Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Christine M, Parseghian"'
Autor:
Ignacio I Wistuba, Andrew Futreal, Xuemei Wang, Arvind Dasari, Cathy Eng, Scott Kopetz, Edwin R Parra, Cara L Haymaker, Eduardo Vilar, Robert A Wolff, Kanwal Raghav, Michael J Overman, Younghee Lee, Benny Johnson, Luisa Maren Solis Soto, Jane V Thomas, Van K Morris, Bryan K Kee, Christine M Parseghian, Daniele Lorenzini, Caddie Laberiano-Fernandez, Anuj Verma, Wenhua Lang
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 8 (2022)
Background Monotherapy with immune checkpoint blockade is ineffective for patients (pts) with microsatellite stable (MSS) metastatic colorectal cancer (mCRC). This study investigates whether the combination of trametinib (T) with durvalumab (D) can a
Externí odkaz:
https://doaj.org/article/df046ec2d0ff48c99275fc303b6ac56b
Autor:
Van K. Morris, Michael J. Overman, Michael Lam, Christine M. Parseghian, Benny Johnson, Arvind Dasari, Kanwal Raghav, Bryan K. Kee, Ryan Huey, Robert A. Wolff, John Paul Shen, June Li, Isabel Zorrilla, Ching-Wei D. Tzeng, Hop S. Tran Cao, Yun Shin Chun, Timothy E. Newhook, Nicolas Vauthey, Dzifa Duose, Raja Luthra, Cara Haymaker, Scott Kopetz
Publikováno v:
Cancer Res Commun
Identification of circulating tumor DNA (ctDNA) following curative intent therapies is a surrogate for microscopic residual disease for patients with metastatic colorectal cancer (mCRC). Preclinically, in micrometastatic microsatellite stable (MSS) c
Autor:
Scott Kopetz, Cara Haymaker, Raja Luthra, Dzifa Duose, Nicolas Vauthey, Timothy E. Newhook, Yun Shin Chun, Hop S. Tran Cao, Ching-Wei D. Tzeng, Isabel Zorrilla, June Li, John Paul Shen, Robert A. Wolff, Ryan Huey, Bryan K. Kee, Kanwal Raghav, Arvind Dasari, Benny Johnson, Christine M. Parseghian, Michael Lam, Michael J. Overman, Van K. Morris
Supplemental Figure S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23047c1c7af615af907aa9b1ff30b2be
https://doi.org/10.1158/2767-9764.22545027
https://doi.org/10.1158/2767-9764.22545027
Autor:
Scott Kopetz, Cara Haymaker, Raja Luthra, Dzifa Duose, Nicolas Vauthey, Timothy E. Newhook, Yun Shin Chun, Hop S. Tran Cao, Ching-Wei D. Tzeng, Isabel Zorrilla, June Li, John Paul Shen, Robert A. Wolff, Ryan Huey, Bryan K. Kee, Kanwal Raghav, Arvind Dasari, Benny Johnson, Christine M. Parseghian, Michael Lam, Michael J. Overman, Van K. Morris
Supplemental Table S3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45bfafcb5bba1d4f82234d718a8d7a1f
https://doi.org/10.1158/2767-9764.22545018
https://doi.org/10.1158/2767-9764.22545018
Autor:
Scott Kopetz, Cara Haymaker, Raja Luthra, Dzifa Duose, Nicolas Vauthey, Timothy E. Newhook, Yun Shin Chun, Hop S. Tran Cao, Ching-Wei D. Tzeng, Isabel Zorrilla, June Li, John Paul Shen, Robert A. Wolff, Ryan Huey, Bryan K. Kee, Kanwal Raghav, Arvind Dasari, Benny Johnson, Christine M. Parseghian, Michael Lam, Michael J. Overman, Van K. Morris
Identification of circulating tumor DNA (ctDNA) following curative intent therapies is a surrogate for microscopic residual disease for patients with metastatic colorectal cancer (mCRC). Preclinically, in micrometastatic microsatellite stable (MSS) c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e4434852d47d4560f312c44fd8c7a0
https://doi.org/10.1158/2767-9764.c.6550830
https://doi.org/10.1158/2767-9764.c.6550830
