Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Christine M, Fennessey"'
Autor:
Taina T. Immonen, Christine M. Fennessey, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, Nora Waltz, Gregory Q. Del Prete, Jeffrey D. Lifson, Brandon F. Keele
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The capacity of HIV-1 to replicate during optimal antiretroviral therapy (ART) is challenging to assess directly. To gain greater sensitivity to detect evolution on ART, we used a nonhuman primate (NHP) model providing precise control over t
Externí odkaz:
https://doaj.org/article/a0716cb015224205a4ae6dfb6adb219b
Autor:
Benjamin Varco-Merth, Morgan Chaunzwa, Derick M Duell, Alejandra Marenco, William Goodwin, Rachel Dannay, Michael Nekorchuk, Danica Shao, Kathleen Busman-Sahay, Christine M Fennessey, Lorna Silipino, Michael Hull, William J Bosche, Randy Fast, Kelli Oswald, Rebecca Shoemaker, Rachele Bochart, Rhonda MacAllister, Caralyn S Labriola, Jeremy V Smedley, Michael K Axthelm, Miles P Davenport, Paul T Edlefsen, Jacob D Estes, Brandon F Keele, Jeffrey D Lifson, Sharon R Lewin, Louis J Picker, Afam A Okoye
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012496 (2024)
Persistence of the rebound-competent viral reservoir (RCVR) within the CD4+ T cell compartment of people living with HIV remains a major barrier to HIV cure. Here, we determined the effects of the pan-lymphocyte-depleting monoclonal antibody (mAb) al
Externí odkaz:
https://doaj.org/article/98aa0bf5a0db40c1870449c56d1dca1f
Autor:
Jinhee Kim, Deepanwita Bose, Mariluz Araínga, Muhammad R. Haque, Christine M. Fennessey, Rachel A. Caddell, Yanique Thomas, Douglas E. Ferrell, Syed Ali, Emanuelle Grody, Yogesh Goyal, Claudia Cicala, James Arthos, Brandon F. Keele, Monica Vaccari, Ramon Lorenzo-Redondo, Thomas J. Hope, Francois Villinger, Elena Martinelli
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract HIV-1 persistence during ART is due to the establishment of long-lived viral reservoirs in resting immune cells. Using an NHP model of barcoded SIVmac239 intravenous infection and therapeutic dosing of anti-TGFBR1 inhibitor galunisertib (LY2
Externí odkaz:
https://doaj.org/article/fbe3b5ac6da84f6e995899f2ef2ce0bd
Autor:
Jinhee Kim, Deepanwita Bose, Mariluz Araínga, Muhammad R. Haque, Christine M. Fennessey, Rachel A. Caddell, Yanique Thomas, Douglas E. Ferrell, Syed Ali, Emanuelle Grody, Yogesh Goyal, Claudia Cicala, James Arthos, Brandon F. Keele, Monica Vaccari, Ramon Lorenzo-Redondo, Thomas J. Hope, Francois Villinger, Elena Martinelli
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/d4eafc33aa964eaaa8d6b74d7af7c6e2
Autor:
Brandon F. Keele, Afam A. Okoye, Christine M. Fennessey, Benjamin Varco-Merth, Taina T. Immonen, Emek Kose, Andrew Conchas, Mykola Pinkevych, Leslie Lipkey, Laura Newman, Agatha Macairan, Marjorie Bosche, William J. Bosche, Brian Berkemeier, Randy Fast, Mike Hull, Kelli Oswald, Rebecca Shoemaker, Lorna Silipino, Robert J. Gorelick, Derick Duell, Alejandra Marenco, William Brantley, Jeremy Smedley, Michael Axthelm, Miles P. Davenport, Jeffrey D. Lifson, Louis J. Picker
Publikováno v:
PLoS Pathogens, Vol 20, Iss 4 (2024)
Externí odkaz:
https://doaj.org/article/df5e85a50a9043c2bca569ca53f3f088
Autor:
Michael W Grunst, Hwi Min Gil, Andres G Grandea, Brian J Snow, Raiees Andrabi, Rebecca Nedellec, Iszac Burton, Natasha M Clark, Sanath Kumar Janaka, Nida K Keles, Ryan V Moriarty, Andrea M Weiler, Saverio Capuano, Christine M Fennessey, Thomas C Friedrich, Shelby L O'Connor, David H O'Connor, Aimee T Broman, Brandon F Keele, Jeffrey D Lifson, Lars Hangartner, Dennis R Burton, David T Evans
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011819 (2024)
Fc-mediated antibody effector functions, such as antibody-dependent cellular cytotoxicity (ADCC), can contribute to the containment HIV-1 replication but whether such activities are sufficient for protection is unclear. We previously identified an an
Externí odkaz:
https://doaj.org/article/8f8b7d273bab487cb298ce773438920f
Autor:
Mykola Pinkevych, Steffen S Docken, Afam A Okoye, Christine M Fennessey, Gregory Q Del Prete, Maria Pino, Justin L Harper, Michael R Betts, Mirko Paiardini, Brandon F Keele, Miles P Davenport
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011660 (2023)
One approach to 'functional cure' of HIV infection is to induce durable control of HIV replication after the interruption of antiretroviral therapy (ART). However, the major factors that determine the viral 'setpoint' level after treatment interrupti
Externí odkaz:
https://doaj.org/article/3ae2558a10c74188bef570d4a345b7f7
Autor:
Rachele M Bochart, Kathleen Busman-Sahay, Stephen Bondoc, David W Morrow, Alexandra M Ortiz, Christine M Fennessey, Miranda B Fischer, Oriene Shiel, Tonya Swanson, Christine M Shriver-Munsch, Hugh B Crank, Kimberly M Armantrout, Aaron M Barber-Axthelm, Charlotte Langner, Cassandra R Moats, Caralyn S Labriola, Rhonda MacAllister, Michael K Axthelm, Jason M Brenchley, Brandon F Keele, Jacob D Estes, Scott G Hansen, Jeremy V Smedley
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011343 (2023)
[This corrects the article DOI: 10.1371/journal.ppat.1009565.].
Externí odkaz:
https://doaj.org/article/642da0372b874e13b89429f1a824dff1
Autor:
Alexandra M. Ortiz, Phillip J. Baker, Charlotte A. Langner, Jennifer Simpson, Apollo Stacy, Jacob K. Flynn, Carly E. Starke, Carol L. Vinton, Christine M. Fennessey, Yasmine Belkaid, Brandon F. Keele, Jason M. Brenchley
Publikováno v:
Cell Reports, Vol 42, Iss 1, Pp 112020- (2023)
Summary: Variations in the composition of the intestinal bacterial microbiome correlate with acquisition of some sexually transmitted pathogens. To experimentally assess the contribution of intestinal dysbiosis to rectal lentiviral acquisition, we in
Externí odkaz:
https://doaj.org/article/7081ddf554cf4942b21ea596c9eb27a3
Autor:
Scott P Lawrence, Samra E Elser, Workineh Torben, Robert V Blair, Bapi Pahar, Pyone P Aye, Faith Schiro, Dawn Szeltner, Lara A Doyle-Meyers, Beth S Haggarty, Andrea P O Jordan, Josephine Romano, George J Leslie, Xavier Alvarez, David H O'Connor, Roger W Wiseman, Christine M Fennessey, Yuan Li, Michael Piatak, Jeffrey D Lifson, Celia C LaBranche, Andrew A Lackner, Brandon F Keele, Nicholas J Maness, Mark Marsh, James A Hoxie
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010507 (2022)
The HIV/SIV envelope glycoprotein (Env) cytoplasmic domain contains a highly conserved Tyr-based trafficking signal that mediates both clathrin-dependent endocytosis and polarized sorting. Despite extensive analysis, the role of these functions in vi
Externí odkaz:
https://doaj.org/article/d548a853acc4469fa6a4e1326a82b9a7