Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Christine LoSardo"'
Autor:
Deborah Galinis, Sheila J. Miknyoczki, Ted L. Underiner, Damaris Rolon-Steele, Jean Husten, Craig A. Zificsak, Thelma S. Angeles, Torsten Herbertz, Mark S. Albom, Bruce D. Dorsey, Laura S. Kocsis, Kevin J. Wells-Knecht, Jay P. Theroff, Lisa D. Aimone, Kelli S. Zeigler, Candace S. Worrell, Rebecca A. Brown, Christine LoSardo, Seetha Murthy, Jennifer Grobelny
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:660-663
Elaboration of the SAR around a series of 2,4-diaminopyrimidines led to a number of c-Met inhibitors in which kinase selectivity was modulated by substituents appended on the C4-aminobenzamide ring and the nature of the C2-aminoaryl ring. Further lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd2f5ede7c3bb696001314f924df06f4
https://doi.org/10.1016/j.bmcl.2010.12.013
https://doi.org/10.1016/j.bmcl.2010.12.013
Autor:
Hong Chang, Jean Husten, Lisa D. Aimone, Thelma S. Angeles, Christine LoSardo, Karen L. Milkiewicz, Damaris Rolon-Steele, Seetha Murthy, Mark S. Albom, Jennifer Grobelny, Candace S. Worrell, Ted L. Underiner, Linda Weinberg, Bruce D. Dorsey, Kelli S. Zeigler, Sheila J. Miknyoczki
Publikováno v:
Bioorganicmedicinal chemistry. 19(21)
The hepatocyte growth factor (HGF)-c-Met signaling axis is involved in the mediation of many biological activities, including angiogenesis, proliferation, cell survival, cell motility, and morphogenesis. Dysregulation of c-Met signaling (e.g., overex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97e067c0d3b0becbb7b3228b634d8dc1
https://pubmed.ncbi.nlm.nih.gov/21967808
https://pubmed.ncbi.nlm.nih.gov/21967808