Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christine M M, Hendriks"'
Autor:
Antonella Minutolo, Christine M. M. Hendriks, Rosalba Pecorari, Danilo Faccenda, Daniela Strobbe, Oriana Conte, Stefan Wiezorek, Rosella Abeti, Carsten Bolm, Michelangelo Campanella, Carla Montesano
Publikováno v:
British Journal of Pharmacology
British journal of pharmacology 178(2), 298-311 (2021). doi:10.1111/bph.15279
British journal of pharmacology 178(2), 298-311 (2021). doi:10.1111/bph.15279
British journal of pharmacology 178(2), 298-311 (2021). doi:10.1111/bph.15279
Published by Wiley, Malden, MA
Published by Wiley, Malden, MA
Autor:
Daniela, Strobbe, Rosalba, Pecorari, Oriana, Conte, Antonella, Minutolo, Christine M M, Hendriks, Stefan, Wiezorek, Danilo, Faccenda, Rosella, Abeti, Carla, Montesano, Carsten, Bolm, Michelangelo, Campanella
Publikováno v:
British journal of pharmacology. 178(2)
The mitochondrial FThe chemical structure of the FNHS selectively blocks the consumption of ATP by mitochondria leading a subtle cytotoxicity associated via the concomitant engagement of autophagy which impairs cell viability. NHS achieves such a fun
Autor:
Trevor M. Penning, Italo A. Sanhueza, Tianzhu Zang, Franziska Schoenebeck, Dominik Wiemuth, Stefan Gründer, Carsten Bolm, Christine M. M. Hendriks
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:4437-4440
Pentafluorosulfanyl-containing analogs of flufenamic acid have been synthesized in high yields. Computationally, pKa, LogP and LogD values have been determined. Initial bioactivity studies reveal effects as ion channel modulators and inhibitory activ
Publikováno v:
Synthesis. 47:1190-1194
Zolimidine is a methylsulfonyl-substituted drug with an imidazo[1,2-α]pyridine core used for the treatment of peptic ulcer. Herein, we report the synthesis of unprecedented N-acetylsulfilimine and -sulfoximine analogues under mild conditions. Depr
Autor:
Giulia Rossetti, Stefan Wiezorek, Christine M. M. Hendriks, Jörg Hartkamp, Anne-Dorothee Steinkamp, Carsten Bolm, Bernhard Lüscher
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(12)
The ATM- and Rad3-related (ATR) kinases play a key role in DNA repair processes and thus ATR is an attractive target for cancer therapy. Here we designed and synthesized sulfilimidoyl- and sulfoximidoyl-substituted analogs of the sulfone VE-821, a re
Publikováno v:
Advanced Synthesis & Catalysis. 356:1847-1852
A general method for the N-alkylation of NH-sulfoximines and NH-sulfondiimines has been developed, employing alkyl bromides with KOH in DMSO at room temperature. A variety of previously inaccessible N-alkylated sulfoximines and sulfondiimines was pre
Publikováno v:
Advanced Synthesis & Catalysis. 355:3363-3368
Sulfoxides can directly be converted into N-cyanosulfilimines using a new Burgess-type reagent. By applying this strategy with a related reagent variant, synthetically valuable NH-sulfoximines have been prepared from sulfoxides via N-protected sulfil
Publikováno v:
Synlett. 26:73-75
A low-cost and high-yielding synthetic route towards methyl 4-pentafluorosulfanylphenyl sulfoximines from the corresponding sulfide has been developed. The intermediate N-cyano sulfoximine was converted into the corresponding N-(1H)-tetrazole, and th
Publikováno v:
ChemInform. 46
Being mono-aza analogues of sulfoxides and sulfones, sulfimides and sulfoximines, respectively, are important compounds in asymmetric synthesis, crop protection and medicinal chemistry. For their preparation various methods have been developed. In th
Publikováno v:
Chemical Society reviews 44(11), 3378-3390 (2015). doi:10.1039/C5CS00208G
Chemical Society reviews 44(11), 3378-3390(2015). doi:10.1039/C5CS00208G
Published by Chemical Society, London
Published by Chemical Society, London
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869b487f34ae306bca512d068906372b
https://publications.rwth-aachen.de/record/565133
https://publications.rwth-aachen.de/record/565133