoprotein Expression Alters the Immune Response during Influenza Virus Infection in Mice

Autor: Patricia A. Sheridan, Dolph L. Hatfield, Christine M. Perella, Nianxin Zhong, Bradley A. Carlson, Melinda A. Beck

Publikováno v: The Journal of Nutrition. 137:1466-1471

Previous work from our laboratory demonstrated that host selenium (Se) deficiency results in greater lung pathology and altered immune function in mice infected with influenza virus. Because selenoproteins play a key role in determining the oxidant s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3deb4038fbb251936e29457dd88d87b
https://doi.org/10.1093/jn/137.6.1466

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A novel retrovirus provides the cooperating oncogenic event(s) required to demonstrate the tumor suppressor activity of p15Ink4b in myeloid cells in vivo

Autor: Matthew T. Garin, Christine M. Perella, Douglas Powell, Linda Wolff, Lino Tessarollo, Juraj Bies, Miriam R. Anver, Richard Koller

Publikováno v: Blood Cells, Molecules, and Diseases. 32:226-231

Cancer is a multistep process resulting from an accumulation of several genetic changes. The determination of cooperating events in experimental models can help scientists decipher specific neoplastic pathways and place genes with similar functions i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34324528addfbe3188c9dede01957424
https://doi.org/10.1016/j.bcmd.2003.09.006

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Decrease in K-ras p21 and Increase in Raf1 and Activated Erk 1 and 2 in Murine Lung Tumors Initiated by N-Nitrosodimethylamine and Promoted by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Autor: Christine M. Perella, Bhalchandra A. Diwan, Lisa Birely, Gayatri Ramakrishna, Lucy M. Anderson, Laura W. Fornwald

Publikováno v: Toxicology and Applied Pharmacology. 179:21-34

Recent evidence suggests that K-ras protooncogene protein p21 may have a tumor-suppressive role in the context of development of lung adenocarcinoma. Levels of K-ras p21, raf-1, mitogen-activated protein kinases Erk 1 and 2, the phosphorylated-activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752cbf9173689410b85f8c453ee2f844
https://doi.org/10.1006/taap.2001.9344

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Ki-ras and the Characteristics of Mouse Lung Tumors

Autor: Christine M. Perella, Yih-Horng Shiao, Lucy M. Anderson, Bhalchandra A. Diwan, Aneta Bialkowska, Lisa Birely, Laura W. Fornwald, Gayatri Ramakrishna

Publikováno v: Molecular Carcinogenesis. 28:156-167

Codon 12 mutations are frequent in the Ki-ras oncogene in human lung adenocarcinomas, but the effects of these alterations have not been well characterized in lung epithelial cells. Murine primary lung tumors derived from peripheral epithelial cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13971efdb9a2754f2707701c28f15924
https://doi.org/10.1002/1098-2744(200007)28:3<156::aid-mc4>3.0.co

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Receptor and Nonreceptor-Mediated Organ-Specific Toxicity of Di(2-ethylhexyl)phthalate (DEHP) in Peroxisome Proliferator-Activated Receptorα-Null Mice

Autor: Jeffrey M. Peters, Jerrold M. Ward, Frank J. Gonzalez, Christine M. Perella

Publikováno v: Toxicologic Pathology. 26:240-246

The peroxisome proliferator-activated receptor alpha (PPAR alpha) is the mediator of the biological effects of peroxisome proliferators through control of gene transcription. To determine if the toxic effects of di(2-ethylhexyl)phthalate (DEHP) are m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0473cedee777180bebe2a61da7193171
https://doi.org/10.1177/019262339802600208

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