Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Christine M. O'Connor"'
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Human cytomegalovirus (HCMV) is a betaherpesvirus that establishes lifelong infection in its host and can cause severe comorbidities in individuals with suppressed or compromised immune systems. The lifecycle of HCMV consists of lytic and la
Externí odkaz:
https://doaj.org/article/1baa590fe0aa4c9890996d03c17d6e98
Publikováno v:
Applied Nano, Vol 3, Iss 2, Pp 91-101 (2022)
Mycotoxins are secondary metabolic products of fungi. They are poisonous, carcinogenic, and mutagenic in nature and pose a serious health threat to both humans and animals, causing severe illnesses and even death. Rapid, simple and low-cost methods o
Externí odkaz:
https://doaj.org/article/06c6bd8b60f841f09b38084f1d0d138f
Publikováno v:
Virology Journal, Vol 18, Iss 1, Pp 1-17 (2021)
Abstract Background Human cytomegalovirus (HCMV) resides latently in cells of the myeloid compartment, including CD34+ hematopoietic progenitor cells and circulating monocytes. Healthy hosts maintain the virus latently, and this infection is, for the
Externí odkaz:
https://doaj.org/article/4ba9bfc59da84db0946127d8e948076b
Publikováno v:
Viruses, Vol 14, Iss 6, p 1280 (2022)
Human cytomegalovirus (CMV) is a ubiquitous pathogen that latently resides in hematopoietic cells. Latently infected individuals with dysfunctional immune systems often experience CMV reactivation, which can cause devastating disease and mortality. W
Externí odkaz:
https://doaj.org/article/a540565c85e54527bd4424d28d9b06ed
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
The ability to establish a latent infection with periodic reactivation events ensures herpesviruses, like human cytomegalovirus (HCMV), lifelong infection, and serial passage. The host-pathogen relationship throughout HCMV latency is complex, though
Externí odkaz:
https://doaj.org/article/c03b295376a140a098b2b4c5d763d5f1
Autor:
Elizabeth G. Elder, Benjamin A. Krishna, James Williamson, Eleanor Y. Lim, Emma Poole, George X. Sedikides, Mark Wills, Christine M. O’Connor, Paul J. Lehner, John Sinclair
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Human cytomegalovirus (HCMV) latency is an active process which remodels the latently infected cell to optimize latent carriage and reactivation. This is achieved, in part, through the expression of viral genes, including the G-protein-coupl
Externí odkaz:
https://doaj.org/article/380acf94ae2e407ba81bc144361f8da4
Autor:
Christine M. O’Connor, Ganes C. Sen
Publikováno v:
Cells, Vol 10, Iss 8, p 2122 (2021)
Infection of a host cell by an invading viral pathogen triggers a multifaceted antiviral response. One of the most potent defense mechanisms host cells possess is the interferon (IFN) system, which initiates a targeted, coordinated attack against var
Externí odkaz:
https://doaj.org/article/e7d3161dc5624474a40addc4139666e7
Autor:
Christine M. O’Connor
Publikováno v:
Pathogens, Vol 10, Iss 3, p 342 (2021)
Cytomegalovirus (CMV) is a herpesvirus that infects a majority of the human population worldwide [...]
Externí odkaz:
https://doaj.org/article/3abd210c6400414dab05f3298237ee2e
Publikováno v:
Pathogens, Vol 9, Iss 11, p 869 (2020)
Human cytomegalovirus (HCMV) is a ubiquitous herpesviral pathogen that results in life-long infection. HCMV maintains a latent or quiescent infection in hematopoietic cells, which is broadly defined by transcriptional silencing and the absence of de
Externí odkaz:
https://doaj.org/article/1631ec4be31942a4aeb8dab0070337aa
The AP-1 Transcription Factor Is a Key Determinant of Human Cytomegalovirus Latency and Reactivation
Publikováno v:
Proceedings, Vol 50, Iss 1, p 127 (2020)
Human cytomegalovirus (HCMV) is a ubiquitous pathogen that latently infects hematopoietic progenitor cells (HPCs). Individuals with a competent immune system are, for the most part, asymptomatic for the disease. However when a latently infected indiv
Externí odkaz:
https://doaj.org/article/b51b54a6af404844bc1c0b27fa9f0e58