Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Christine M. Misquitta"'
Autor:
Kim Blakely, Philip M. Kim, Dahlia Kasimer, David A. Hood, Andrea Uetrecht, Kevin A. Brown, Alessandro Datti, Patricia Mero, Sachin Kumar, Ayesha Saleem, Christine M. Misquitta, Roland Arnold, Jason Moffat
A central focus of systems biology is the functional mapping of protein-protein interactions under physiological conditions. Here we describe MaGiCaL-BiFC, a lentivirus-based bimolecular fluorescence protein-fragment complementation approach for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c87ea151b30a73598565806f5ffea07d
https://doi.org/10.1101/770669
https://doi.org/10.1101/770669
Autor:
Ni Liu, Edith Cheng, C. Jane McGlade, Ming-Sound Tsao, Benjamin J. Blencowe, Christine M. Misquitta-Ali, Dave O'Hanlon
Publikováno v:
Molecular and Cellular Biology. 31:138-150
Alternative splicing (AS) is a widespread mechanism underlying the generation of proteomic and regulatory complexity. However, which of the myriad of human AS events play important roles in disease is largely unknown. To identify frequently occurring
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a009adab1f5985593a5acbf4169606
https://doi.org/10.1128/mcb.00709-10
https://doi.org/10.1128/mcb.00709-10
Publikováno v:
Cell Calcium. 41:581-592
Gene expression is controlled at several levels including mRNA decay. Sarco/endoplasmic reticulum Ca2+–Mg2+-ATPase isoform 2b (SERCA2b) is central to Ca2+ signalling and homeostasis in several tissues. SERCA2b mRNA decay involves interactions betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca3e23b147922fa6d238eeb02f1e83c8
https://doi.org/10.1016/j.ceca.2006.10.008
https://doi.org/10.1016/j.ceca.2006.10.008
Autor:
Qun Pan, Lynne E. Maquat, Yoon Ki Kim, Arneet L. Saltzman, Christine M. Misquitta, Benjamin J. Blencowe, Brendan J. Frey, Ofer Shai
Publikováno v:
Genes & Development. 20:153-158
Sequence-based analyses have predicted that ∼35% of mammalian alternative splicing (AS) events produce premature termination codon (PTC)-containing splice variants that are targeted by the process of nonsense-mediated mRNA decay (NMD). This led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1fce4a8c80179bb1ffaa048296196ff
https://doi.org/10.1101/gad.1382806
https://doi.org/10.1101/gad.1382806
Publikováno v:
Biochemical Journal. 388:291-297
Alternative splicing at position 3495 b yields SERCA2 (sarco/endoplasmic reticulum Ca2+ pump 2) RNA species, namely SERCA2a and SERCA2b which differ in 3′-end regions. This results in SERCA2b RNA being less stable. In vitro decay experiments show t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01b6072dff8bcf6a0bce7efa60344075
https://doi.org/10.1042/bj20041568
https://doi.org/10.1042/bj20041568
Publikováno v:
Cell Calcium. 37:17-24
Alternative splicing of the sarco/endoplasmic reticulum (SERCA2) Ca2+ pump transcript generates the two isoforms: SERCA2a in left ventricular myocytes (LVM) and SERCA2b in most tissues. Nuclear protein extracts from left ventricular myocytes can caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b25ed2fb39b5ca58a667e2e94a148d3e
https://doi.org/10.1016/j.ceca.2004.06.003
https://doi.org/10.1016/j.ceca.2004.06.003
Autor:
Christine M. Misquitta, Tomas Babak, Timothy P. Hughes, Qun Pan, Naveed Mohammad, Quaid Morris, Ofer Shai, Arneet L. Saltzman, Brendan J. Frey, Henry Siu, Wen Zhang, Benjamin J. Blencowe
Publikováno v:
Molecular Cell. 16:929-941
We describe the application of a microarray platform, which combines information from exon body and splice-junction probes, to perform a quantitative analysis of tissue-specific alternative splicing (AS) for thousands of exons in mammalian cells. Thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2bc3eabafc3bcade3386498c890f8f
https://doi.org/10.1016/j.molcel.2004.12.004
https://doi.org/10.1016/j.molcel.2004.12.004
Publikováno v:
Cell Calcium. 35:479-484
Transcripts of the sarco/endoplasmic reticulum Ca2+ pump SERCA2 are alternatively spliced to produce SERCA2a (expressed in left ventricular muscle (LVM)) and SERCA2b (in stomach smooth muscle (SSM)) mRNA that use different polyadenylation sequences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ccbc62b0ee607a042f4e476342f0978
https://doi.org/10.1016/j.ceca.2003.12.001
https://doi.org/10.1016/j.ceca.2003.12.001
Publikováno v:
Molecular and Cellular Biochemistry. 224:53-67
Knowledge of transcription and translation has advanced our understanding of cardiac diseases. Here, we present the hypothesis that the stability of mRNA mediated by the 3′-untranslated region (3′-UTR) plays a role in changing gene expression in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85e36da66088fa46a19d09c305a811b1
https://doi.org/10.1023/a:1011982932645
https://doi.org/10.1023/a:1011982932645
Publikováno v:
Molecular and Cellular Biochemistry. 203:11-15
Endothelium from rat aorta expresses sarco/endoplasmic reticulum Ca2+(SERCA) pump gene SERCA3 where as the smooth muscle expresses SERCA2. This has led to the postulate that vascular endothelium expresses SERCA3. To test this postulate, we examined t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c462fb27c88db5aff9154139391fa994
https://doi.org/10.1023/a:1007093516593
https://doi.org/10.1023/a:1007093516593