Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Christine Lange Cannova"'
Autor:
Michelle B. Ayer, Chunshi Li, Anne Gurnett, Michael H. Fisher, Steven L. Colletti, Dennis M. Schmatz, Matthew J. Wyvratt, Paula M. Dulski, Peter T. Meinke, Julie Lim, Tami Crumley, Stefan Galuska, John J. Allocco, Sandra J. Darkin-Rattray, Christine Lange Cannova, Robert W. Myers
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 11:107-111
Apicidin, a natural product recently isolated at Merck, inhibits both mammalian and protozoan histone deacetylases (HDACs). The conversion of apicidin, a nanomolar inhibitor of HDACs, into a series of side-chain analogues that display picomolar enzym
Autor:
Michelle B. Ayer, Chunshi Li, Sandra J. Darkin-Rattray, Paula M. Dulski, Christine Lange Cannova, Dennis M. Schmatz, Matthew J. Wyvratt, Julie Lim, Michael H. Fisher, Anne Gurnett, Tami Crumley, Stefan Galuska, John J. Allocco, Peter T. Meinke, Robert W. Myers, Steven L. Colletti
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(2)
Recently isolated at Merck, apicidin inhibits both mammalian and protozoan histone deacetylases (HDACs). The conversion of apicidin, a nonselective nanomolar inhibitor of HDACs, into a series of picomolar indole-modified and parasite-selective trypto
Autor:
Christine Lange Cannova, Steven L. Colletti, Robert W. Myers, Peter T. Meinke, Dennis M. Schmatz, Sandra J. Darkin-Rattray, Anne Gurnett, John J. Allocco, Tami Crumley, Sheo B. Singh, Jon D. Polishook, Paula M. Dulski, Anne W. Dombrowski, Michael A. Goetz, Maria A. Bednarek
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 93(23)
A novel fungal metabolite, apicidin [cyclo( N - O -methyl- l -tryptophanyl- l -isoleucinyl- d -pipecolinyl- l -2-amino-8-oxodecanoyl)], that exhibits potent, broad spectrum antiprotozoal activity in vitro against Apicomplexan parasites has been ident