Autor:
Scott Kopetz, Gary E. Gallick, Alain R. Thierry, Michael J. Overman, Cathy Eng, Robert A. Wolff, David G. Menter, Anastasia D. Katsiampoura, David R. Fogelman, Arvind Dasari, Kanwal Raghav, Marc Ychou, Brice Pastor, Feng Tian, Laura Henderson, Zhi-Qin Jiang, Ji Yuan Wu, Nila U. Parikh, Christine M. Parseghian
Purpose: Aberrant activation of the intracellular tyrosine kinase Src has been implicated as a mechanism of acquired chemotherapy resistance in metastatic colorectal cancer (mCRC). Here, the oral tyrosine kinase Src inhibitor, dasatinib, was investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493cba9094cd2e6c43821d133756c6a5
https://doi.org/10.1158/1078-0432.c.6526826
https://doi.org/10.1158/1078-0432.c.6526826
Autor:
Scott Kopetz, Gary E. Gallick, Alain R. Thierry, Michael J. Overman, Cathy Eng, Robert A. Wolff, David G. Menter, Anastasia D. Katsiampoura, David R. Fogelman, Arvind Dasari, Kanwal Raghav, Marc Ychou, Brice Pastor, Feng Tian, Laura Henderson, Zhi-Qin Jiang, Ji Yuan Wu, Nila U. Parikh, Christine M. Parseghian
Validation of peripheral blood mononuclear cells as a biomarker of Src inhibition. Freshly collected peripheral blood mononuclear cells from a healthy volunteer were treated ex-vivo with dasatinib 300 nM or hydrogen peroxide 0.05 mM. The peripheral b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42048aa738ec1b6e17d9bcc70397504b
https://doi.org/10.1158/1078-0432.22468073
https://doi.org/10.1158/1078-0432.22468073
Autor:
Scott Kopetz, Gary E. Gallick, Alain R. Thierry, Michael J. Overman, Cathy Eng, Robert A. Wolff, David G. Menter, Anastasia D. Katsiampoura, David R. Fogelman, Arvind Dasari, Kanwal Raghav, Marc Ychou, Brice Pastor, Feng Tian, Laura Henderson, Zhi-Qin Jiang, Ji Yuan Wu, Nila U. Parikh, Christine M. Parseghian
Operating characteristics. A summary of the probability of stopping the trial early for the indicated true response rates.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e1507020a7c8559fc408126becd09af
https://doi.org/10.1158/1078-0432.22468061
https://doi.org/10.1158/1078-0432.22468061
Autor:
Scott Kopetz, Gary E. Gallick, Alain R. Thierry, Michael J. Overman, Cathy Eng, Robert A. Wolff, David G. Menter, Anastasia D. Katsiampoura, David R. Fogelman, Arvind Dasari, Kanwal Raghav, Marc Ychou, Brice Pastor, Feng Tian, Laura Henderson, Zhi-Qin Jiang, Ji Yuan Wu, Nila U. Parikh, Christine M. Parseghian
Supplemental material
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39aa0ab58191ff5a8d7e882c49b26d1e
https://doi.org/10.1158/1078-0432.22468064.v1
https://doi.org/10.1158/1078-0432.22468064.v1
Autor:
Scott Kopetz, Gary E. Gallick, Alain R. Thierry, Michael J. Overman, Cathy Eng, Robert A. Wolff, David G. Menter, Anastasia D. Katsiampoura, David R. Fogelman, Arvind Dasari, Kanwal Raghav, Marc Ychou, Brice Pastor, Feng Tian, Laura Henderson, Zhi-Qin Jiang, Ji Yuan Wu, Nila U. Parikh, Christine M. Parseghian
Lack of correlation between Src activity in PBMCs and hepatic tumors. For the patients in the expansion cohort, the change in the expression of pSrc and total Src was not correlated with a change in the phosphorlyation of the Src substrate paxillin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5672206e4a57e3878ce7df721ab8dd75
https://doi.org/10.1158/1078-0432.22468070
https://doi.org/10.1158/1078-0432.22468070