Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Christine M. Minnar"'
Autor:
Craig P. Collins, Lam T. Khuat, Gail D. Sckisel, Logan V. Vick, Christine M. Minnar, Cordelia Dunai, Catherine T. Le, Brendan D. Curti, Marka Crittenden, Alexander Merleev, Michael Sheng, Nelson J. Chao, Emanual Maverakis, Spencer R. Rosario, Arta M. Monjazeb, Bruce R. Blazar, Dan L. Longo, Robert J. Canter, William J. Murphy
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The thymus is the central organ involved with T-cell development and the production of naïve T cells. During normal aging, the thymus undergoes marked involution, reducing naïve T-cell output and resulting in a predominance of long-lived memory T c
Externí odkaz:
https://doaj.org/article/1e288536df9248b1a327800dd3a6007e
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
The clinical success of immune checkpoint inhibitors (ICIs) has demonstrated the promise and challenges of cancer immunotherapy. There is an unmet need to develop novel cancer therapies that can provide clinical benefit for most patients with solid m
Externí odkaz:
https://doaj.org/article/e8fbab143a674dc7a197a8a86991489d
Autor:
Kristin C. Hicks, Paul L. Chariou, Yohei Ozawa, Christine M. Minnar, Karin M. Knudson, Thomas J. Meyer, Jing Bian, Margaret Cam, Jeffrey Schlom, Sofia R. Gameiro
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
The immunocytokine NHS-IL12 is targeted to necrotic tumour areas to prompt an immune response. Authors show here in mouse colon and breast models that the combination of histone deacetylase inhibitor, Entinostat, and NHS-IL12 generates a tumour micro
Externí odkaz:
https://doaj.org/article/9ae4f4dff32d41159c913dd23783fab3
Publikováno v:
Cells, Vol 12, Iss 12, p 1611 (2023)
Identifying effective immunotherapies for solid tumors remains challenging despite the significant clinical responses observed in subsets of patients treated with immune checkpoint inhibitors. Interleukin-15 (IL-15) is a promising cytokine for the tr
Externí odkaz:
https://doaj.org/article/38d6cf2bc422492bae553bc26b933434
Autor:
Yohei Ozawa, Kristin C. Hicks, Christine M. Minnar, Karin M. Knudson, Jeffrey Schlom, Sofia R. Gameiro
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Most monoclonal antibodies (MAbs), including immune checkpoint inhibitor MAbs, are delivered intravenously (i.v.) to patients. Recent clinical studies have demonstrated that some anti-PD1 MAbs may also be delivered subcutaneously (s.c.), with clinica
Externí odkaz:
https://doaj.org/article/50767b5a22ba444eb449605c918b8780
Autor:
Gail D. Sckisel, Annie Mirsoian, Christine M. Minnar, Marka Crittenden, Brendan Curti, Jane Q. Chen, Bruce R. Blazar, Alexander D. Borowsky, Arta M. Monjazeb, William J. Murphy
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 5, Iss 1, Pp 1-11 (2017)
Abstract Background Studies assessing immune parameters typically utilize human PBMCs or murine splenocytes to generate data that is interpreted as representative of immune status. Using splenocytes, we have shown memory CD4-T cells that expand follo
Externí odkaz:
https://doaj.org/article/aa73a2ef07044da8b5b7a4a2e4a5bdc2
Autor:
Christine M Minnar, Paul L Chariou, Lucas A Horn, Kristin C Hicks, Claudia Palena, Jeffrey Schlom, Sofia R Gameiro
Publikováno v:
Journal for immunotherapy of cancer. 10(6)
BackgroundImmune checkpoint blockade (ICB) has achieved unprecedented success in treating multiple cancer types. However, clinical benefit remains modest for most patients with solid malignancies due to primary or acquired resistance. Tumor-intrinsic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051377cbeba44f4fd34e2c9e519eac5d
https://pubmed.ncbi.nlm.nih.gov/35764364
https://pubmed.ncbi.nlm.nih.gov/35764364
Autor:
Karin M. Knudson, Yohei Ozawa, Sofia R. Gameiro, Christine M. Minnar, Jeffrey Schlom, Kristin C. Hicks
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Oncoimmunology
article-version (VoR) Version of Record
Oncoimmunology
article-version (VoR) Version of Record
Most monoclonal antibodies (MAbs), including immune checkpoint inhibitor MAbs, are delivered intravenously (i.v.) to patients. Recent clinical studies have demonstrated that some anti-PD1 MAbs may also be delivered subcutaneously (s.c.), with clinica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e49a7c7b8ec1481986c5c1ea22a98a46
https://pubmed.ncbi.nlm.nih.gov/33996267
https://pubmed.ncbi.nlm.nih.gov/33996267
Autor:
Christine M. Minnar, Logan V Vick, Arta M. Monjazeb, Cordelia Dunai, William J. Murphy, Lam T. Khuat, Ziming Wang
Publikováno v:
Cancers, vol 13, iss 4
Cancers
Volume 13
Issue 4
Cancers, Vol 13, Iss 729, p 729 (2021)
Cancers
Volume 13
Issue 4
Cancers, Vol 13, Iss 729, p 729 (2021)
Simple Summary Immune checkpoint inhibition has revolutionized clinical cancer care. As clinical use of these inhibitors increases, the ability to study the effects of these therapies in preclinical models becomes more important. This study highlight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64eaeb2a8eea220e718a43f49f1f8b7d
https://escholarship.org/uc/item/2779286q
https://escholarship.org/uc/item/2779286q
Autor:
Thomas S. Griffith, Raid Aljumaily, Christine M. Minnar, Robert B. Rebhun, Ziming Wang, Sami Ibrahimi, Alexander A. Merleev, Karen Kelly, Emanual Michael Maverakis, Steven K. Grossenbacher, Dan L. Longo, Ian R. Sturgill, William J. Murphy, Cordelia Dunai, Catherine T. Le, Dennis J. Hartigan-O'Connor, Lam T. Khuat, Sara K. Vesely, Ethan G. Aguilar, Bruce R. Blazar, Robert J. Canter, Kevin Stoffel, Annie Mirsoian, Sarbajit Mukherjee, Jesus I. Luna, Kurt A. Schalper, Alice F. Tarantal, Arta M. Monjazeb, Roslyn Rivkah Isseroff, Gema Méndez-Lagares, Sita S. Withers, Asim Saha, Michael Machiorlatti
Publikováno v:
Nature Medicine. 25:141-151
The recent successes of immunotherapy have shifted the paradigm in cancer treatment, but because only a percentage of patients are responsive to immunotherapy, it is imperative to identify factors impacting outcome. Obesity is reaching pandemic propo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34760490f22ca816d2c386561379d71c
https://doi.org/10.1038/s41591-018-0221-5
https://doi.org/10.1038/s41591-018-0221-5