Zobrazeno 1 - 10
of 277
pro vyhledávání: '"Christine M. Gall"'
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 18 (2024)
Context contributes to multiple aspects of human episodic memory including segmentation and retrieval. The present studies tested if, in adult male and female mice, context influences the encoding of odors encountered in a single unsupervised samplin
Externí odkaz:
https://doaj.org/article/354083d0b2264f3d936103e6265d0e59
Autor:
Julie C. Lauterborn, Pietro Scaduto, Conor D. Cox, Anton Schulmann, Gary Lynch, Christine M. Gall, C. Dirk Keene, Agenor Limon
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Synaptic loss may disturb the excitatory to inhibitory balance (E/I ratio) in circuits vulnerable in Alzheimer’s disease (AD). The authors find reduced synaptic levels of PSD-95 and gephyrin and show that individuals with AD exhibit a pro-excitator
Externí odkaz:
https://doaj.org/article/9ddd9408600e45e3b0719fb352948350
Autor:
Aliza A. Le, Julian Quintanilla, Mohammad Amani, Daniele Piomelli, Gary Lynch, Christine M. Gall
Publikováno v:
Neurobiology of Disease, Vol 162, Iss , Pp 105565- (2022)
There is evidence that cannabis use during adolescence leads to memory and cognitive problems in young adulthood but little is known about effects of early life cannabis exposure on synaptic operations that are critical for encoding and organizing in
Externí odkaz:
https://doaj.org/article/f992fbb413a144c6ba177736a2c214ac
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Fragile X syndrome (FXS) is associated with deficits in various types of learning, including those that require the hippocampus. Relatedly, hippocampal long-term potentiation (LTP) is impaired in the Fmr1 knockout (KO) mouse model of FXS. Prior resea
Externí odkaz:
https://doaj.org/article/8b98ca7a28c84cd6bbc9e7b8ec158778
Autor:
Collin B. Merrill, Abdul Basit, Andrea Armirotti, Yousheng Jia, Christine M. Gall, Gary Lynch, Daniele Piomelli
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Our understanding of the physiological and pathological functions of brain lipids is limited by the inability to analyze these molecules at cellular resolution. Here, we present a method that enables the detection of lipids in identified sin
Externí odkaz:
https://doaj.org/article/9f790afc890d4acf944d1f4e0b9ee98f
Publikováno v:
Neurobiology of Disease, Vol 41, Iss 2, Pp 436-444 (2011)
Daily, systemic injections of a positive AMPA-type glutamate receptor modulator (ampakine) have been shown to reduce synaptic plasticity defects in rodent models of aging and early-stage Huntington's disease (HD). Here we report that long-term ampaki
Externí odkaz:
https://doaj.org/article/bd8d2fe0cf1a481f8de35ffef1d30b5d
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 1, Pp 200-207 (2005)
Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels mediate hyperpolarization-activated currents (Ih). In hippocampus, these currents contribute greatly to intrinsic cellular properties and synchronized neuronal activity. The kinetic a
Externí odkaz:
https://doaj.org/article/358cd120eb634017b6b30409002d6f7e
Autor:
Julian Quintanilla, Yousheng Jia, Julie C. Lauterborn, Benedict S. Pruess, Aliza A. Le, Conor D. Cox, Christine M. Gall, Gary Lynch, Benjamin G. Gunn
Publikováno v:
The Journal of Physiology. 600:3865-3896
Despite its evident importance to learning theory and models, the manner in which the lateral perforant path (LPP) transforms signals from entorhinal cortex to hippocampus is not well understood. The present studies measured synaptic responses in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585c750820fb40cdcc13fc870cd12c7a
https://doi.org/10.1113/jp283012
https://doi.org/10.1113/jp283012
Autor:
Michael A. Bemben, Matthew A. Sandoval, Aliza A. Le, Sehoon Won, Vivian N Chau, Julie C. Lauterborn, Salvatore Incontro, Kathy H. Li, Alma L. Burlingame, Katherine W. Roche, Christine M. Gall, Roger A. Nicoll, Javier Diaz-Alonso
Neurodevelopmental disorders are frequently linked to mutations in synaptic organizing molecules. MAM domain containing glycosylphosphatidylinositol anchor 1 and 2 (MDGA1 and MDGA2) are a family of synaptic organizers suggested to play an unusual rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41ca99f368ad139fcfa61e0d6f1fcb49
https://doi.org/10.1101/2023.05.25.542333
https://doi.org/10.1101/2023.05.25.542333
Autor:
Aliza A. Le, Julie C. Lauterborn, Yousheng Jia, Weisheng Wang, Conor D. Cox, Christine M. Gall, Gary Lynch
Publikováno v:
Nature neuroscience, vol 25, iss 2
Nat Neurosci
Nat Neurosci
Multiple studies indicate that adult male rodents perform better than females on spatial problems and have a lower threshold for long-term potentiation (LTP) of hippocampal, CA3-to-CA1 synapses. We report here that in rodents, prepubescent females ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad9dbdb29743e962aa64f1a60b32724
https://doi.org/10.1038/s41593-021-01001-5
https://doi.org/10.1038/s41593-021-01001-5