Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Christine M. Dejea"'
Autor:
Sarah Tomkovich, Raad Z. Gharaibeh, Christine M. Dejea, Jillian L. Pope, Jinmai Jiang, Kathryn Winglee, Josee Gauthier, Rachel C. Newsome, Ye Yang, Anthony A. Fodor, Thomas D. Schmittgen, Cynthia L. Sears, Christian Jobin
Publikováno v:
mSystems, Vol 5, Iss 1 (2020)
ABSTRACT Disrupted interactions between host and intestinal bacteria are implicated in colorectal cancer (CRC) development. However, activities derived from these bacteria and their interplay with the host are unclear. Here, we examine this interplay
Externí odkaz:
https://doaj.org/article/b1088a218e284abdb7be9f27d8e4177e
Autor:
Cynthia L. Sears, Ken S. Lau, Franck Housseau, Robert J. Coffey, Fengyi Wan, Christian Jobin, Seth T. Walk, Robert A. Anders, Martha J. Shrubsole, Karen Carroll, Patricia Simner, Hua Ding, Shaoguang Wu, Xinqun Wu, Cody N. Heiser, Victoria L. Campodónico, Fuad Mohammad, James R. White, John Michel, Sarah Tomkovich, Christine M. Dejea, Courtney Stevens, Madison McMann, Lana Kim, June L. Chan, Ada J. Tam, Jada C. Domingue, Reece J. Knippel, Nicholas O. Markham, Jie Chen, Julia L. Drewes
Supplementary Figure from Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c36d44bf3f5e625f3e60e16ee8e663e
https://doi.org/10.1158/2159-8290.22541276
https://doi.org/10.1158/2159-8290.22541276
Autor:
Cynthia L. Sears, Ken S. Lau, Franck Housseau, Robert J. Coffey, Fengyi Wan, Christian Jobin, Seth T. Walk, Robert A. Anders, Martha J. Shrubsole, Karen Carroll, Patricia Simner, Hua Ding, Shaoguang Wu, Xinqun Wu, Cody N. Heiser, Victoria L. Campodónico, Fuad Mohammad, James R. White, John Michel, Sarah Tomkovich, Christine M. Dejea, Courtney Stevens, Madison McMann, Lana Kim, June L. Chan, Ada J. Tam, Jada C. Domingue, Reece J. Knippel, Nicholas O. Markham, Jie Chen, Julia L. Drewes
Supplementary Table from Human Colon Cancer–Derived Clostridioides difficile Strains Drive Colonic Tumorigenesis in Mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f52ae0bbb8bf1acb1a065acc7498c4
https://doi.org/10.1158/2159-8290.22541270
https://doi.org/10.1158/2159-8290.22541270
Autor:
Cynthia L. Sears, Ken S. Lau, Franck Housseau, Robert J. Coffey, Fengyi Wan, Christian Jobin, Seth T. Walk, Robert A. Anders, Martha J. Shrubsole, Karen Carroll, Patricia Simner, Hua Ding, Shaoguang Wu, Xinqun Wu, Cody N. Heiser, Victoria L. Campodónico, Fuad Mohammad, James R. White, John Michel, Sarah Tomkovich, Christine M. Dejea, Courtney Stevens, Madison McMann, Lana Kim, June L. Chan, Ada J. Tam, Jada C. Domingue, Reece J. Knippel, Nicholas O. Markham, Jie Chen, Julia L. Drewes
Defining the complex role of the microbiome in colorectal cancer and the discovery of novel, protumorigenic microbes are areas of active investigation. In the present study, culturing and reassociation experiments revealed that toxigenic strains of C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75dc57b0b4d711f49b25e207c8a0afb
https://doi.org/10.1158/2159-8290.c.6549596.v1
https://doi.org/10.1158/2159-8290.c.6549596.v1
Autor:
Cynthia L. Sears, Franck Housseau, Heather M. O'Hagan, Stephen B. Baylin, Robert A. Anders, Sepideh Besharati, Angelo M. De Marzo, Hao Wang, Douglas B. Rusch, Ram Podicheti, Shruthi Sriramkumar, Ashley R. Maiuri, John Michel, Hongni Fan, Christine M. Dejea, June L. Chan, Ada J. Tam, Jessica L. Hicks, Alyssa Wenzel, Liam Chung, James R. White, Christina E. DeStefano Shields
Differential methylation values for methylation-binding domain sequencing (MBDseq) for sham and ETBF-colonized normal epithelium and tumors from Min and BRAFV600ELgr5CreMin (BLM) colons.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976abf85227f45ce0ca13bee5c61cfa9
https://doi.org/10.1158/2159-8290.22540270.v1
