Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Christine M, Roberts"'
Autor:
Thomas J. LaRocca, Alyssa N. Cavalier, Christine M. Roberts, Maddie R. Lemieux, Pooja Ramesh, Micklaus A. Garcia, Christopher D. Link
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105493- (2021)
The amyloid beta (Aβ) peptide is believed to play a central role in Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. However, the natural, evolutionarily selected functions of Aβ are incompletely understood. Here, w
Externí odkaz:
https://doaj.org/article/0434b43faf314aa190e7a45eaee064e2
Autor:
Carl Julien, Colson Tomberlin, Christine M. Roberts, Aumbreen Akram, Gretchen H. Stein, Michael A. Silverman, Christopher D. Link
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Abstract Exposure to the β-amyloid peptide (Aβ) is toxic to neurons and other cell types, but the mechanism(s) involved are still unresolved. Synthetic Aβ oligomers can induce ion-permeable pores in synthetic membranes, but whether this ability to
Externí odkaz:
https://doaj.org/article/1f49f07c11c7449ba8ea25f9610c027e
Autor:
Patrick K Gonzales, Christine M Roberts, Virginia Fonte, Connor Jacobsen, Gretchen H Stein, Christopher D Link
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194581 (2018)
Trisomy of chromosome 21, the genetic cause of Down syndrome, has the potential to alter expression of genes on chromosome 21, as well as other locations throughout the genome. These transcriptome changes are likely to underlie the Down syndrome clin
Externí odkaz:
https://doaj.org/article/be75117366c54bd1925dec0a1348fa56
Autor:
Christopher D. Link, Virginia Fonte, Christine M. Roberts, Brian Hiester, Michael A. Silverman, Gretchen H. Stein
Publikováno v:
Neurobiology of Disease, Vol 32, Iss 3, Pp 420-425 (2008)
Although there is compelling evidence that the β amyloid peptide (Aβ) can be centrally involved in Alzheimer's disease, the natural role (if any) of this peptide remains unclear. Here we use green fluorescent protein (GFP) fusions to demonstrate th
Externí odkaz:
https://doaj.org/article/afa479fa29814cb1bfebc9d87cff4917
Autor:
Christine M. Roberts, Alyssa N. Cavalier, Thomas J. LaRocca, Christopher D. Link, Maddie R. Lemieux
SUMMARYThe amyloid beta (Aβ) peptide is believed to play a central role in Alzheimer’s disease (AD), the most common age-related neurodegenerative disorder. However, the natural, evolutionarily-selected functions of Aβ are incompletely understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::551d7609f6d8c767a231bdde4d8dd9f2
https://doi.org/10.1101/2020.09.28.316927
https://doi.org/10.1101/2020.09.28.316927
Autor:
Christopher D. Link, Alyssa N. Cavalier, Maddie R. Lemieux, Pooja Ramesh, Micklaus A. Garcia, Thomas J. LaRocca, Christine M. Roberts
Publikováno v:
Neurobiology of disease
Neurobiology of Disease, Vol 159, Iss, Pp 105493-(2021)
Neurobiology of Disease, Vol 159, Iss, Pp 105493-(2021)
The amyloid beta (Aβ) peptide is believed to play a central role in Alzheimer's disease (AD), the most common age-related neurodegenerative disorder. However, the natural, evolutionarily selected functions of Aβ are incompletely understood. Here, w
Autor:
Nicole R. Cunningham, Susanna H. Hoffman, Victoria F. D’Acunto, Christopher D. Link, F. Jay Garcia, Jennifer Hofmann, Christine M. Roberts, Nabeel M. Akhtar, Robert Fairman, Surin A. Kim, Seema H. Doshi, Kathleen M. Ulrich, Thomas M. Laue, Bashkim Kokona, Emily M. Bistline, Nicholas M. Jones, Nancy M. Bonini
Publikováno v:
Biochemistry. 56:4676-4688
At least nine neurodegenerative diseases that are caused by the aggregation induced by long tracts of glutamine sequences have been identified. One such polyglutamine-containing protein is huntingtin, which is the primary factor responsible for Hunti
Autor:
Christopher D. Link, Colson Tomberlin, Gretchen H. Stein, Michael A. Silverman, Aumbreen Akram, Carl Julien, Christine M. Roberts
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-16 (2018)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Exposure to the β-amyloid peptide (Aβ) is toxic to neurons and other cell types, but the mechanism(s) involved are still unresolved. Synthetic Aβ oligomers can induce ion-permeable pores in synthetic membranes, but whether this ability to damage m
Autor:
Carrie A. May, Nicole R. Cunningham, Kathleen M. Ulrich, Christopher D. Link, Julia C. Durante, Christine M. Roberts, Robert Fairman, Thomas M. Laue, Lynn Richmond, Bashkim Kokona, Walter F. Stafford, F. Jay Garcia
Publikováno v:
Protein Science. 25:605-617
This work explores the heterogeneity of aggregation of polyglutamine fusion constructs in crude extracts of transgenic Caenorhabditis elegans animals. The work takes advantage of the recent technical advances in fluorescence detection for the analyti
Autor:
Christine M. Roberts, Leonard Petrucelli, Alfonso Garrido-Lecca, Tassa K Saldi, Vishantie Dostal, Patrick K. Gonzales, Christopher D. Link
Publikováno v:
Molecular and Cellular Biology
TDP-1 is the Caenorhabditis elegans ortholog of mammalian TDP-43, which is strongly implicated in the etiology of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). We discovered that deletion of the tdp-1 gene results in enhanced