Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Christine M, Grinnell"'
Autor:
Philip D. Bardwell, Matthew M. Staron, Junjian Liu, Qingfeng Tao, Susanne Scesney, Gail Bukofzer, Luis E. Rodriguez, Chee-Ho Choi, Jennifer Wang, Qing Chang, Feng Dong, Cherrie Donawho, Jieyi Wang, Christine M. Grinnell, Edit Tarcsa, Charles Hutchins, Tariq Ghayur, Jijie Gu
Publikováno v:
Protein & Cell, Vol 9, Iss 1, Pp 121-129 (2017)
Abstract Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antig
Externí odkaz:
https://doaj.org/article/7d9af6e5d86246a79205f69880a28694
Autor:
Qian Zhang, Kedar S. Vaidya, Christine M Grinnell, Mark G. Anderson, Anatol Oleksijew, Sasmita Mishra, Lora A. Tucker, Jieyi Wang, Joann P. Palma, William N. Pappano, Erwin R. Boghaert, Sarah J Heighton, Michael J. Mitten, Edward B. Reilly
Publikováno v:
Pharmacology. 100:229-242
ABT-700 is a therapeutic antibody against the hepatocyte growth factor receptor (MET). At doses or regimens that lead to exposures exceeding optimum in vivo, the efficacy of ABT-700 is unexpectedly reduced. We hypothesized that this reduction in effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4821f90c152e3a7f2a8b8b712d3964
https://doi.org/10.1159/000478663
https://doi.org/10.1159/000478663
Autor:
Steve, McGaraughty, Rachel A, Davis-Taber, Chang Z, Zhu, Todd B, Cole, Arthur L, Nikkel, Meha, Chhaya, Kelly J, Doyle, Lauren M, Olson, Gregory M, Preston, Christine M, Grinnell, Katherine M, Salte, Anthony M, Giamis, Yanping, Luo, Victor, Sun, Andrew D, Goodearl, Murali, Gopalakrishnan, Susan E, Lacy
Publikováno v:
Journal of the American Society of Nephrology : JASN. 28(12)
Targeted delivery of a therapeutic agent to a site of pathology to ameliorate disease while limiting exposure at undesired tissues is an aspirational treatment scenario. Targeting diseased kidneys for pharmacologic treatment has had limited success.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6aeb256d7adad1311bfdd617d18c9741
https://pubmed.ncbi.nlm.nih.gov/28827403
https://pubmed.ncbi.nlm.nih.gov/28827403