Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Christine M. Gillen"'
Autor:
Joshua Osowicki, Kristy I. Azzopardi, Liam McIntyre, Tania Rivera-Hernandez, Cheryl-lynn Y. Ong, Ciara Baker, Christine M. Gillen, Mark J. Walker, Pierre R. Smeesters, Mark R. Davies, Andrew C. Steer
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
ABSTRACT Group A Streptococcus (GAS) is a major cause of global infection-related morbidity and mortality. A modern controlled human infection model (CHIM) of GAS pharyngitis can accelerate vaccine development and pathogenesis research. A robust rati
Externí odkaz:
https://doaj.org/article/f9d2f88500d34fb29810c3141be9b1b6
Autor:
Tania Rivera-Hernandez, Manisha Pandey, Anna Henningham, Jason Cole, Biswa Choudhury, Amanda J. Cork, Christine M. Gillen, Khairunnisa Abdul Ghaffar, Nicholas P. West, Guido Silvestri, Michael F. Good, Peter M. Moyle, Istvan Toth, Victor Nizet, Michael R. Batzloff, Mark J. Walker
Publikováno v:
mBio, Vol 7, Iss 3 (2016)
ABSTRACT Group A Streptococcus (GAS) is an important human pathogen responsible for both superficial infections and invasive diseases. Autoimmune sequelae may occur upon repeated infection. For this reason, development of a vaccine against GAS repres
Externí odkaz:
https://doaj.org/article/6eb3820b05004e5d845301d5b1d30b90
Autor:
Andrew G. Turner, Cheryl-lynn Y. Ong, Christine M. Gillen, Mark R. Davies, Nicholas P. West, Alastair G. McEwan, Mark J. Walker
Publikováno v:
mBio, Vol 6, Iss 2 (2015)
ABSTRACT Streptococcus pyogenes (group A Streptococcus [GAS]) is an obligate human pathogen responsible for a spectrum of human disease states. Metallobiology of human pathogens is revealing the fundamental role of metals in both nutritional immunity
Externí odkaz:
https://doaj.org/article/c94bf085fa44439ea2d69609cf53a656
Autor:
Bostjan Kobe, Victor J. Torres, Adrienne W. Paton, Thomas Haselhorst, James C. Paton, Josephine F. Reijneveld, Arun V. Everest-Dass, Kristina M. Boguslawski, David B. A. James, Victor Nizet, Michael P. Jennings, Mark von Itzstein, Stephan Brouwer, John M. Atack, Christine M. Gillen, Zhenyao Luo, Lucy K. Shewell, Freda E.-C. Jen, Mark J. Walker, Christopher J. Day
Publikováno v:
Science Advances
Eight major CDCs use glycans as cellular receptors to potentiate cytotoxicity and bind glycans and cholesterol independently.
Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but cholesterol alone is insufficient
Cholesterol-dependent cytolysins (CDCs) form pores in cholesterol-rich membranes, but cholesterol alone is insufficient
Autor:
Kristy Azzopardi, Ciara A Baker, Andrew C Steer, Christine M. Gillen, Mark J. Walker, Pierre R. Smeesters, Mark R. Davies, Joshua Osowicki, Cheryl-lynn Y. Ong, Liam McIntyre, Tania Rivera-Hernandez
Publikováno v:
mSphere, Vol 4, Iss 1, p e00647-18 (2019)
mSphere, 4 (1
mSphere, Vol 4, Iss 1 (2019)
mSphere, 4 (1
mSphere, Vol 4, Iss 1 (2019)
Group A Streptococcus (GAS) is a major cause of global infection-related morbidity and mortality. A modern controlled human infection model (CHIM) of GAS pharyngitis can accelerate vaccine development and pathogenesis research. A robust rationale for
Autor:
Steffen Bernecker, Rolf Jansen, Rolf Müller, Christine M. Gillen, Torsten G. Loof, Katharina Rox, Gursharan S. Chhatwal, Mark J. Walker
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
In contrast to mild infections of Group A Streptococcus (GAS) invasive infections of GAS still pose a serious health hazard: GAS disseminates from sterile sites into the blood stream or deep tissues and causes sepsis or necrotizing fasciitis. In this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb7e7777d1c237fe7e2c96ab7332eac
https://hdl.handle.net/10033/621136
https://hdl.handle.net/10033/621136
Autor:
Jason D. McArthur, Victor Nizet, Timothy C. Barnett, Jason N. Cole, Martina L. Sanderson-Smith, Anna Henningham, Kadaba S. Sriprakash, Christine M. Gillen, Mark J. Walker
Publikováno v:
Clinical Microbiology Reviews. 27:264-301
SUMMARY Streptococcus pyogenes , also known as group A Streptococcus (GAS), causes mild human infections such as pharyngitis and impetigo and serious infections such as necrotizing fasciitis and streptococcal toxic shock syndrome. Furthermore, repeat
Autor:
Andrew J. Barnes, Panagiotis Chrysanthopoulos, Christine M. Gillen, Candice Heath, Mark J. Walker
Publikováno v:
Veterinary microbiology. 193
Streptococcus iniae causes septicaemia and meningitis in marine and freshwater fish wherever they are farmed in warm-temperate and tropical regions. Although serotype specific, vaccination with bacterins (killed bacterial cultures) is largely success
Publikováno v:
Molecular Microbiology. 86:1052-1062
Streptococcus pyogenes (group A streptococcus, GAS) secretes streptokinase, a potent plasminogen activating protein. Among GAS isolates, streptokinase gene sequences (ska) are polymorphic and can be grouped into two distinct sequence clusters (termed
Autor:
Christine M. Gillen, Anna Henningham, Jason N. Cole, Mark J. Walker, Victor Nizet, William L. Taylor, Dwight R. Johnson, Scott A. Beatson, Joshua K. Kirk, Malak Kotb, Andrew Hollands, Carola Venturini, Edward L. Kaplan, Ramy K. Aziz, Jason D. McArthur, Martina L. Sanderson-Smith, Timothy C. Barnett, Nouri L. Ben Zakour, Amanda J. Cork, Peter G. Maamary
Publikováno v:
The FASEB Journal. 26:4675-4684
The past 50 years has witnessed the emergence of new viral and bacterial pathogens with global effect on human health. The hyperinvasive group A Streptococcus (GAS) M1T1 clone, first detected in the mid-1980s in the United States, has since dissemina