Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Christine Lehner"'
Autor:
Christine Lehner, Gabriel Spitzer, Patrick Langthaler, Dominika Jakubecova, Barbara Klein, Nadja Weissenbacher, Andrea Wagner, Renate Gehwolf, Eugen Trinka, Bernhard Iglseder, Bernhard Paulweber, Ludwig Aigner, Sebastien Couillard-Després, Richard Weiss, Herbert Tempfer, Andreas Traweger
Publikováno v:
EBioMedicine, Vol 75, Iss , Pp 103778- (2022)
Summary: Background: Treatment of degenerating tendons still presents a major challenge, since the aetiology of tendinopathies remains poorly understood. Besides mechanical overuse, further known predisposing factors include rheumatoid arthritis, dia
Externí odkaz:
https://doaj.org/article/a9a60de349324be0abf71be6980c04b1
Autor:
Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 12 (2019)
Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined. Therefore, the aim o
Externí odkaz:
https://doaj.org/article/b02b385b39c0478e89e7877679d4b070
Autor:
Herbert Tempfer, Alexandra Kaser-Eichberger, Christine Lehner, Renate Gehwolf, Stefanie Korntner, Nadja Kunkel, Andrea Wagner, Moritz Gruetz, Ludwig M. Heindl, Falk Schroedl, Andreas Traweger
Publikováno v:
Cellular Physiology and Biochemistry, Vol 46, Iss 3, Pp 1148-1158 (2018)
Background/Aims: Effective wound-healing generally requires efficient re-vascularization after injury, ensuring sufficient supply with oxygen, nutrients, and various cell populations. While this applies to most tissues, tendons are mostly avascular i
Externí odkaz:
https://doaj.org/article/360739caf6a0487dacaba4da3d5018da
Autor:
Stefanie Korntner, Nadja Kunkel, Christine Lehner, Renate Gehwolf, Andrea Wagner, Peter Augat, Daniel Stephan, Verena Heu, Hans-Christian Bauer, Andreas Traweger, Herbert Tempfer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
Abstract Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone. Although still la
Externí odkaz:
https://doaj.org/article/df41000099164f44a7877e36f5e7efa5
Autor:
Renate Gehwolf, Bettina Schwemberger, Malik Jessen, Stefanie Korntner, Andrea Wagner, Christine Lehner, Nadja Weissenbacher, Herbert Tempfer, Andreas Traweger
Publikováno v:
Cells, Vol 8, Iss 5, p 399 (2019)
Tendinopathy is accompanied by a cascade of inflammatory events promoting tendon degeneration. Among various cytokines, interleukin-1β plays a central role in driving catabolic processes, ultimately resulting in the activation of matrix metalloprote
Externí odkaz:
https://doaj.org/article/72880c8e367042a9a68c0832775f9351
Autor:
Herbert Tempfer, Gabriel Spitzer, Christine Lehner, Andrea Wagner, Renate Gehwolf, Johann Fierlbeck, Nadja Weissenbacher, Malik Jessen, Ludwig M. Heindl, Andreas Traweger
Publikováno v:
The FASEB Journal. 36
Vascular endothelial growth factor (VEGF) signaling is crucial for a large variety of cellular processes, not only related to angiogenesis but also in nonvascular cell types. We have previously shown that controlling angiogenesis by reducing VEGF-A s
Autor:
Dominika Jakubecova, Andreas Traweger, Herbert Tempfer, Renate Gehwolf, Patrick B. Langthaler, Ludwig Aigner, Christine Lehner, Weiß R, Nadja Weissenbacher, Sebastien Couillard-Despres, Bernhard Iglseder, Andrea Wagner, Gabriel Spitzer, Eugen Trinka, Barbara Klein, Bernhard Paulweber
Publikováno v:
EBioMedicine
EBioMedicine, Vol 75, Iss, Pp 103778-(2022)
EBioMedicine, Vol 75, Iss, Pp 103778-(2022)
Summary: Background: Treatment of degenerating tendons still presents a major challenge, since the aetiology of tendinopathies remains poorly understood. Besides mechanical overuse, further known predisposing factors include rheumatoid arthritis, dia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8d33f101002296b7c8214ed5c69f88a
https://doi.org/10.1101/2021.07.02.450910
https://doi.org/10.1101/2021.07.02.450910
Autor:
Moritz Weigl, Fabian Plachel, Christine Lehner, Nadja Weissenbacher, Andreas Traweger, Philipp Moroder, Andrea Wagner, Philipp R. Heuberer, Herbert Tempfer, Renate Gehwolf, Matthias Hackl, Julia K. Frank
Publikováno v:
Journal of Orthopaedic Research
MicroRNAs (miRNAs) have emerged as key regulators orchestrating a wide range of inflammatory and fibrotic diseases. However, the role of miRNAs in degenerative shoulder joint disorders is poorly understood. The aim of this explorative case‐control
Autor:
Stefanie Korntner, Herbert Tempfer, Andreas Traweger, Christine Lehner, Moritz Grütz, Renate Gehwolf, Nadja Kunkel, Andrea Wagner
Publikováno v:
Advanced Drug Delivery Reviews
Angiogenesis, the process of new blood vessel formation from existing blood vessels, is a key aspect of virtually every repair process. During wound healing an extensive, but immature and leaky vascular plexus forms which is subsequently reduced by r
Autor:
Rocky S. Tuan, Claudia Wittner, Sasha Senck, Renate Gehwolf, Qing Jiang, Huajian Teng, Toby Leys, Andreas Traweger, Allan Wang, Qiujian Zheng, Wenjin Yan, Ming H. Zheng, Christine B.F. Thien, Christine Lehner, Tao Wang, Herbert Tempfer, Nadja Weissenbacher, Andrea Wagner, Fabian S. Passini, Ming Ni, Jess G. Snedeker, Zhen Lin, John M. Papadimitriou, Jin Dai
Publikováno v:
Science Translational Medicine. 13
Tendons and tendon interfaces have a very limited regenerative capacity, rendering their injuries clinically challenging to resolve. Tendons sense muscle-mediated load; however, our knowledge on how loading affects tendon structure and functional ada