Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Christine Light"'
Autor:
Karthickeyan Chella Krishnan, Elie-Julien El Hachem, Mark P Keller, Sanjeet G Patel, Luke Carroll, Alexis Diaz Vegas, Isabela Gerdes Gyuricza, Christine Light, Yang Cao, Calvin Pan, Karolina Elżbieta Kaczor-Urbanowicz, Varun Shravah, Diana Anum, Matteo Pellegrini, Chi Fung Lee, Marcus M Seldin, Nadia A Rosenthal, Gary A Churchill, Alan D Attie, Benjamin Parker, David E James, Aldons J Lusis
Publikováno v:
eLife, Vol 12 (2023)
Mitochondria play an important role in both normal heart function and disease etiology. We report analysis of common genetic variations contributing to mitochondrial and heart functions using an integrative proteomics approach in a panel of inbred mo
Externí odkaz:
https://doaj.org/article/2a1b6fe7048b41d5bd20badbfb9d149f
Autor:
Angela Simms, Martin J. Whiting, J. Sean Doody, Jusri Nilawati, Fadly Y. Tantu, Andrew Walde, Fatmah Lauhido, Christine Light, Mirza Kusrini, Amir Hamidy, Andrew P. Allen, Simon Clulow
Publikováno v:
Journal of Herpetology. 56
Autor:
Karthickeyan Chella Krishnan, Elie-Julien El Hachem, Luke Carroll, Alexis Diaz Vegas, Christine Light, Yang Cao, Calvin Pan, Karolina Elżbieta Kaczor-Urbanowicz, Varun Shravah, Diana Anum, Matteo Pellegrini, Chi Fung Lee, Marcus M. Seldin, Benjamin L. Parker, David E. James, Aldons J. Lusis
Mitochondria play a key role in the normal function of the heart as well as in the pathogenesis of diseases. We report analysis of common genetic variations contributing to mitochondrial and heart functions using an integrative proteomics approach in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df82170eafc4189e576805e2df62f2bc
https://doi.org/10.1101/2022.08.24.505177
https://doi.org/10.1101/2022.08.24.505177
Publikováno v:
Circulation Research. 131
Diabetes is a risk factor for heart disease. NAD depletion has emerged as a hallmark of cardiometabolic diseases, and hence, elevating NAD level alleviates diabetic cardiomyopathy. On the other hand, inhibition of NAD consumption also maintains NAD h
Publikováno v:
Circulation Research. 131
Heart failure occurs at twice the rate in diabetic patients compared to normal subjects. NAD redox imbalance or depletion has emerged as a hallmark of diabetes and heart disease. We showed that NAD redox imbalance or depletion promotes heart failure
Publikováno v:
The FASEB Journal. 36
Autor:
Christine Light, Chi Fung Lee
Publikováno v:
Circulation. 144
Introduction: NAD depletion emerges as a hallmark of diseases. Strategies to replenish NAD levels have shown promise to treat heart disease, including heart failure with preserved ejection fraction (HFpEF). However, how NAD consumption mechanisms lea
Autor:
Christine Light, Chi Fung Lee
Publikováno v:
Circulation Research. 129
NAD depletion is associated with the pathogenesis of diseases such as heart failure. Strategies to replenish cellular NAD levels by activating NAD synthesis pathways have shown promises to treat heart disease. However, how NAD consumption mechanisms
Abstract MP252: Genetic Architecture Of Heart Mitochondrial Proteome Influencing Cardiac Hypertrophy
Autor:
Aldons J. Lusis, Benjamin L. Parker, Karthickeyan Chella Krishnan, Chi Fung Lee, Elie-Julien El Hachem, Varun Shravah, Christine Light, David E. James, Diana C. Anum, Marcus M. Seldin
Publikováno v:
Circulation Research. 129
Our lab studies how natural genetic variations affect common diseases using a mouse population called hybrid mouse diversity panel (HMDP). In this study, we have explored the genetic regulation of mitochondrial pathways and their contribution to hear
Autor:
Junichi Sadoshima, Akash Deep Chakraborty, Chi Fung Lee, Rong Tian, Haiwei Gu, Christine Light, Xiaojian Shi, Ying Ann Chiao
Publikováno v:
Circulation: Heart Failure. 14
Background: Diabetes is a risk factor for heart failure and promotes cardiac dysfunction. Diabetic tissues are associated with nicotinamide adenine dinucleotide (NAD + ) redox imbalance; however, the hypothesis that NAD + redox imbalance causes diabe