Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christine M, Wardell"'
Autor:
Justin A. Spanier, Vivian Fung, Christine M. Wardell, Mohannad H. Alkhatib, Yixin Chen, Linnea A. Swanson, Alexander J. Dwyer, Matthew E. Weno, Nubia Silva, Jason S. Mitchell, Paul C. Orban, Majid Mojibian, C. Bruce Verchere, Brian T. Fife, Megan K. Levings
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Adoptive immunotherapy with Tregs is a promising approach for preventing or treating type 1 diabetes. Islet antigen–specific Tregs have more potent therapeutic effects than polyclonal cells, but their low frequency is a barrier for clinical applica
Externí odkaz:
https://doaj.org/article/07b12edb27a645e0ba884c7c896ee39b
Autor:
Joshua Choi, Crystal L Schmerk, Tina S Mele, Patrick T Rudak, Christine M Wardell, Gansen Deng, Farzan R Pavri, Kyoungok Kim, Gediminas Cepinskas, Wenqing He, SM Mansour Haeryfar
Publikováno v:
Immunology & Cell Biology. 101:249-261
Sepsis-elicited immunosuppression elevates the risk of secondary infections. We used a clinically relevant mouse model and serial peripheral blood samples from patients to assess the antimicrobial activities of mucosa-associated invariant T (MAIT) ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211364bd8dca1eafbddbea2b1d94ce76
https://doi.org/10.1111/imcb.12619
https://doi.org/10.1111/imcb.12619
Autor:
Justin A. Spanier, Vivian Fung, Christine M. Wardell, Mohannad H. Alkhatib, Yixin Chen, Linnea A. Swanson, Alexander J. Dwyer, Matthew E. Weno, Nubia Silva, Jason S. Mitchell, Paul C. Orban, Majid Mojibian, C. Bruce Verchere, Brian T. Fife, Megan K. Levings
Publikováno v:
bioRxiv
Adoptive immunotherapy with Tregs is a promising approach for prevention or treatment of type 1 diabetes. Islet antigen-specific Tregs have more potent therapeutic effects than polyclonal cells, but their low frequency is a barrier for clinical appli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8adb046184699296d252da99ef8993a5
https://europepmc.org/articles/PMC9980092/
https://europepmc.org/articles/PMC9980092/
Autor:
Rasheduzzaman Rashu, Marina Ninkov, Christine M. Wardell, Jenna M. Benoit, Nicole I. Wang, Michael R. D’Agostino, Ali Zhang, Emily Feng, Nasrin Saeedian, Gillian I. Bell, Fatemeh Vahedi, David A. Hess, Ryan M. Troyer, C. Yong Kang, Ali A. Ashkar, Matthew S. Miller, S.M. Mansour Haeryfar
Mucosa-associated invariant T (MAIT) cells are MR1-restricted, innate-like T lymphocytes with tremendous antibacterial and immunomodulatory functions. MAIT cells also sense and respond to viral infections in an MR1-independent fashion. However, wheth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76ef1632fdad598c015fc1588121bf8d
https://doi.org/10.1101/2023.02.20.529311
https://doi.org/10.1101/2023.02.20.529311
Autor:
Caigan Du, Haiming D. Luo, Megan K. Levings, Christine M. Wardell, Kevin Rey, Jayachandran N. Kizhakkedathu, Lyann Sim, Jonathan C. Choy, Qiunong Guan, Stephen G. Withers, Zheng J. Zhang, Franklin Tam, Mahdis Monajemi, Haisle Moon, Majid Mojibian, Ashani Montgomery, Erika M. J. Siren, Winnie Enns, Jiao Jing Wang
Publikováno v:
Nature Biomedical Engineering. 5:1202-1216
Systemic immunosuppression for the mitigation of immune rejection after organ transplantation causes adverse side effects and constrains the long-term benefits of the transplanted graft. Here we show that protecting the endothelial glycocalyx in vasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2175031ed608ed2b3119774c537262b
https://doi.org/10.1038/s41551-021-00777-y
https://doi.org/10.1038/s41551-021-00777-y
Autor:
null Avery J. Lam, null Manjurul Haque, null Kirsten A. Ward‐Hartstonge, null Prakruti Uday, null Christine M. Wardell, null Jana K. Gillies, null Madeleine Speck, null Majid Mojibian, null Ramon I. Klein Geltink, null Megan K. Levings
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a00435ed284e5b2b8fed5fdb5a48a5
https://doi.org/10.1002/eji.202249888/v3/response1
https://doi.org/10.1002/eji.202249888/v3/response1
Publikováno v:
European Journal of Immunology. 51:27-38
Regulatory T cells (Tregs) have a critical role in maintaining self-tolerance and immune homeostasis. There is much interest in using Tregs as a cell therapy to re-establish tolerance in conditions such as inflammatory bowel disease and type 1 diabet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def3d5e9629c790b330b322542501bdb
https://doi.org/10.1002/eji.202048746
https://doi.org/10.1002/eji.202048746
Autor:
Avery J. Lam, Manjurul Haque, Kirsten A. Ward-Hartstonge, Prakruti Uday, Christine M. Wardell, Jana K. Gillies, Madeleine Speck, Majid Mojibian, Ramon I. Klein Geltink, Megan K. Levings
Regulatory T cell (Treg) therapy is under clinical investigation for the treatment of transplant rejection, autoimmune disease, and graft-versus-host disease. With the advent of genome editing, attention has turned to reinforcing Treg function for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e13a459671c19adc4b4ca6174f8cf63
https://doi.org/10.1101/2022.03.06.483188
https://doi.org/10.1101/2022.03.06.483188
Autor:
Christine M. Wardell, Megan K. Levings
Publikováno v:
Nature Biotechnology. 39:419-421
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2a4513f68e10c315d4f38d58a1bf25a
https://doi.org/10.1038/s41587-021-00880-0
https://doi.org/10.1038/s41587-021-00880-0
Autor:
Erika M J, Siren, Haiming D, Luo, Franklin, Tam, Ashani, Montgomery, Winnie, Enns, Haisle, Moon, Lyann, Sim, Kevin, Rey, Qiunong, Guan, Jiao-Jing, Wang, Christine M, Wardell, Mahdis, Monajemi, Majid, Mojibian, Megan K, Levings, Zheng J, Zhang, Caigan, Du, Stephen G, Withers, Jonathan C, Choy, Jayachandran N, Kizhakkedathu
Publikováno v:
Nature biomedical engineering. 5(10)
Systemic immunosuppression for the mitigation of immune rejection after organ transplantation causes adverse side effects and constrains the long-term benefits of the transplanted graft. Here we show that protecting the endothelial glycocalyx in vasc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fb072dc105ab07b80f5440822410952d
https://pubmed.ncbi.nlm.nih.gov/34373602
https://pubmed.ncbi.nlm.nih.gov/34373602