https://doi.org/10.1158/2159-8290.22540270.v1
Autor:
Cynthia L. Sears, Franck Housseau, Heather M. O'Hagan, Stephen B. Baylin, Robert A. Anders, Sepideh Besharati, Angelo M. De Marzo, Hao Wang, Douglas B. Rusch, Ram Podicheti, Shruthi Sriramkumar, Ashley R. Maiuri, John Michel, Hongni Fan, Christine M. Dejea, June L. Chan, Ada J. Tam, Jessica L. Hicks, Alyssa Wenzel, Liam Chung, James R. White, Christina E. DeStefano Shields
Supplementary Figures 1-6; Table S4: Tumors from ETBF-colonized BRAFV600ELgr5CreMin (BLM) mice are MSI negative; Table S6: Primer sequences for qMSP and assays used for Taqman gene expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836113c42e53c55422cc9c54f512311b
https://doi.org/10.1158/2159-8290.22540276
https://doi.org/10.1158/2159-8290.22540276
Autor:
Cynthia L. Sears, Franck Housseau, Heather M. O'Hagan, Stephen B. Baylin, Robert A. Anders, Sepideh Besharati, Angelo M. De Marzo, Hao Wang, Douglas B. Rusch, Ram Podicheti, Shruthi Sriramkumar, Ashley R. Maiuri, John Michel, Hongni Fan, Christine M. Dejea, June L. Chan, Ada J. Tam, Jessica L. Hicks, Alyssa Wenzel, Liam Chung, James R. White, Christina E. DeStefano Shields
Colorectal cancer is multifaceted, with subtypes defined by genetic, histologic, and immunologic features that are potentially influenced by inflammation, mutagens, and/or microbiota. Colorectal cancers with activating mutations in BRAF are associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a526c0fa8ded8e7a89042195bc05ed
https://doi.org/10.1158/2159-8290.c.6549334
https://doi.org/10.1158/2159-8290.c.6549334
Autor:
June L. Chan, Christine M. Dejea, Shruthi Sriramkumar, Sepideh Besharati, John H. Michel, Hongni Fan, Hao Wang, Alyssa Wenzel, Franck Housseau, Robert A. Anders, Liam Chung, Jessica L. Hicks, Angelo M. De Marzo, Ram Podicheti, Ada J. Tam, Ashley R. Maiuri, James R. White, Stephen B. Baylin, Christina E. DeStefano Shields, Douglas B. Rusch, Heather M. O'Hagan, Cynthia L. Sears
Publikováno v:
Cancer Discovery. 11:1792-1807
Colorectal cancer is multifaceted, with subtypes defined by genetic, histologic, and immunologic features that are potentially influenced by inflammation, mutagens, and/or microbiota. Colorectal cancers with activating mutations in BRAF are associate
Autor:
Julia L. Drewes, Jie Chen, Nicholas O. Markham, Reece J. Knippel, Jada C. Domingue, Ada J. Tam, June L. Chan, Lana Kim, Madison McMann, Courtney Stevens, Christine M. Dejea, Sarah Tomkovich, John Michel, James R. White, Fuad Mohammad, Victoria L. Campodónico, Cody N. Heiser, Xinqun Wu, Shaoguang Wu, Hua Ding, Patricia Simner, Karen Carroll, Martha J. Shrubsole, Robert A. Anders, Seth T. Walk, Christian Jobin, Fengyi Wan, Robert J. Coffey, Franck Housseau, Ken S. Lau, Cynthia L. Sears
Publikováno v:
Cancer discovery. 12(8)
Defining the complex role of the microbiome in colorectal cancer and the discovery of novel, protumorigenic microbes are areas of active investigation. In the present study, culturing and reassociation experiments revealed that toxigenic strains of C
Autor:
Ye Yang, Raad Z. Gharaibeh, Payam Fathi, Shaoguang Wu, Liam Chung, Anthony A. Fodor, Sarah Tomkovich, Sepideh Besharati, Marcus Mühlbauer, James R. White, Jillian L. Pope, Cynthia L. Sears, Ernesto Perez-Chanona, Drew M. Pardoll, Julia L. Drewes, Kathryn Winglee, Xinqun Wu, Robert A. Anders, Christian Jobin, Franck Housseau, Christine M. Dejea, Hao Wang, Xiaolun Sun, Josee Gauthier, Xiuli Liu, Hua Ding
Publikováno v:
Journal of Clinical Investigation. 129:1699-1712
Mucus-invasive bacterial biofilms are identified on the colon mucosa of approximately 50% of colorectal cancer (CRC) patients and approximately 13% of healthy subjects. Here, we test the hypothesis that human colon biofilms comprise microbial communi