Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin

Autor: Ralf J. Braun, Cornelia Sommer, Christine Leibiger, Romina J.G. Gentier, Verónica I. Dumit, Katrin Paduch, Tobias Eisenberg, Lukas Habernig, Gert Trausinger, Christoph Magnes, Thomas Pieber, Frank Sinner, Jörn Dengjel, Fred W. van Leeuwen, Guido Kroemer, Frank Madeo

Publikováno v: Cell Reports, Vol 10, Iss 9, Pp 1557-1571 (2015)

Neuronal accumulation of UBB+1, a frameshift variant of ubiquitin B, is a hallmark of Alzheimer’s disease (AD). How UBB+1 contributes to neuronal dysfunction remains elusive. Here, we show that in brain regions of AD patients with neurofibrillary t

Externí odkaz: https://doaj.org/article/82827895d6f54a068f30299b67cf92a1

TDP-43 controls lysosomal pathways thereby determining its own clearance and cytotoxicity

Autor: Maria Tereshchenko, Stefanie Ambros, Bert M. Verheijen, Sabrina Büttner, Christine Leibiger, Ralf J. Braun, Jana Deisel, Andreas Aufschnaiter

Publikováno v: Microbial Cell

The accumulation of protein aggregates in neurons is a typical pathological hallmark of the motor neuron disease amyotrophic lateral sclerosis (ALS) and of frontotemporal dementia (FTD). In many cases, these aggregates are composed of the 43 kDa TAR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2494dd30b09c187e0798b698524e153
https://doi.org/10.1093/hmg/ddy066

Accumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant Ubiquitin

Autor: Katrin Paduch, Verónica I. Dumit, Guido Kroemer, Tobias Eisenberg, Frank Madeo, Fred W. van Leeuwen, Frank Sinner, Gert Trausinger, Lukas Habernig, Thomas R. Pieber, Christine Leibiger, Christoph Magnes, Jörn Dengjel, Cornelia Sommer, Romina J.G. Gentier, Ralf J. Braun

Publikováno v: Cell Reports
Microbial Cell
Microbial Cell, Vol 2, Iss 4, Pp 136-138 (2015)
Cell Reports, 10(9), 1557-1571. Cell Press
Cell Reports, Vol 10, Iss 9, Pp 1557-1571 (2015)

Summary Neuronal accumulation of UBB+1, a frameshift variant of ubiquitin B, is a hallmark of Alzheimer’s disease (AD). How UBB+1 contributes to neuronal dysfunction remains elusive. Here, we show that in brain regions of AD patients with neurofibr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afcf3e83bd6a03c974fa1c26c7674b01

First molecular cytogenetic high resolution characterization of the NIH 3T3 cell line by murine multicolor banding

Autor: Michael Glei, Hasmik Mkrtchyan, Thomas Liehr, Christine Leibiger, Nadezda Kosyakova, Vladimir A. Trifonov

Publikováno v: Journal of Histochemistry and Cytochemistry

Since being established in 1963, the murine fibroblast cell line NIH 3T3 has been used in thousands of studies. NIH 3T3 immortalized spontaneously and became tetraploid shortly after its establishment. Here we report the first molecular cytogenetic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::821b5b69e416d46cd6d0fee07222232b
https://pubmed.ncbi.nlm.nih.gov/23321776