Zobrazeno 1 - 10
of 176
pro vyhledávání: '"Christine M Sorenson"'
Autor:
Christine M Sorenson, Zafer Gurel, Yong-Seok Song, Kyle D Peterson, Barbara A Blodi, Nader Sheibani
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297135 (2024)
Age-related macular degeneration (AMD) is a vision threatening disease in older adults. Anti-VEGF treatment is effective for the majority of neovascular AMD (nAMD) patients, although approximately 30% of nAMD patients have an incomplete response for
Externí odkaz:
https://doaj.org/article/aac38f7c859d491182daf612a28022c1
Autor:
Ismail S Zaitoun, Yong-Seok Song, Andrew Suscha, Mohamed El Ragaby, Christine M Sorenson, Nader Sheibani
Publikováno v:
PLoS ONE, Vol 16, Iss 12, p e0260793 (2021)
Retinopathy of prematurity (ROP) is one of the main causes of blindness in children worldwide. Brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB), play critical protective roles in the development and funct
Externí odkaz:
https://doaj.org/article/d43fd94c7bf1461ab5d50e0a7217a8d3
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232779 (2020)
Apoptosis of neurovascular cells, including astroglial cells, contributes to the pathogenesis of diseases in which neurovascular disruption plays a central role. Bim is a pro-apoptotic protein that modulates not only apoptosis but also various cellul
Externí odkaz:
https://doaj.org/article/3cd9e06dd9574727bac8d3e0ab7b0690
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231752 (2020)
Astrocytes (AC) are the most abundant cells in the central nervous system. In the retina, astrocytes play important roles in the development and integrity of the retinal neurovasculature. Astrocytes dysfunction contributes to pathogenesis of a variet
Externí odkaz:
https://doaj.org/article/7a686fd06a2f4804a0a853e170de7db6
Publikováno v:
Journal of Ophthalmic & Vision Research, Vol 13, Iss 4, Pp 470-486 (2018)
Angiogenesis, the formation of new blood vessels from pre-existing capillaries, is very tightly regulated and normally does not occur except during developmental and reparative processes. This tight regulation is maintained by a balanced production o
Externí odkaz:
https://doaj.org/article/8ac234f96c39404ebce6ca2fb407a901
Autor:
Zahra Ghanian, Kevin Staniszewski, Nasim Jamali, Reyhaneh Sepehr, Shoujian Wang, Christine M Sorenson, Nader Sheibani, Mahsa Ranji
Publikováno v:
Journal of Medical Signals and Sensors, Vol 6, Iss 2, Pp 71-80 (2016)
A multi-parameter quantification method was implemented to quantify retinal vascular injuries in microscopic images of clinically relevant eye diseases. This method was applied to wholemount retinal trypsin digest images of diabetic Akita/+, and bcl-
Externí odkaz:
https://doaj.org/article/51afdf257a9d4a2187e21f1198670b31
Autor:
Juliana Falero-Perez, Yong-Seok Song, Yun Zhao, Leandro Teixeira, Christine M Sorenson, Nader Sheibani
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0206756 (2018)
Cytochrome P450 1B1 (CYP1B1) is a member of the cytochrome p450 family of enzymes that catalyze mono-oxygenase reactions. Although constitutive Cyp1b1 expression is limited in hepatocytes, its expression and function in liver sinusoidal endothelial c
Externí odkaz:
https://doaj.org/article/08efa39c0bb848a884b2ca3526a6c74c
Publikováno v:
Journal of Ophthalmic & Vision Research, Vol 10, Iss 1, Pp 60-67 (2015)
Cytochrome P450 1B1 (Cyp1b1) belongs to the CYP450 superfamily of heme-binding mono-oxygenases which catalyze oxidation of various endogenous and exogenous substrates. The expression of Cyp1b1 plays an important role in the modulation of development
Externí odkaz:
https://doaj.org/article/57895cadbf694bcb813a7a726e67efef
Autor:
Shoujian Wang, Ismail S Zaitoun, Ryan P Johnson, Nasim Jamali, Zafer Gurel, Catherine M Wintheiser, Andreas Strasser, Volkhard Lindner, Nader Sheibani, Christine M Sorenson
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178198 (2017)
Apoptosis plays a central role in developmental and pathological angiogenesis and vessel regression. Bim is a pro-apoptotic Bcl-2 family member that plays a prominent role in both developmental and pathological ocular vessel regression, and neovascul
Externí odkaz:
https://doaj.org/article/6d7417dca5314dd4a62f17a51bc601f9
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0190131 (2017)
Vitamin D provides a significant benefit to human health, and its deficiency has been linked to a variety of diseases including cancer. Vitamin D exhibits anticancer effects perhaps through inhibition of angiogenesis. We previously showed that the ac
Externí odkaz:
https://doaj.org/article/de267ce410934cb9ada3b24d9b79fe5b