Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Christine M. Hoeman"'
Autor:
Christine M. Hoeman, Francisco J. Cordero, Guo Hu, Katie Misuraca, Megan M. Romero, Herminio J. Cardona, Javad Nazarian, Rintaro Hashizume, Roger McLendon, Paul Yu, Daniele Procissi, Samantha Gadd, Oren J. Becher
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
ACVR1 and H3.1K27M mutations co-occur in diffuse intrinsic pontine glioma. Here, the authors generate a mouse model that recapitulates these genetic lesions and show, using genetic and pharmacological approaches, that the bone morphogenetic protein p
Externí odkaz:
https://doaj.org/article/00a70d4e9ad84bf1a869249303aa2d30
Autor:
Yusuke Tomita, Yosuke Shimazu, Agila Somasundaram, Yoshihiro Tanaka, Nozomu Takata, Yukitomo Ishi, Samantha Gadd, Rintaro Hashizume, Angelo Angione, Gonzalo Pinero, Dolores Hambardzumyan, Daniel J. Brat, Christine M. Hoeman, Oren J. Becher
Publikováno v:
Glia. 70(9)
Diffuse midline glioma (DMG) is a type of lethal brain tumor that develops mainly in children. The majority of DMG harbor the K27M mutation in histone H3. Oligodendrocyte progenitor cells (OPCs) in the brainstem are candidate cells-of-origin for DMG,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab5b04bfbb78f2c27f99f734d378705
https://pubmed.ncbi.nlm.nih.gov/35524725
https://pubmed.ncbi.nlm.nih.gov/35524725
Autor:
Christine M. Hoeman, Tobechukwu K. Ukah, Mindy M. Miller, Alexis N. Cattin-Roy, Subhasis Barik, Habib Zaghouani
Publikováno v:
J Immunol
Early life immune responses are deficient in Th1 lymphocytes that compromise neonatal vaccination. We found that IL-4 and IL-13 engage a developmentally expressed IL-4Rα/IL-13Rα1 heteroreceptor to endow IFN regulatory factor 1 (IRF-1) with apoptoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3284cf92c9ae01505e91feb8f7ee34d
https://doi.org/10.4049/jimmunol.1800943
https://doi.org/10.4049/jimmunol.1800943
Autor:
Javad Nazarian, Guo Hu, Herminio J. Cardona, Daniele Procissi, Paul B. Yu, Rintaro Hashizume, Roger E. McLendon, Megan M. Romero, Samantha Gadd, Oren J. Becher, Katie Misuraca, Francisco Cordero, Christine M. Hoeman
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Diffuse intrinsic pontine glioma (DIPG) is an incurable pediatric brain tumor, with approximately 25% of DIPGs harboring activating ACVR1 mutations that commonly co-associate with H3.1K27M mutations. Here we show that in vitro expression of ACVR1 R20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2274ec625a2b0cdb24f93d5f1d7e8f3e
http://europepmc.org/articles/PMC6399349
http://europepmc.org/articles/PMC6399349
Publikováno v:
Frontiers in Oncology, Vol 8 (2018)
Frontiers in Oncology
Frontiers in Oncology
Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brain tumors, whereby the standard of care is focal radiation, a treatment that provides temporary relief for most patients. Surprisingly, decades of clinical trials have failed to ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10d725ec1e8fa80e79dad2e6aea36430
https://doi.org/10.3389/fonc.2018.00191
https://doi.org/10.3389/fonc.2018.00191
Autor:
Sanja Pajovic, Sameer Agnihotri, David Zagzag, Louis Letourneau, Julia V Hegert, Juliette Hukin, Cynthia Hawkins, King Ching Ho, Mathieu Bourgey, Chris Jones, Annie Huang, Jason E. Cain, Anne Bendel, Yevgen Chornenkyy, Joshua Mangerel, Pedro Castelo-Branco, Andrew Morrison, Mark M. Souweidane, Jean Michaud, Amy Smith, Eric Bouffet, C. David Allis, Matthias A. Karajannis, Lucy Lafay-Cousin, Alexandre Montpetit, David A. Ramsay, Shayna Zelcer, Mark Barszczyk, Cameron Brennan, Chris Dunham, Alan Mackay, Guillaume Bourque, Javad Nazarian, Peter W. Lewis, Ute Bartels, Oren J. Becher, Misko Dzamba, Katrin Scheinemann, Kathryn R. Taylor, Scott Ryall, Jennifer Zuccaro, Nicholas K. Foreman, Pawel Buczkowicz, Michael Brudno, Christine M. Hoeman, Patricia Rakopoulos, Uri Tabori, Jennifer A. Chan, Sandra E. Dunn, Andrew M. Donson, Jason Fangusaro, Francisco Cordero
Publikováno v:
Nature Genetics. 46:451-456
Diffuse intrinsic pontine glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children, with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06d8a59eb0cc0bbe9564eba9dcd77168
https://doi.org/10.1038/ng.2936
https://doi.org/10.1038/ng.2936
Autor:
Mindy M. Miller, Adam A. Zaghouani, John C. Hardaway, Jason A. Cascio, Linda M. Rowland, Fatma Betul Guloglu, Michael P. Sherman, Xiaoxiao Wan, Christine M. Hoeman, Mermagya Dhakal, Habib Zaghouani
Publikováno v:
European Journal of Immunology. 44:842-855
In this study, we examined the role IL-13 receptor alpha 1 (IL-13Rα1) plays in macrophage differentiation and function. The findings indicate that IL-13Rα1 is expressed on the M2 but not on the M1 subset of macrophages and specifically heterodimeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9859b9f54882438d78a2019a1d8e4dae
https://doi.org/10.1002/eji.201343755
https://doi.org/10.1002/eji.201343755
Publikováno v:
Pediatric Research. 75:205-209
Diffuse intrinsic pontine glioma (DIPG) is a high-grade glioma that originates in the pons and is seen exclusively in children. Despite numerous efforts to improve treatment, DIPG remains incurable with 90% of children dying within 2 y of diagnosis,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b720c217153fd3f25478ac80e97c8f6a
https://doi.org/10.1038/pr.2013.194
https://doi.org/10.1038/pr.2013.194
Autor:
Jason A. Cascio, Jason S. Ellis, Mermagya Dhakal, Xiaoxiao Wan, Christine M. Hoeman, F. Betul Guloglu, Habib Zaghouani
Publikováno v:
The Journal of Immunology. 191:1126-1135
The events controlling the transition of T cells from effector to memory remain largely undefined. Many models have been put forth to account for the origin of memory precursors, but for CD4 T cells initial studies reported that memory T cells derive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a854202190919510780cf06596db369d
https://doi.org/10.4049/jimmunol.1202262
https://doi.org/10.4049/jimmunol.1202262
Autor:
Xiaoxiao Wan, Christine M. Hoeman, Sarah Zaghouani, Amie M. VanMorlan, Jason A. Cascio, Mermagya Dhakal, F. Betul Guloglu, Habib Zaghouani, Linda M. Rowland
Publikováno v:
Diabetes
Immune modulation of pancreatic inflammation induces recovery from type 1 diabetes (T1D), but remission was not durable, perhaps because of an inability to sustain the formation and function of new pancreatic β-cells. We have previously shown that I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b828b9be3754de96e28ab429e0a7a9ef
https://doi.org/10.2337/db12-1281
https://doi.org/10.2337/db12-1281