Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Christine M. Jewell"'
Autor:
John A. Cidlowski, Robert H Oakley, Carl D Bortner, Maria Grazia Petrillo, Christine M Jewell
Publikováno v:
Journal of the Endocrine Society
Glucocorticoids are indispensable for mediating the response to stress, energy demands, development, and limiting inflammation. Once in the cell, these hormones exert their actions by activating nuclear receptors, transcription factors that regulate
Publikováno v:
Journal of the Endocrine Society
Adrenal corticosteroids, such as glucocorticoids and mineralocorticoids, are indispensable for mediating response to stress, development, limiting inflammation, and maintaining energy and fluid homeostasis. These hormones exert their actions via bind
Autor:
Kevin S Katen, John A. Cidlowski, Christine M. Jewell, Crystal Cannon, Lisa M. Barber, Stavros Garantziotis
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 311:E741-E748
The glucocorticoid receptor single-nucleotide polymorphism (SNP) N363S has been reported to be associated with metabolic syndrome, type 2 diabetes, and cardiovascular disease. Our aim was to determine how the N363S SNP modifies glucocorticoid recepto
Autor:
Christine M. Jewell, Kevin S Katen, Wei Yue, Daniel F. Heitjan, Hershel Raff, Richard J. Santen, John A. Cidlowski
Background The glucocorticoid receptor (GR) consists of two alternatively spliced isoforms: GRα, which activates gene transcription, and GRβ, a dominant-negative receptor. Theoretically, inactivating variants of GRβ could result in glucocorticoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f145863c1a62d1e828ae577d215600a
https://europepmc.org/articles/PMC6179182/
https://europepmc.org/articles/PMC6179182/
Autor:
John A. Cidlowski, Andrea F. Moon, Christine M. Jewell, Lalith Perera, Lars C. Pedersen, Juno M. Krahn, Jungki Min
Publikováno v:
Molecular and cellular biology. 38(8)
Glucocorticoid receptor β (GRβ) is associated with glucocorticoid resistance via dominant negative regulation of GRα. To better understand how GRβ functions as a dominant negative inhibitor of GRα at a molecular level, we determined the crystal
Autor:
Shannon Whirledge, Lisa M. Barber, John A. Cidlowski, Xiaojiang Xu, Christine M. Jewell, Kevin S Katen, Stavros Garantziotis
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 97(11)
Alternative splicing of the human glucocorticoid receptor gene generates two isoforms, hGRα and hGRβ. hGRβ functions as a dominant-negative regulator of hGRα activity and but also has inherent transcriptional activity, collectively altering gluco
Autor:
Christine M. Jewell, Nick Z. Lu, Ingrid K. Bender, John A. Cidlowski, Yun Cao, Soon Cheon Shin, Athanasios K. Konstantinidis, Robert P. Schleimer
Publikováno v:
Blood. 121:1553-1562
Although glucocorticoids are a profoundly important class of anti-inflammatory and immunosuppressive agents, their actions in dendritic cells (DCs) are not well understood. We found that dexamethasone, a potent glucocorticoid, selectively induced apo
Autor:
John A. Cidlowski, Christine M. Jewell
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 92:3268-3277
A single-nucleotide polymorphism (SNP) in the human glucocorticoid receptor (hGR) N363S (rs6195) has been the focus of several clinical studies, and some epidemiological data link this SNP to increased glucocorticoid sensitivity, coronary artery dise
Autor:
Jennifer B. Collins, John A. Cidlowski, Rachelle J. Bienstock, Laura J. Lewis-Tuffin, Christine M. Jewell
Publikováno v:
Molecular and Cellular Biology. 27:2266-2282
Human glucocorticoid receptor (hGR) is expressed as two alternately spliced C-terminal isoforms, alpha and beta. In contrast to the canonical hGRalpha, hGRbeta is a nucleus-localized orphan receptor thought not to bind ligand and not to affect gene t
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 102:11-21
Glucocorticoids regulate diverse physiological effects in virtually every organ and tissue in the body. Glucocorticoid actions are mediated through the glucocorticoid receptor (GR), a ligand-dependent transcriptional factor that activates or represse