Allopregnanolone preclinical acute pharmacokinetic and pharmacodynamic studies to predict tolerability and efficacy for Alzheimer's disease.

Autor: Ronald W Irwin, Christine M Solinsky, Carlos M Loya, Francesco G Salituro, Kathleen E Rodgers, Gerhard Bauer, Michael A Rogawski, Roberta Diaz Brinton

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0128313 (2015)

To develop allopregnanolone as a therapeutic for Alzheimer's disease, we investigated multiple formulations and routes of administration in translationally relevant animal models of both sexes. Subcutaneous, topical (transdermal and intranasal), intr

Externí odkaz: https://doaj.org/article/040fc371d0ab4f1ca16b64dd413384d7

Overall Adverse Event Profile of Vadadustat versus Darbepoetin Alfa for the Treatment of Anemia Associated with Chronic Kidney Disease in Phase 3 Trials

Autor: Rajiv Agarwal, Sanjeev Anand, Kai-Uwe Eckardt, Wenli Luo, Patrick S. Parfrey, Mark J. Sarnak, Christine M. Solinsky, Dennis L. Vargo, Wolfgang C. Winkelmayer, Glenn M. Chertow

Publikováno v: American Journal of Nephrology. 53:701-710

Introduction: Anemia frequently occurs in chronic kidney disease (CKD), is associated with poor quality of life and cardiovascular outcomes, and its treatment represents a considerable economic burden to the healthcare system. Although effective, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ae1f880da6d02e2bd5d17d73f397c79
https://doi.org/10.1159/000528443

Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial

Autor: Meng Law, Chun-Yi Wu, Gerhard Bauer, Naoko Kono, Roberta Diaz Brinton, Kathleen E. Rodgers, Sonia Pawluczyk, Michael A. Rogawski, Yonggang Shi, Lon S. Schneider, Gerson D. Hernandez, Wendy J. Mack, Claudia M. Lopez, Christine M. Solinsky, Ana R. Mollo, Dawn C. Matthews

Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 6, Iss 1, Pp n/a-n/a (2020)
Alzheimer's & Dementia : Translational Research & Clinical Interventions
Alzheimer's & dementia (New York, N. Y.), vol 6, iss 1

IntroductionAllopregnanolone is an endogenous neurosteroid with the potential to be a novel regenerative therapeutic for Alzheimer's disease (AD). Foundations of mechanistic understanding and well-established preclinical safety efficacy make it a via

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7a72e1a800aa86cfaff396ae92788c7
https://doi.org/10.1002/trc2.12107

[P3–167]: DEVELOPMENT OF AN IPSC‐BASED BIOMARKER STRATEGY TO IDENTIFY NEUROREGENERATIVE RESPONDERS TO ALLOPREGNANOLONE

Autor: Mathew Blurton-Jones, Christine M. Solinsky, Justin K. Ichida, Roberta Diaz Brinton, Helena C. Chui, Jenny Ayoung Park

Publikováno v: Alzheimer's & Dementia. 13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e667cab6e9490079401c371913f185e
https://doi.org/10.1016/j.jalz.2017.06.1379

P3-032: COMBINING SEX, APOE GENOTYPE, AND MITOCHONDRIAL GENETIC VARIANCE AS PREDICTIVE RESPONDER IDENTIFIER TO REGENERATIVE THERAPEUTIC ALLOPREGNANOLONE FOR ALZHEIMER'S DISEASE

Autor: Lon S. Schneider, Gerson D. Hernandez, Roberta Diaz Brinton, Yiwei Wang, Christine M. Solinsky

Publikováno v: Alzheimer's & Dementia. 15:P938-P938

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::17ed7f9dbc563234f852df38471f7718
https://doi.org/10.1016/j.jalz.2019.06.3058