Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Christine M Grimaldi"'
Autor:
Daisuke Kawabata, Jeganathan Venkatesh, Meera Ramanujam, Anne Davidson, Christine M Grimaldi, Betty Diamond
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8418 (2010)
A major goal for the treatment of patients with systemic lupus erythematosus with cytotoxic therapies is the induction of long-term remission. There is, however, a paucity of information concerning the effects of these therapies on the reconstituting
Externí odkaz:
https://doaj.org/article/58da7bd4436b44b5a446b14125210b1d
Autor:
Christine M. Grimaldi, Prameladevi Chinnasamy, Jeganathan Venkatesh, Joel Cohen-Solal, Anfisa Stanevsky, Hajime Yoshifuji, Betty Diamond, Daisuke Kawabata
Publikováno v:
The Journal of Immunology. 186:5304-5312
Systemic lupus erythematosus is an autoimmune disease characterized by autoantibodies and systemic inflammation that results in part from dendritic cell activation by nucleic acid containing immune complexes. There are many mouse models of lupus, som
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38564abcebd3ea4db884af662c7415b
https://doi.org/10.4049/jimmunol.1000224
https://doi.org/10.4049/jimmunol.1000224
Autor:
Christine M. Grimaldi, Elahna Paul, Sun Jung Kim, Betty Diamond, Daisuke Kawabata, Xiaonan Xu, Jeganathan Venkatesh, Prameladevi Chinnasamy
Publikováno v:
Journal of Autoimmunity. 32:149-157
FcgammaRIIB is an inhibitory receptor which plays a role in limiting B cell and DC activation. Since FcgammaRIIB is known to dampen the signaling strength of the BCR, we wished to determine the impact of FcgammaRIIB on the regulation of BCRs which di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea64c4f3ed9c6d358ea760d8ce6ed4d4
https://doi.org/10.1016/j.jaut.2009.02.009
https://doi.org/10.1016/j.jaut.2009.02.009
Publikováno v:
The Journal of Immunology. 174:1775-1781
Autoreactive B cells arise routinely as part of the naive B cell repertoire. The immune system employs several mechanisms in an attempt to silence these autoreactive cells before they achieve immunocompetence. The BCR plays a central role in B cell d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adc5a973507c3dab7da98511ac46e925
https://doi.org/10.4049/jimmunol.174.4.1775
https://doi.org/10.4049/jimmunol.174.4.1775
Autor:
Meera Ramanujam, Anne Davidson, Michael P. Madaio, Christine M. Grimaldi, Alla Akkerman, Lena Schiffer, Betty Diamond, Xiaobo Wang, Weiqing Huang
Publikováno v:
The Journal of Immunology. 173:3524-3534
B cell-activating factor belonging to the TNF family (BAFF) blockade prevents the onset of disease in systemic lupus erythematosus (SLE)-prone NZB/NZW F1 mice. To determine the mechanism of this effect, we administered a short course of TACI-Ig with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c687083aeccfdaa846915822d79f2c84
https://doi.org/10.4049/jimmunol.173.5.3524
https://doi.org/10.4049/jimmunol.173.5.3524
Publikováno v:
Journal of Clinical Investigation. 106:1373-1379
Estrogen can modulate autoimmunity in certain models of systemic lupus erythematosus. Recently, we have shown that it can mediate survival and activation of anti-DNA B cells in a mouse transgenic for the heavy chain of a pathogenic anti-DNA antibody.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228d08288412cac05cae1d0e5fdeb057
https://doi.org/10.1172/jci10420
https://doi.org/10.1172/jci10420
Autor:
Christine M. Grimaldi, Fangping Chen, Changhong Wu, Harvey J. Weiss, Barry S. Coller, Deborah L. French
Publikováno v:
Blood. 91:1562-1571
Glanzmann thrombasthenia is an inherited bleeding disorder due to a functional reduction or absence of platelet GPIIb/IIIa (αIIbβ3) integrin receptors. Based on a prolonged bleeding time and absence of platelet aggregation in response to physiologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ea7f94b4474cff3cd28d087556b49dd
https://doi.org/10.1182/blood.v91.5.1562.1562_1562_1571
https://doi.org/10.1182/blood.v91.5.1562.1562_1562_1571
Publikováno v:
Blood. 88:1666-1675
A 20-year-old woman from a consanguineous family in the Hunan Province of the People's Republic of China was diagnosed as having Glanzmann's thrombasthenia based on (1) nearly a lifelong history of epistaxis, gum bleeding, petechiae, and purpura; (2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a11049cbd79e96e81d88fdd5973510ea
https://doi.org/10.1182/blood.v88.5.1666.1666
https://doi.org/10.1182/blood.v88.5.1666.1666
Publikováno v:
Blood. 88:1666-1675
A 20-year-old woman from a consanguineous family in the Hunan Province of the People's Republic of China was diagnosed as having Glanzmann's thrombasthenia based on (1) nearly a lifelong history of epistaxis, gum bleeding, petechiae, and purpura; (2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23da66d445064588bf8fffde9da77eef
https://doi.org/10.1182/blood.v88.5.1666.bloodjournal8851666
https://doi.org/10.1182/blood.v88.5.1666.bloodjournal8851666