Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice

Autor: Franz Marxreiter, Benjamin Ettle, Verena E.L. May, Hakan Esmer, Christina Patrick, Christine Lund Kragh, Jochen Klucken, Beate Winner, Olaf Riess, Jürgen Winkler, Eliezer Masliah, Silke Nuber

Publikováno v: Neurobiology of Disease, Vol 59, Iss , Pp 38-51 (2013)

In Parkinson's disease (PD) patients, alpha-synuclein (α-syn) pathology advances in form of Lewy bodies and Lewy neurites throughout the brain. Clinically, PD is defined by motor symptoms that are predominantly attributed to the dopaminergic cell lo

Externí odkaz: https://doaj.org/article/c105eda5863c4e4fa290d16245e9edf4

Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice

Autor: Benjamin Ettle, Eliezer Masliah, Christina Patrick, Jürgen Winkler, Beate Winner, Christine Lund Kragh, Jochen Klucken, Silke Nuber, Franz Marxreiter, Hakan Esmer, Olaf Riess, Verena E.L. May

Publikováno v: Neurobiology of Disease, Vol 59, Iss, Pp 38-51 (2013)

In Parkinson's disease (PD) patients, alpha-synuclein (α-syn) pathology advances in form of Lewy bodies and Lewy neurites throughout the brain. Clinically, PD is defined by motor symptoms that are predominantly attributed to the dopaminergic cell lo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eeca52861c4b12b20af23cb2ad98b1d
https://doi.org/10.1016/j.nbd.2013.07.004

Detection of elevated levels of soluble -synuclein oligomers in post-mortem brain extracts from patients with dementia with Lewy bodies

Autor: Christine Lund Kragh, David M. A. Mann, Omar M. A. El-Agnaf, Sultan A. Salem, David Allsop, Rania Al-Shami, Poul Henning Jensen, Katerina E. Paleologou, Ahmed H. Hassan

Publikováno v: Brain. 132:1093-1101

A number of neurodegenerative diseases including Parkinson's disease, dementia with Lewy bodies (DLB) and multiple system atrophy are characterized by the formation and intraneuronal accumulation of fibrillar aggregates of alpha-synuclein (alpha-syn)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72f63e964a4da621f9f7a10b7ba3048
https://doi.org/10.1093/brain/awn349

FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy

Autor: Manuela Neumann, Glenda M. Halliday, Hanne D. Hansen, Wei Ping Gai, Christiane Richter-Landsberg, Christian Haass, Christine Lund Kragh, Catherine Lubetzki, Amanda M. Gysbers, Poul Henning Jensen, Bernard Zalc, Gwenaelle Fillon, Philipp J. Kahle

Publikováno v: PLOS ONE 8(1), e55243 (2013). doi:10.1371/journal.pone.0055243
PLoS ONE, Vol 8, Iss 1, p e55243 (2013)
PLoS ONE; Vol 8
Kragh, C L, Fillon, G, Gysbers, A, Hansen, H D, Neumann, M, Richter-Landsberg, C, Haass, C, Zalc, B, Lubetzki, C, Gai, W-P, Halliday, G M, Kahle, P J & Jensen, P H 2013, ' FAS-Dependent Cell Death in α-Synuclein Transgenic Oligodendrocyte Models of Multiple System Atrophy ', P L o S One, vol. 8, no. 1, pp. e55243 . https://doi.org/10.1371/journal.pone.0055243
PLoS ONE
PLoS ONE, Public Library of Science, 2013, 8 (1), ⟨10.1371/journal.pone.0055243⟩

Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3eec5b7d30bcecf6ed2099bbeac7e31
https://pub.dzne.de/record/136805